Browsing Harvard Medical School by Keyword "colon cancer"

Now showing items 1-4 of 4

    • Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors 

      Ducker, Gregory S.; Atreya, Chloe E.; Simko, Jeffry P.; Hom, Yun K.; Matli, Mary R.; Benes, Cyril H.; Hann, Byron; Nakakura, Eric K.; Bergsland, Emily K.; Donner, David B.; Settleman, Jeffrey; Shokat, Kevan M.; Warren, Robert S. (2014)
      The mammalian target of rapamycin (mTOR) regulates cell growth by integrating nutrient and growth factor signaling and is strongly implicated in cancer. But mTOR is not an oncogene, and which tumors will be resistant or ...

    • MUC1-C ACTIVATES THE TAK1 INFLAMMATORY PATHWAY IN COLON CANCER 

      Takahashi, Hidekazu; Jin, Caining; Rajabi, Hasan; Pitroda, Sean; Alam, Maroof; Ahmad, Rehan; Raina, Deepak; Hasegawa, Masanori; Suzuki, Yozo; Tagde, Ashujit; Bronson, Roderick T.; Weichselbaum, Ralph; Kufe, Donald (2015)
      The mucin 1 (MUC1) oncoprotein has been linked to the inflammatory response by promoting cytokine-mediated activation of the NF-κB pathway. The TGF-β-activated kinase 1 (TAK1) is an essential effector of proinflammatory ...

    • Response of irradiated and bystander cells to charged particles in two-dimensional and three-dimensional colon models 

      Li, Chunjie; Kawamura, Hidemasa; Khaled, Saman; Held, Kathryn D. (Oxford University Press, 2014)
      The radiation-induced bystander effect, wherein unirradiated cells near to or sharing medium with irradiated cells express biological responses, most often has been studied in two-dimensional monolayer cultures, although ...

    • SOX2 Expression Correlates with Lymph-node Metastases and Distant Spread in Right-sided Colon Cancer 

      Neumann, Jens; Bahr, Fiorina; Horst, David Nicolai; Kriegl, Lydia; Engel, Jutta; Luque, Raquel Mejias; Gerhard, Markus; Kirchner, Thomas; Jung, Andreas (BioMed Central, 2011)
      Background: The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). Furthermore, ...