Browsing Harvard Medical School by Keyword "colorectal cancer"
Now showing items 1-17 of 17
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Association of local capacity for endoscopy with individual use of colorectal cancer screening and stage at diagnosis
(Wiley-Blackwell, 2010)BACKGROUND: Limited capacity for endoscopy in areas in which African Americans and Hispanics live may be a reason for persistent disparities in colorectal cancer (CRC) screening and stage at diagnosis. METHODS: The authors ... -
CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk
(Nature Publishing Group, 2016)Background: Menopausal hormone therapy (MHT) use has been consistently associated with a decreased risk of colorectal cancer (CRC) in women. Our aim was to use a genome-wide gene–environment interaction analysis to identify ... -
Diagnostic reproducibility of tumour budding in colorectal cancer: a multicentre, multinational study using virtual microscopy
(Wiley-Blackwell, 2012)Aims: Despite the established prognostic relevance of tumour budding in colorectal cancer, the reproducibility of the methods reported for its assessment has not yet been determined, limiting its use and reporting in ... -
Effective MAPK Inhibition is critical for therapeutic responses in colorectal cancer with BRAF mutations
(Taylor & Francis, 2016)ABSTRACT RAF inhibitor monotherapy is ineffective in BRAF-mutant colorectal cancer (CRC) but RAF inhibitor combinations have demonstrated improved efficacy, likely through superior suppression of MAPK signaling. The first ... -
An EGFR Targeted PET Imaging Probe for the Detection of Colonic Adenocarcinomas in the Setting of Colitis
(Ivyspring International Publisher, 2014)Colorectal cancer is a serious complication associated with inflammatory bowel disease, often indistinguishable by screening with conventional FDG PET probes. We have developed an alternative EGFR-targeted PET imaging probe ... -
Habitual intake of flavonoid subclasses and risk of colorectal cancer in 2 large prospective cohorts12
(American Society for Nutrition, 2016)Background: Flavonoids inhibit the growth of colon cancer cells in vitro. In a secondary analysis of a randomized controlled trial, the Polyp Prevention Trial, a higher intake of one subclass, flavonols, was statistically ... -
Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis
(Impact Journals LLC, 2015)The DNA glycosylase gene MBD4 safeguards genomic stability at CpG sites and is frequently mutated at coding poly-A tracks in mismatch repair (MMR)-defective colorectal tumors (CRC). Mbd4 biallelic inactivation in mice ... -
IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer
(Blackwell Publishing Ltd, 2013)Copy number alterations are frequently found in colorectal cancer (CRC), and recurrent gains or losses are likely to correspond to regions harbouring genes that promote or impede carcinogenesis respectively. Gain of ... -
Is DNA methylation of tumour suppressor genes epigenetic?
(eLife Sciences Publications, Ltd, 2014)In colorectal cancer cells, a non-epigenetic transcriptional pathway that is mediated by an oncogene maintains DNA methylation of tumour suppressor genes -
Lipidome in colorectal cancer
(Impact Journals LLC, 2016)Colorectal cancer (CRC) is the second leading cause of cancer-related deaths. Understanding its pathophysiology is essential for developing efficient strategies to treat this disease. Lipidome, the sum of total lipids, ... -
Magnesium intake, plasma C-peptide, and colorectal cancer incidence in US women: a 28-year follow-up study
(Nature Publishing Group, 2012)Background: Laboratory studies suggest a possible role of magnesium intake in colorectal carcinogenesis but epidemiological evidence is inconclusive. Method: We tested magnesium–colorectal cancer hypothesis in the Nurses' ... -
Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer
(Nature Publishing Group, 2016)Background: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a ... -
Neonatal Fc receptors for IgG drive CD8+ T cell-mediated anti-cancer immunosurveillance at tolerogenic mucosal sites
(Landes Bioscience, 2014)Mucosal boundaries, which are immunologically tolerogenic, and is further enhanced by undergo malignant transformation at high rates. We have identified the expression of neonatal Fc receptor for IgG (FcRn) by dendritic ... -
Nut consumption and risk of colorectal cancer in women
(Nature Publishing Group, 2015)Background/Objectives: Increasing nut consumption has been associated with reduced risk of obesity and type II diabetes, which are risk factors for colorectal cancer. However, the association between nut consumption and ... -
Retrospective Evaluation of Elastic Stain in the Assessment of Serosal Invasion of pT3N0 Colorectal Cancers
(Ovid Technologies (Wolters Kluwer Health), 2013)Peritoneal involvement is an important adverse prognostic factor in colorectal cancer (CRC) and determines a shift in the pathologic tumor node metastasis stage. Because peritoneal involvement is difficult to identify, use ... -
Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours
(John Wiley & Sons, Ltd, 2013)The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This ... -
Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer
(Frontiers Media S.A., 2014)Liver metastases from colorectal cancer (CRC) result in substantial morbidity and mortality. The primary treatment is systemic chemotherapy, and in selected patients, surgical resection; however, for patients who are not ...