Browsing Harvard Medical School by Keyword "cytoskeleton"

Now showing items 1-9 of 9

    • Bacterial and Host Determinants of MAL Activation upon EPEC Infection: The Roles of Tir, ABRA, and FLRT3 

      Heath, Robert John William; Leong, John M.; Visegrády, Balázs; Machesky, Laura M.; Xavier, Ramnik (Public Library of Science, 2011)
      Infection of host cells by pathogenic microbes triggers signal transduction pathways leading to a multitude of host cell responses including actin cytoskeletal re-arrangements and transcriptional programs. The diarrheagenic ...

    • DIAPH3 Governs the Cellular Transition to the Amoeboid Tumour Phenotype 

      Hager, Martin H; Morley, Samantha; Bielenberg, Diane R; Gao, Sizhen; Morello, Matteo; Holcomb, Ilona N; Liu, Wennuan; Mouneimne, Ghassan; Demichelis, Francesca; Kim, Jayoung; Solomon, Keith R; Adam, Rosalyn M; Isaacs, William B; Higgs, Henry N; Vessella, Robert L; Di Vizio, Dolores; Freeman, Michael R (WILEY-VCH Verlag, 2012)
      Therapies for most malignancies are generally ineffective once metastasis occurs. While tumour cells migrate through tissues using diverse strategies, the signalling networks controlling such behaviours in human tumours ...

    • Directional Spread of Alphaherpesviruses in the Nervous System 

      Kramer, Tal; Enquist, Lynn W. (MDPI, 2013)
      Alphaherpesviruses are pathogens that invade the nervous systems of their mammalian hosts. Directional spread of infection in the nervous system is a key component of the viral lifecycle and is critical for the onset of ...

    • GEF-H1 Mediated Control of NOD1 Dependent NF-κB Activation by Shigella Effectors 

      Fukazawa, Atsuko; Alonso, Carmen; Kurachi, Kiyotaka; Gupta, Sonal; Philpott, Dana J.; Lesser, Cammie; McCormick, Beth A.; Reinecker, Hans-Christian (Public Library of Science, 2008)
      Shigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune ...

    • Identification of Novel Pro-Migratory, Cancer-Associated Genes Using Quantitative, Microscopy-Based Screening 

      Naffar-Abu-Amara, Suha; Shay, Tal; Galun, Meirav; Cohen, Naomi; Isakoff, Steven Jay; Kam, Zvi; Geiger, Benjamin (Public Library of Science, 2008)
      Background: Cell migration is a highly complex process, regulated by multiple genes, signaling pathways and external stimuli. To discover genes or pharmacological agents that can modulate the migratory activity of cells, ...

    • Platelet Granule Exocytosis: A Comparison with Chromaffin Cells 

      Fitch-Tewfik, Jennifer L.; Flaumenhaft, Robert (Frontiers Media S.A., 2013)
      The rapid secretion of bioactive amines from chromaffin cells constitutes an important component of the fight or flight response of mammals to stress. Platelets respond to stresses within the vasculature by rapidly secreting ...

    • Proteomic analysis of metabolic, cytoskeletal and stress response proteins in human heart failure 

      Li, Weiming; Rong, Rong; Zhao, Sheng; Zhu, Xiaoming; Zhang, Ke; Xiong, Xin; Yu, Xueqing; Cui, Qinghua; Li, Shuqiang; Chen, Li; Cai, Jun; Du, Jie (Blackwell Publishing Ltd, 2011)
      Abstract Human heart failure is a complex syndrome and a primary cause of morbidity and mortality in the world. However, the molecular pathways involved in the remodelling process are poorly understood. In this study, we ...

    • Pyrin Modulates the Intracellular Distribution of PSTPIP1 

      Waite, Andrea L.; Schaner, Philip; Richards, Neil; Balci-Peynircioglu, Banu; Masters, Seth L.; Brydges, Susannah D.; Hong, Arthur; Yilmaz, Engin; Kastner, Daniel L.; Gumucio, Deborah L.; May, Robin Charles; Fox, Michelle; Reinherz, Ellis Leonard (Public Library of Science, 2009)
      PSTPIP1 is a cytoskeleton-associated adaptor protein that links PEST-type phosphatases to their substrates. Mutations in PSTPIP1 cause PAPA syndrome (Pyogenic sterile Arthritis, Pyoderma gangrenosum, and Acne), an ...

    • Tubular Bridges for Bronchial Epithelial Cell Migration and Communication 

      Zani, Brett G.; Indolfi, Laura; Edelman, Elazer Reuven (Public Library of Science, 2010)
      Background: Biological processes from embryogenesis to tumorigenesis rely on the coordinated coalescence of cells and synchronized cell-to-cell communication. Intercellular signaling enables cell masses to communicate ...