Browsing HMS Scholarly Articles by Keyword "fMRI"
Now showing items 21-40 of 55
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Dense, shape‐optimized posterior 32‐channel coil for submillimeter functional imaging of visual cortex at 3T
(John Wiley and Sons Inc., 2015)Purpose Functional neuroimaging of small cortical patches such as columns is essential for testing computational models of vision, but imaging from cortical columns at conventional 3T fields is exceedingly difficult. By ... -
Disrupted functional connectivity of the periaqueductal gray in chronic low back pain
(Elsevier, 2014)Chronic low back pain is a common neurological disorder. The periaqueductal gray (PAG) plays a key role in the descending modulation of pain. In this study, we investigated brain resting state PAG functional connectivity ... -
Do the neural correlates of acupuncture and placebo effects differ?
(Ovid Technologies (Wolters Kluwer Health), 2007)The neurophysiological basis of therapeutic acupuncture is not well understood but is likely to consist of both specific and non-specific (e.g. placebo) effects. Data from animal studies suggest that endogenous anti-nociceptive ... -
The Effects of Methylphenidate on Cognitive Control in Active Methamphetamine Dependence Using Functional Magnetic Resonance Imaging
(Frontiers Media S.A., 2014)Methamphetamine (MA) dependence is associated with cognitive deficits. Methylphenidate (MPH) has been shown to improve inhibitory control in healthy and cocaine-dependent subjects. This study aimed to understand the ... -
Emotional contagion for pain is intact in autism spectrum disorders
(Nature Publishing Group, 2014)Perceiving others in pain generally leads to empathic concern, consisting of both emotional and cognitive processes. Empathy deficits have been considered as an element contributing to social difficulties in individuals ... -
Factors in sensory processing of prosody in schizotypal personality disorder: An fMRI experiment
(Elsevier BV, 2010)Introduction—Persons diagnosed with schizophrenia demonstrate deficits in prosody recognition. To examine prosody along the schizophrenia spectrum, antipsychotic-naïve schizotypal personality disorder (SPD) subjects and ... -
Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology
(Oxford University Press, 2012)Advanced aging is associated with reduced attentional control and less flexible information processing. Here, the origins of these cognitive effects were explored using a functional magnetic resonance imaging task that ... -
Functional and diffusion tensor magnetic resonance imaging of the sheep brain
(BioMed Central, 2015)Background: An ovine model can cast great insight in translational neuroscientific research due to its large brain volume and distinct regional neuroanatomical structures. The present study examined the applicability of ... -
Functional and structural brain correlates of risk for major depression in children with familial depression
(Elsevier, 2015)Despite growing evidence for atypical amygdala function and structure in major depression, it remains uncertain as to whether these brain differences reflect the clinical state of depression or neurobiological traits that ... -
Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia
(Proceedings of the National Academy of Sciences, 2009)We examined the status of the neural network mediating the default mode of brain function, which typically exhibits greater activation during rest than during task, in patients in the early phase of schizophrenia and in ... -
Imaging Studies in Focal Dystonias: A Systems Level Approach to Studying a Systems Level Disorder
(Bentham Science Publishers, 2013)Focal dystonias are dystonias that affect one part of the body, and are sometimes task-specific. Brain imaging and transcranial magnetic stimulation techniques have been valuable in defining the pathophysiology of dystonias ... -
Importance of Reward and Prefrontal Circuitry in Hunger and Satiety: Prader-Willi Syndrome vs. Simple Obesity
(2011)Background: The majority of research on obesity has focused primarily on clinical features (eating behavior, adiposity measures), or peripheral appetite-regulatory peptides (leptin, ghrelin). However, recent functional ... -
An Increase in Tobacco Craving Is Associated with Enhanced Medial Prefrontal Cortex Network Coupling
(Public Library of Science, 2014)Craving is a key aspect of drug dependence that is thought to motivate continued drug use. Numerous brain regions have been associated with craving, suggesting that craving is mediated by a distributed brain network. Whether ... -
Increased Functional Activation of Limbic Brain Regions during Negative Emotional Processing in Migraine
(Frontiers Media S.A., 2016)Pain is both an unpleasant sensory and emotional experience. This is highly relevant in migraine where cortical hyperexcitability in response to sensory stimuli (including pain, light, and sound) has been extensively ... -
Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosa
(Frontiers Media S.A., 2014)The etiology of anorexia nervosa (AN) is poorly understood. Results from functional brain imaging studies investigating the neural profile of AN using cognitive and emotional task paradigms are difficult to reconcile. ... -
Increased Visual Stimulation Systematically Decreases Activity in Lateral Intermediate Cortex
(Oxford University Press, 2014)Previous studies have attributed multiple diverse roles to the posterior superior temporal cortex (STC), both visually driven and cognitive, including part of the default mode network (DMN). Here, we demonstrate a unifying ... -
The Influence of Rest Period Instructions on the Default Mode Network
(Frontiers Media SA, 2010)The default mode network (DMN) refers to regional brain activity that is greater during rest periods than during attention-demanding tasks; many studies have reported DMN alterations in patient populations. It has also ... -
Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity
(Wiley-Blackwell, 2010)OBJECTIVE Fibromyalgia (FM) is considered to be the prototypical central chronic pain syndrome and is associated with widespread pain that fluctuates spontaneously. Multiple studies have demonstrated altered brain ... -
Multi-Scale Glycemic Variability: A Link to Gray Matter Atrophy and Cognitive Decline in Type 2 Diabetes
(Public Library of Science, 2014)Objective: Type 2 diabetes mellitus (DM) accelerates brain aging and cognitive decline. Complex interactions between hyperglycemia, glycemic variability and brain aging remain unresolved. This study investigated the ... -
Multimodal analysis of cortical chemoarchitecture and macroscale fMRI resting‐state functional connectivity
(John Wiley and Sons Inc., 2016)Abstract The cerebral cortex is well known to display a large variation in excitatory and inhibitory chemoarchitecture, but the effect of this variation on global scale functional neural communication and synchronization ...