Browsing Harvard Medical School by Keyword "diagnosis"

Now showing items 1-17 of 17

    • Alpha-synuclein in cutaneous small nerve fibers 

      Siepmann, Timo; Illigens, Ben Min-Woo; Barlinn, Kristian (Dove Medical Press, 2016)
      Despite progression in the development of pharmacological therapy, treatment of alpha synucleinopathies, such as Parkinson’s disease (PD) and some atypical parkinsonism syndromes, is still challenging. To date, our knowledge ...

    • Automated grading system for evaluation of ocular redness associated with dry eye 

      Rodriguez, John D; Johnston, Patrick R; Ousler, George W; Smith, Lisa M; Abelson, Mark B (Dove Medical Press, 2013)
      Background: We have observed that dry eye redness is characterized by a prominence of fine horizontal conjunctival vessels in the exposed ocular surface of the interpalpebral fissure, and have incorporated this feature ...

    • Changes in Medical Therapy and Lifestyle After Anatomical or Functional Testing for Coronary Artery Disease 

      Ladapo, Joseph A.; Hoffmann, Udo; Lee, Kerry L.; Coles, Adrian; Huang, Megan; Mark, Daniel B.; Dolor, Rowena J.; Pelberg, Robert A.; Budoff, Matthew; Sigurdsson, Gardar; Severance, Harry W.; Douglas, Pamela S. (John Wiley and Sons Inc., 2016)
      Background: Diagnostic testing in the care of patients newly presenting with symptoms suggestive of coronary artery disease may influence risk factor management, independent of test type or test results. However, little ...

    • Clinical application of brain imaging for the diagnosis of mood disorders: the current state of play 

      Savitz, J B; Rauch, Scott Laurence; Drevets, W C (Nature Publishing Group, 2013)
      In response to queries about whether brain imaging technology has reached the point where it is useful for making a clinical diagnosis and for helping to guide treatment selection, the American Psychiatric Association (APA) ...

    • Clinical Pertinence Metric Enables Hypothesis-Independent Genome-Phenome Analysis for Neurologic Diagnosis 

      Segal, Michael M.; Abdellateef, Mostafa; El-Hattab, Ayman W.; Hilbush, Brian S.; De La Vega, Francisco M.; Tromp, Gerard; Williams, Marc S.; Betensky, Rebecca A.; Gleeson, Joseph (SAGE Publications, 2014)
      We describe an “integrated genome-phenome analysis” that combines both genomic sequence data and clinical information for genomic diagnosis. It is novel in that it uses robust diagnostic decision support and combines the ...

    • Collaborating to Move Research Forward: Proceedings of the 10th Annual Bladder Cancer Think Tank 

      Kamat, Ashish M.; Agarwal, Piyush; Bivalacqua, Trinity; Chisolm, Stephanie; Daneshmand, Sia; Doroshow, James H.; Efstathiou, Jason A.; Galsky, Matthew; Iyer, Gopa; Kassouf, Wassim; Shah, Jay; Taylor, John; Williams, Stephen B.; Quale, Diane Zipursky; Rosenberg, Jonathan E. (IOS Press, 2016)
      The 10th Annual Bladder Cancer Think Tank was hosted by the Bladder Cancer Advocacy Network and brought together a multidisciplinary group of clinicians, researchers, representatives and Industry to advance bladder cancer ...

    • Comorbidity Between Attention Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder Across the Lifespan: A Systematic and Critical Review 

      Abramovitch, Amitai; Dar, Reuven; Mittelman, Andrew; Wilhelm, Sabine (Lippincott Williams & Wilkins, 2015)
      Abstract The concept of comorbidity between attention deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) has been discussed for two decades. No review, however, has examined this question in light ...

    • Degos disease – malignant atrophic papulosis or cutaneointestinal lethal syndrome: rarity of the disease 

      Pirolla, Eduardo; Fregni, Felipe; Miura, Irene K; Misiara, Antonio Carlos; Almeida, Fernando; Zanoni, Esdras (Dove Medical Press, 2015)
      Background: Degos disease is a very rare syndrome with a rare type of multisystem vasculopathy of unknown cause that affects the skin, gastrointestinal tract, and central nervous system. Other organs such as the kidneys, ...

    • Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: Proposed Modification of the Task Force Criteria 

      Marcus, F. I.; McKenna, William; Sherrill, D.; Basso, C.; Bauce, B.; Bluemke, D. A.; Calkins, H.; Corrado, D.; Cox, M. G. P. J.; Daubert, J. P.; Fontaine, G.; Gear, K.; Hauer, R.; Nava, A.; Picard, Michael Howard; Protonotarios, N.; Saffitz, Jeffrey E; Sanborn, Danita M. Yoerger; Steinberg, J. S.; Tandri, H.; Thiene, G.; Towbin, J. A.; Tsatsopoulou, A.; Wichter, T.; Zareba, W. (Ovid Technologies (Wolters Kluwer Health), 2010)
      Background: In 1994, an International Task Force proposed criteria for the clinical diagnosis of ARVC/D which facilitated recognition and interpretation of the frequently non-specific clinical features of ARVC/D. This ...

    • Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts’ Criteria 

      Catassi, Carlo; Elli, Luca; Bonaz, Bruno; Bouma, Gerd; Carroccio, Antonio; Castillejo, Gemma; Cellier, Christophe; Cristofori, Fernanda; de Magistris, Laura; Dolinsek, Jernej; Dieterich, Walburga; Francavilla, Ruggiero; Hadjivassiliou, Marios; Holtmeier, Wolfgang; Körner, Ute; Leffler, Dan A.; Lundin, Knut E. A.; Mazzarella, Giuseppe; Mulder, Chris J.; Pellegrini, Nicoletta; Rostami, Kamran; Sanders, David; Skodje, Gry Irene; Schuppan, Detlef; Ullrich, Reiner; Volta, Umberto; Williams, Marianne; Zevallos, Victor F.; Zopf, Yurdagül; Fasano, Alessio (MDPI, 2015)
      Non-Celiac Gluten Sensitivity (NCGS) is a syndrome characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected by either celiac disease ...

    • Early Diagnosis of Peripheral Nervous System Involvement in Fabry Disease and Treatment of Neuropathic Pain: The Report of an Expert Panel 

      Burlina, Allesandro P; Sims, Katherine Bustin; Politei, Juan M; Bennett, Gary J; Baron, Ralf; Sommer, Claudia; Moller, Anette Torvin; Hilz, Max J (BioMed Central, 2011)
      Background: Fabry disease is an inherited metabolic disorder characterized by progressive lysosomal accumulation of lipids in a variety of cell types, including neural cells. Small, unmyelinated nerve fibers are particularly ...

    • Imported Fasciola hepatica Infection in the United States and Treatment with Triclabendazole 

      Graham, Camilla Suzanne; Brodie, Sharon B.; Weller, Peter Fahey (Oxford University Press (OUP), 2001)
      Infection with Fasciola hepatica, a liver trematode, is not frequently reported in the United States. We describe 2 patients, both originally from Cape Verde, who illustrate the spectrum of clinical presentations of F. ...

    • The limitations of qPCR telomere length measurement in diagnosing dyskeratosis congenita 

      Gadalla, Shahinaz M.; Khincha, Payal P.; Katki, Hormuzd A.; Giri, Neelam; Wong, Jason Y. Y.; Spellman, Stephen; Yanovski, Jack A.; Han, Joan C.; De Vivo, Immaculata; Alter, Blanche P.; Savage, Sharon A. (John Wiley and Sons Inc., 2016)
      Abstract Background: Telomere length <1st percentile‐for‐age in leukocyte subsets by flow cytometry with fluorescence in situ hybridization (flow FISH) is highly sensitive and specific in diagnosing patients with dyskeratosis ...

    • The new paradigm of hepatitis C therapy: integration of oral therapies into best practices 

      Afdhal, N H; Zeuzem, S; Schooley, R T; Thomas, D L; Ward, J W; Litwin, A H; Razavi, H; Castera, L; Poynard, T; Muir, A; Mehta, S H; Dee, L; Graham, C; Church, D R; Talal, A H; Sulkowski, M S; Jacobson, I M for the New Paradigm of HCV Therapy Meeting Participants (John Wiley & Sons, 2013)
      SUMMARY. Emerging data indicate that all-oral antiviral treatments for chronic hepatitis C virus (HCV) will become a reality in the near future. In replacing interferon-based therapies, all-oral regimens are expected to ...

    • Primary Immune Deficiencies – Principles of Care 

      Chapel, Helen; Prevot, Johan; Gaspar, Hubert Bobby; Español, Teresa; Bonilla, Francisco A.; Solis, Leire; Drabwell, Josina (Frontiers Media S.A., 2014)
      Primary immune deficiencies (PIDs) are a growing group of over 230 different disorders caused by ineffective, absent or an increasing number of gain of function mutations in immune components, mainly cells and proteins. ...

    • Recognition of Depressive Symptoms by Physicians 

      Henriques, Sergio Gonçalves; Fráguas, Renério; Iosifescu, Dan Vlad; Menezes, Paulo Rossi; de Lucia, Mara Cristina Souza; Gattaz, Wagner Farid; Martins, Milton Arruda (Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, 2009)
      OBJECTIVE: To investigate the recognition of depressive symptoms of major depressive disorder (MDD) by general practitioners. INTRODUCTION: MDD is underdiagnosed in medical settings, possibly because of difficulties in the ...

    • SIOP‐PODC adapted risk stratification and treatment guidelines: Recommendations for neuroblastoma in low‐ and middle‐income settings 

      Parikh, Nehal S.; Howard, Scott C.; Chantada, Guillermo; Israels, Trijn; Khattab, Mohammed; Alcasabas, Patricia; Lam, Catherine G.; Faulkner, Lawrence; Park, Julie R.; London, Wendy B.; Matthay, Katherine K. (John Wiley and Sons Inc., 2015)
      Neuroblastoma is the most common extracranial solid tumor in childhood in high‐income countries (HIC), where consistent treatment approaches based on clinical and tumor biological risk stratification have steadily improved ...