Browsing Harvard Medical School by Keyword "cognitive decline"

Now showing items 1-2 of 2

    • Florbetapir F 18 amyloid PET and 36-month cognitive decline:a prospective multicenter study 

      Doraiswamy, P M; Sperling, R A; Johnson, K; Reiman, E M; Wong, T Z; Sabbagh, M N; Sadowsky, C H; Fleisher, A S; Carpenter, A; Joshi, A D; Lu, M; Grundman, M; Mintun, M A; Skovronsky, D M; Pontecorvo, M J; Duara, Ranjan; Sabbagh, Marwan; Lawrence Ahern, Geoffrey; Holub, Richard F; Farmer, Mildred V; Safirstein, Beth Emmie; Alva, Gustavo; Longmire, Crystal F; Jewell, George; Johnson, Keith A; Korn, Ron; Reiman, Eric M; Wendt, Jeanette K; Wong, Dean; Doraiswamy, P Murali; Coleman, R Edward; Devous, Michael; Jennings, Danna; Weiner, Michael W; Murphy, Cynthia A; Kovnat, Karel D; Williamson, Jeff D; Sadowsky, Carl H (Nature Publishing Group, 2014)
      This study was designed to evaluate whether subjects with amyloid beta (Aβ) pathology, detected using florbetapir positron emission tomorgraphy (PET), demonstrated greater cognitive decline than subjects without Aβ pathology. ...

    • Modifying Effects of the HFE Polymorphisms on the Association Between Lead Burden and Cognitive Decline 

      Wang, Florence T.; Hu, Howard; Schwartz, Joel David; Weuve, Jennifer Lynn; Spiro, Avron S.; Sparrow, David; Nie, Huiling; Silverman, Edwin Kepner; Weiss, Scott Tillman; Wright, Robert O. (National Institute of Environmental Health Sciences, 2007)
      Background: As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship. Objective: ...