Browsing HMS Scholarly Articles by Keyword "infectious diseases"

Now showing items 21-40 of 136

    • Comparative Proteomic Analysis of the PhoP Regulon in Salmonella enterica Serovar Typhi Versus Typhimurium 

      Lebrun, Lauren M.; Sheikh, Alaullah; Logvinenko, Tanya; Tarique, Abdullah; Krastins, Bryan; Qadri, Firdausi; Charles, Richelle Candice; Harris, Jason B.; Chase, Michael Richard; Larocque, Regina Celes; Rollins, Sean McKenzie; Hohmann, Elizabeth Louise; Rosenberg, Ian Morley; Sarracino, David A.; Calderwood, Stephen Beaven; Ryan, Edward Thomas (Public Library of Science, 2009)
      Background: S. Typhi, a human-restricted Salmonella enterica serovar, causes a systemic intracellular infection in humans (typhoid fever). In comparison, S. Typhimurium causes gastroenteritis in humans, but causes a systemic ...

    • Complement Receptor 1 Is a Sialic Acid-Independent Erythrocyte Receptor of Plasmodium falciparum 

      Spadafora, Carmenza; Awandare, Gordon A.; Kopydlowski, Karen M.; Czege, Jozsef; Moch, J. Kathleen; Finberg, Robert W.; Tsokos, George C.; Stoute, José A. (Public Library of Science, 2010)
      Plasmodium falciparum is a highly lethal malaria parasite of humans. A major portion of its life cycle is dedicated to invading and multiplying inside erythrocytes. The molecular mechanisms of erythrocyte invasion are ...

    • A Complex Extracellular Sphingomyelinase of Pseudomonas aeruginosa Inhibits Angiogenesis by Selective Cytotoxicity to Endothelial Cells 

      Vasil, Michael L.; Stonehouse, Martin J.; Vasil, Adriana I.; Wadsworth, Sandra J.; Goldfine, Howard; Bolcome, Robert E.; Chan, Joanne (Public Library of Science, 2009)
      The hemolytic phospholipase C (PlcHR) expressed by Pseudomonas aeruginosa is the original member of a Phosphoesterase Superfamily, which includes phosphorylcholine-specific phospholipases C (PC-PLC) produced by frank and ...

    • Computational and Serologic Analysis of Novel and Known Viruses in Species Human Adenovirus D in Which Serology and Genomics Do Not Correlate 

      Liu, Elizabeth B.; Wadford, Debra A.; Seto, Jason; Vu, Maria; Hudson, Nolan Ryan; Thrasher, Lisa; Torres, Sarah; Dyer, David W.; Seto, Donald; Jones, Morris S.; Chodosh, James (Public Library of Science, 2012)
      In November of 2007 a human adenovirus (HAdV) was isolated from a bronchoalveolar lavage (BAL) sample recovered from a biopsy of an AIDS patient who presented with fever, cough, tachycardia, and expiratory wheezes. To ...

    • Conceptualizing Integration: A Framework for Analysis Applied to Neglected Tropical Disease Control Partnerships 

      Grépin, Karen A.; Reich, Michael Robin (Public Library of Science, 2008)

    • Contributions of Mamu-A*01 Status and TRIM5 Allele Expression, But Not CCL3L Copy Number Variation, to the Control of SIVmac251 Replication in Indian-Origin Rhesus Monkeys 

      Chan, Tiffany; O'Brien, Kara L.; Goldstein, David B.; Haynes, Barton F.; Malik, Harmit S.; Lim, So-Yon; Gelman, Rebecca Sue; Whitney, James B.; Barouch, Dan Hung; Letvin, Norman Lee (Public Library of Science, 2010)
      CCL3 is a ligand for the HIV-1 co-receptor CCR5. There have recently been conflicting reports in the literature concerning whether CCL3-like gene (CCL3L) copy number variation (CNV) is associated with resistance to HIV-1 ...

    • Control and Manipulation of Pathogens with an Optical Trap for Live Cell Imaging of Intercellular Interactions 

      Tam, Jenny M.; Castro, Carlos E.; Heath, Robert John William; Cardenas, Michael L.; Xavier, Ramnik; Lang, Matthew J.; Vyas, Jatin Mahesh (Public Library of Science, 2010)
      The application of live cell imaging allows direct visualization of the dynamic interactions between cells of the immune system. Some preliminary observations challenge long-held beliefs about immune responses to microorganisms; ...

    • COPI Activity Coupled with Fatty Acid Biosynthesis is Required for Viral Replication 

      Cherry, Sara; Kunte, Amit; Wang, Hui; Coyne, Carolyn; Rawson, Robert B; Perrimon, Norbert (Public Library of Science, 2006)
      During infection by diverse viral families, RNA replication occurs on the surface of virally induced cytoplasmic membranes of cellular origin. How this process is regulated, and which cellular factors are required, has ...

    • Cost-effectiveness of alternative blood-screening strategies for West Nile virus in the United States 

      Korves, Caroline T; Goldie, Sue J.; Murray, Megan Blanche (Public Library of Science, 2006)
      Background: West Nile virus (WNV) is endemic in the US, varying seasonally and by geographic region. WNV can be transmitted by blood transfusion, and mandatory screening of blood for WNV was recently introduced throughout ...

    • Cost-Effectiveness of HIV Testing Referral Strategies among Tuberculosis Patients in India 

      Uhler, Lauren M.; Kumarasamy, Nagalingeswaran; Saxena, Anjali; Muniyandi, Malaisamy; Stoler, Adam W.; Lu, Zhigang; Flanigan, Timothy P.; Bender, Melissa A.; Swaminathan, Soumya; Mayer, Kenneth H.; Losina, Elena; Walensky, Rochelle P.; Freedberg, Kenneth Alan; Swaminathan, Soumya (Public Library of Science, 2010)
      Background: Indian guidelines recommend routine referral for HIV testing of all tuberculosis (TB) patients in the nine states with the highest HIV prevalence, and selective referral for testing elsewhere. We assessed the ...

    • Cost-Effectiveness of Preventing Loss to Follow-up in HIV Treatment Programs: A Côte d'Ivoire Appraisal 

      Touré, Hapsatou; Uhler, Lauren M.; Anglaret, Xavier; Paltiel, A. David; Balestre, Eric; Messou, Eugène; Dabis, François; Losina, Elena; Walensky, Rochelle P.; Weinstein, Milton C.; Freedberg, Kenneth Alan (Public Library of Science, 2009)
      Background: Data from HIV treatment programs in resource-limited settings show extensive rates of loss to follow-up (LTFU) ranging from 5% to 40% within 6 mo of antiretroviral therapy (ART) initiation. Our objective was ...

    • Cost-Effectiveness of Treating Multidrug-Resistant Tuberculosis 

      Resch, Stephen C; Salomon, Joshua A.; Murray, Megan Blanche; Weinstein, Milton C. (Public Library of Science, 2006)
      Background: Despite the existence of effective drug treatments, tuberculosis (TB) causes 2 million deaths annually worldwide. Effective treatment is complicated by multidrug-resistant TB (MDR TB) strains that respond only ...

    • A Critical Role for CD8 T Cells in a Nonhuman Primate Model of Tuberculosis 

      Chen, Crystal Y.; Shen, Ling; Zeng, Gucheng; Yao, Shuyun; Shen, Yun; Halliday, Lisa; Fortman, Jeff; McAllister, Milton; Estep, Jim; Vasconcelos, Daphne; Du, George; Porcelli, Steven A.; Larsen, Michelle H.; Jacobs, William R.; Haynes, Barton F.; Letvin, Norman Lee; Huang, Dan; Wang, Richard; Hunt, Robert; Chen, Zheng-Yi (Public Library of Science, 2009)
      The role of CD8 T cells in anti-tuberculosis immunity in humans remains unknown, and studies of CD8 T cell–mediated protection against tuberculosis in mice have yielded controversial results. Unlike mice, humans and nonhuman ...

    • Cross-Sectional Analysis of Late HAART Initiation in Latin America and the Caribbean: Late Testers and Late Presenters 

      Caro-Vega, Yanink; Shepherd, Bryan E.; Wehbe, Firas; Cesar, Carina; Padgett, Denis; Gotuzzo, Eduardo; Cahn, Pedro; McGowan, Catherine; Masys, Daniel; Sierra-Madero, Juan; Crabtree-Ramirez, Brenda; Cortes, Claudia; Koenig, Serena Patricia; CCASAnet Team (Public Library of Science, 2011)
      Background: Starting HAART in a very advanced stage of disease is assumed to be the most prevalent form of initiation in HIV-infected subjects in developing countries. Data from Latin America and the Caribbean is still ...

    • A Crucial Role for Kupffer Cell-Derived Galectin-9 in Regulation of T Cell Immunity in Hepatitis C Infection 

      Mengshol, John A.; Golden-Mason, Lucy; Arikawa, Tomohiro; Smith, Maxwell; Niki, Toshiro; McWilliams, Ryan; Randall, Jessica A.; McMahan, Rachel; Zimmerman, Michael A.; Dobrinskikh, Evgenia; Busson, Pierre; Polyak, Stephen J.; Hirashima, Mitsuomi; Rosen, Hugo R.; Rangachari, Manu V. (Public Library of Science, 2010)
      Approximately 200 million people throughout the world are infected with hepatitis C virus (HCV). One of the most striking features of HCV infection is its high propensity to establish persistence (∼70–80%) and progressive ...

    • Cytomegalovirus Infection Causes an Increase of Arterial Blood Pressure 

      Cheng, Jilin; Ke, Qingen; Jin, Zhuang; Wang, Haibin; Kocher, Olivier Nicolas; Morgan, James P.; Zhang, Jielin; Crumpacker, Clyde S. (Public Library of Science, 2009)
      Cytomegalovirus (CMV) infection is a common infection in adults (seropositive 60–99% globally), and is associated with cardiovascular diseases, in line with risk factors such as hypertension and atherosclerosis. Several ...

    • Cytomegalovirus-Specific T Cells Persist at Very High Levels during Long-Term Antiretroviral Treatment of HIV Disease 

      Naeger, David M.; Martin, Jeffrey Michael; Sinclair, Elizabeth; Hunt, Peter K.; Bangsberg, David Roy; Hecht, Frederick; Hsue, Priscilla; McCune, Joseph M.; Deeks, Steven G. (Public Library of Science, 2010)
      Background: In healthy, HIV seronegative, CMV seropositive adults, a large proportion of T cells are CMV-specific. High-level CMV-specific T cell responses are associated with accelerated immunologic aging (‘‘immunosenesence’’) ...

    • Determinants of Glycan Receptor Specificity of H2N2 Influenza A Virus Hemagglutinin 

      Viswanathan, Karthik; Koh, Xiaoying; Chandrasekaran, Aarthi; Pappas, Claudia; Raman, Rahul; Srinivasan, Aravind; Shriver, Zachary; Tumpey, Terrence M.; Sasisekharan, Ram (Public Library of Science, 2010)
      The H2N2 subtype of influenza A virus was responsible for the Asian pandemic of 1957-58. However, unlike other subtypes that have caused pandemics such as H1N1 and H3N2, which continue to circulate among humans, H2N2 stopped ...

    • Diminishing Availability of Publicly Funded Slots for Antiretroviral Initiation Among HIV-Infected ART-Eligible Patients in Uganda 

      Geng, Elvin H.; Bwana, Mwebesa B.; Kabakyenga, Jerome; Muyindike, Winnie; Emenyonu, Nneka I.; Musinguzi, Nicholas; Mugyenyi, Peter; Myer, Landon; Martin, Jeffrey N.; Bangsberg, David Roy (Public Library of Science, 2010)
      Background: The impact of flat-line funding in the global scale up of antiretroviral therapy (ART) for HIV-infected patients in Africa has not yet been well described. Methods: We evaluated ART-eligible patients and patients ...

    • DNA Damage and Reactive Nitrogen Species are Barriers to Vibrio cholerae Colonization of the Infant Mouse Intestine 

      Davies, Bryan William; Bogard, Ryan; Dupes, Nicole M.; Gerstenfeld, Tyler A. I.; Simmons, Lyle A.; Mekalanos, John J. (Public Library of Science, 2011)
      Ingested Vibrio cholerae pass through the stomach and colonize the small intestines of its host. Here, we show that V. cholerae requires at least two types of DNA repair systems to efficiently compete for colonization of ...