Browsing Harvard Medical School by Keyword "macromolecular structure analysis"

Now showing items 1-4 of 4

    • The Hexamer Structure of the Rift Valley Fever Virus Nucleoprotein Suggests a Mechanism for its Assembly into Ribonucleoprotein Complexes 

      Danek, Eric I.; Luo, Dahai; Wong, Yeehwa; Coutard, Bruno; Lantez, Violaine; Canard, Bruno; Lescar, Julien; Ferron, François; Charrel, Rémi; Li, Zongli; Walz, Thomas (Public Library of Science, 2011)
      Rift Valley fever virus (RVFV), a Phlebovirus with a genome consisting of three single-stranded RNA segments, is spread by infected mosquitoes and causes large viral outbreaks in Africa. RVFV encodes a nucleoprotein (N) ...

    • Kinetics of Proton Transport into Influenza Virions by the Viral M2 Channel 

      Ivanovic, Tijana; Rozendaal, Rutger; Floyd, Daniel Lee; Popovic, Milos; van Oijen, Antoine M.; Harrison, Stephen C. (Public Library of Science, 2012)
      M2 protein of influenza A viruses is a tetrameric transmembrane proton channel, which has essential functions both early and late in the virus infectious cycle. Previous studies of proton transport by M2 have been limited ...

    • A Stevedore's Protein Knot 

      Bölinger, Daniel; Sułkowska, Joanna I.; Hsu, Hsiao-Ping; Mirny, Leonid Alex; Kardar, Mehran; Onuchic, José N.; Virnau, Peter (Public Library of Science, 2010)
      Protein knots, mostly regarded as intriguing oddities, are gradually being recognized as significant structural motifs. Seven distinctly knotted folds have already been identified. It is by and large unclear how these ...

    • Three-Dimensional Genome Architecture Influences Partner Selection for Chromosomal Translocations in Human Disease 

      Engreitz, Jesse Michael; Agarwala, Vineeta; Mirny, Leonid Alex (Public Library of Science, 2012)
      Chromosomal translocations are frequent features of cancer genomes that contribute to disease progression. These rearrangements result from formation and illegitimate repair of DNA double-strand breaks (DSBs), a process ...