Browsing Harvard Medical School by Keyword "vaccine"
Now showing items 1-8 of 8
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Efficacy of Antibody to PNAG Against Keratitis Caused by Fungal Pathogens
(The Association for Research in Vision and Ophthalmology, 2016)Purpose Developing immunotherapies for fungal eye infections is a high priority. We analyzed fungal pathogens for expression of the surface polysaccharide, poly-N-acetyl glucosamine (PNAG), and used a mouse model of ocular ... -
Heat Shock Proteins: Conditional Mediators of Inflammation in Tumor Immunity
(Frontiers Research Foundation, 2012)Heat shock protein (HSP)-based anticancer vaccines have undergone successful preclinical testing and are now entering clinical trial. Questions still remain, however regarding the immunological properties of HSPs. It is ... -
LabKey Server NAb: A Tool for Analyzing, Visualizing and Sharing Results from Neutralizing Antibody Assays
(BioMed Central, 2011)Background: Multiple types of assays allow sensitive detection of virus-specific neutralizing antibodies. For example, the extent of antibody neutralization of HIV-1, SIV and SHIV can be measured in the TZM-bl cell line ... -
A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity
(Frontiers Media S.A., 2016)Background: Group B Neisseria meningitidis, an endotoxin-producing Gram-negative bacterium, causes the highest incidence of group B meningococcus (MenB) disease in the first year of life. The Bexsero vaccine is indicated ... -
Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators
(Taylor & Francis, 2015)Oxygenation of tumors weakens the tumor-protecting immunosuppressive signaling by A2A adenosine receptors in hypoxic and extracellular adenosine-rich microenvironments. This, in turn, unleashes the otherwise inhibited ... -
Personal neoantigen cancer vaccines: The momentum builds
(Landes Bioscience, 2014)Neoantigen-based cancer vaccines designed to target the unique immunogenic mutations arising in each patient’s tumor are breathing new life into a struggling approach. Data continue to demonstrate the importance of neoantigens ... -
Specific temperature-induced perturbations of secondary mRNA structures are associated with the cold-adapted temperature-sensitive phenotype of influenza A virus
(Landes Bioscience, 2012)For decades, cold-adapted, temperature-sensitive (ca/ts) strains of influenza A virus have been used as live attenuated vaccines. Due to their great public health importance it is crucial to understand the molecular ...