Browsing Harvard Medical School by Keyword "chemical screening"
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Deactivation of Akt by a Small Molecule Inhibitor Targeting Pleckstrin Homology Domain and Facilitating Akt Ubiquitination
(Proceedings of the National Academy of Sciences, 2011)The phosphatidylinositol-3,4,5-triphosphate (PIP3) binding function of pleckstrin homology (PH) domain is essential for the activation of oncogenic Akt/PKB kinase. Following the PIP3-mediated activation at the membrane, ... -
A Tool to Utilize Adverse Effect Profiles to Identify Brain-Active Medications for Repurposing
(Oxford University Press, 2015)Background: To shorten the time required to bring new treatments to clinics, recent efforts have focused on repurposing existing Food and Drug Administration (FDA)-approved drugs with established safety data for new ...