Browsing Harvard Medical School by Keyword "degradation"

Now showing items 1-4 of 4

    • Negative regulation of DAB2IP by Akt and SCFFbw7 pathways 

      Dai, Xiangping; North, Brian J.; Inuzuka, Hiroyuki (Impact Journals LLC, 2014)
      Deletion of ovarian carcinoma 2/disabled homolog 2 (DOC-2/DAB2) interacting protein (DAB2IP), is a tumor suppressor that serves as a scaffold protein involved in coordinately regulating cell proliferation, survival and ...

    • SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination 

      Wu, Xiaomian; Fukushima, Hidefumi; North, Brian J.; Nagaoka, Yoshiyuki; Nagashima, Katsuyuki; Deng, Feng; Okabe, Koji; Inuzuka, Hiroyuki; Wei, Wenyi (Impact Journals LLC, 2014)
      CYLD negatively regulates the NF-κB signaling pathway and osteoclast differentiation largely through antagonizing TNF receptor-associated factor (TRAF)-mediated K63-linkage polyubiquitination in osteoclast precursor cells. ...

    • SCFβ-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway 

      Liu, Jia; Wan, Lixin; Liu, Pengda; Inuzuka, Hiroyuki; Liu, Jiankang; Wang, Zhiwei; Wei, Wenyi (Impact Journals LLC, 2014)
      The HECT domain-containing ubiquitin E3 ligase NEDD4 is widely expressed in mammalian tissues and plays a crucial role in governing a wide spectrum of cellular processes including cell growth, tissue development and ...

    • Smurf1 regulation of DAB2IP controls cell proliferation and migration 

      Li, Xiaoning; Dai, Xiangpeng; Wan, Lixin; Inuzuka, Hiroyuki; Sun, Liankun; North, Brian J. (Impact Journals LLC, 2016)
      Tumor cell proliferation, survival and migration are regulated by the deletion of ovarian carcinoma 2/disabled homolog 2 (DOC-2/DAB2) interacting protein (DAB2IP), a tumor suppressor that serves as a scaffold protein for ...