Browsing HMS Scholarly Articles by Keyword "systems biology"

Now showing items 21-30 of 30

    • Protein Dynamics in Individual Human Cells: Experiment and Theory 

      Cohen, Ariel Aharon; Kalisky, Tomer; Mayo, Avi; Geva-Zatorsky, Naama; Danon, Tamar; Issaeva, Irina; Perzov, Natalie; Sigal, Alex; Alon, Uri; Isalan, Mark; Kopito, Ronen; Milo, Ron (Public Library of Science, 2009)
      A current challenge in biology is to understand the dynamics of protein circuits in living human cells. Can one define and test equations for the dynamics and variability of a protein over time? Here, we address this ...

    • A Quantitative Systems View of the Spindle Assembly Checkpoint 

      Ciliberto, Andrea; Shah, Jagesh V. (Nature Publishing Group, 2009)
      The idle assembly checkpoint acts to delay chromosome segregation until all duplicated sister chromatids are captured by the mitotic spindle. This pathway ensures that each daughter cell receives a complete copy of the ...

    • Rectal 1% Tenofovir Gel Use Associates with Altered Epidermal Protein Expression 

      Romas, Laura; Birse, Kenzie; Mayer, Kenneth H.; Abou, Max; Westmacott, Garrett; Giguere, Rebecca; Febo, Irma; Cranston, Ross D.; Carballo-Diéguez, Alex; McGowan, Ian; Burgener, Adam (Mary Ann Liebert, Inc., 2016)
      Abstract Rectal use of a 1% tenofovir (TFV) gel is currently being evaluated for HIV prevention. While careful assessment of mucosal safety of candidate microbicides is a primary concern, tools to assess mucosal toxicity ...

    • Rule-Based Cell Systems Model of Aging using Feedback Loop Motifs Mediated by Stress Responses 

      Kriete, Andres; Bosl, William; Booker, Glenn (Public Library of Science, 2010)
      Investigating the complex systems dynamics of the aging process requires integration of a broad range of cellular processes describing damage and functional decline co-existing with adaptive and protective regulatory ...

    • Segmentation of Multi-Isotope Imaging Mass Spectrometry Data for Semi-Automatic Detection of Regions of Interest 

      Gormanns, Philipp; Reckow, Stefan; Poczatek, J. Collin; Turck, Christoph W.; Lechene, Claude P. (Public Library of Science, 2012)
      Multi-isotope imaging mass spectrometry (MIMS) associates secondary ion mass spectrometry (SIMS) with detection of several atomic masses, the use of stable isotopes as labels, and affiliated quantitative image-analysis ...

    • Systems approach to the study of brain damage in the very preterm newborn 

      Leviton, Alan; Gressens, Pierre; Wolkenhauer, Olaf; Dammann, Olaf (Frontiers Media S.A., 2015)
      Background:: A systems approach to the study of brain damage in very preterm newborns has been lacking. Methods:: In this perspective piece, we offer encephalopathy of prematurity as an example of the complexity and ...

    • Systems biology approaches for the study of multiple sclerosis 

      Quintana, Francisco J; Farez, Mauricio F; Weiner, Howard L (Blackwell Publishing Ltd, 2008)
      Multiple sclerosis (MS) is a progressive neurological disease caused by an autoimmune attack to the central nervous system (CNS). MS is thought to result from a complex interaction between genetic and environmental factors. ...

    • Systems-Level Modeling of Cancer-Fibroblast Interaction 

      Wadlow, Raymond C; Wittner, Ben; Finley, S. Aidan; Bergquist, Henry; Upadhyay, Rabi; Finn, Stephen; Loda, Massimo; Mahmood, Umar; Ramaswamy, Sridhar (Public Library of Science, 2009)
      Cancer cells interact with surrounding stromal fibroblasts during tumorigenesis, but the complex molecular rules that govern these interactions remain poorly understood thus hindering the development of therapeutic strategies ...

    • Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli 

      Morris, Melody K.; Saez-Rodriguez, Julio; Clarke, David R.; Sorger, Peter Karl; Lauffenburger, Douglas A. (Public Library of Science, 2011)
      Predictive understanding of cell signaling network operation based on general prior knowledge but consistent with empirical data in a specific environmental context is a current challenge in computational biology. Recent ...

    • Transcriptional profiles of leukocyte populations provide a tool for interpreting gene expression patterns associated with high fat diet in mice 

      Swindell, William R.; Johnston, Andrew; Gudjonsson, Johann E. (Public Library of Science, 2010)
      Background: Microarray experiments in mice have shown that high fat diet can lead to elevated expression of genes that are disproportionately associated with immune functions. These effects of high fat (atherogenic) diet ...