Browsing Harvard Medical School by Keyword "dementia"
Now showing items 1-12 of 12
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The Confusion Assessment Method: A Systematic Review of Current Usage
(Wiley-Blackwell, 2008) -
Delirium Severity Post-Surgery and its Relationship with Long-Term Cognitive Decline in a Cohort of Patients without Dementia
(IOS Press, 2017)Background: Delirium has been associated with more rapid cognitive decline. However, it is unknown whether increased delirium severity is associated with a higher rate of long-term cognitive decline. Objective: To evaluate ... -
Dementia and Race: Are There Differences Between African Americans and Caucasians?
(Wiley-Blackwell, 2001)This study provides an overview of racial differences in etiology and prevalence of dementia. Preliminary findings indicate that the clinical and molecular etiologies of dementia differ between races. African Americans ... -
Diagnosing Delirium in Older Hospitalized Adults with Dementia: Adapting the Confusion Assessment Method to International Classification of Diseases, Tenth Revision, Diagnostic Criteria
(Wiley-Blackwell, 2012)OBJECTIVES: To compare performance characteristics of the Confusion Assessment Method (CAM) algorithm for screening and delirium diagnosis with criteria for delirium from the International Classification of Diseases, Tenth ... -
FASTKD2 is associated with memory and hippocampal structure in older adults
(2014)Memory impairment is the cardinal early feature of Alzheimer's disease (AD), a highly prevalent disorder whose causes remain only partially understood. To identify novel genetic predictors, we used an integrative genomics ... -
Multicomponent Targeted Intervention to Prevent Delirium in Hospitalized Older Patients
(Ovid Technologies (Wolters Kluwer Health), 2001)Introduction. Delirium, or acute confusional state, is a common and serious occurrence among hospitalized older persons. Current estimates suggest that delirium complicates hospital stays for more than 2.3 million older ... -
Reducing Amyloid Plaque Burden via Ex Vivo Gene Delivery of an Aβ-Degrading Protease: A Novel Therapeutic Approach to Alzheimer Disease
(Public Library of Science, 2007)Background: Understanding the mechanisms of amyloid-β protein (Aβ) production and clearance in the brain has been essential to elucidating the etiology of Alzheimer disease (AD). Chronically decreasing brain Aβ levels is ... -
Short-Term Outcomes in Older Intensive Care Unit Patients With Dementia*
(Ovid Technologies (Wolters Kluwer Health), 2005)Objective: To determine the impact of dementia on the outcomes of intensive care unit (ICU) care and use of ICU interventions among older patients. Design: Prospective observational cohort study. Setting: Urban university ... -
Shorter Telomeres May Mark Early Risk of Dementia: Preliminary Analysis of 62 Participants from the Nurses' Health Study
(Public Library of Science, 2008)Background: Dementia takes decades to develop, and effective prevention will likely require early intervention. Thus, it is critical to identify biomarkers of preclinical disease, allowing targeting of high-risk subjects ... -
Temporal Lobe Cortical Electrical Stimulation during the Encoding and Retrieval Phase Reduces False Memories
(Public Library of Science, 2009)A recent study found that false memories were reduced by 36% when low frequency repetitive transcranial magnetic stimulation (rTMS) was applied to the left anterior temporal lobe after the encoding (study) phase. Here we ... -
Tools to Detect Delirium Superimposed on Dementia: A Systematic Review
(Wiley-Blackwell, 2012) -
A Yeast Model of FUS/TLS-Dependent Cytotoxicity
(Public Library of Science, 2011)FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus, the pathogenic mutant ...