Now showing items 10044-10063 of 17918

    • Mania Associated With Antidepressant Treatment: Comprehensive Meta-Analytic Review 

      Vázquez, G.; Tondo, Leonardo; Baldessarini, Ross (Wiley, 2009-12-02)
    • Manipulating Replisome Dynamics to Enhance Lambda Red-Mediated Multiplex Genome Engineering 

      Lajoie, Marc Joseph; Gregg, Christopher; Mosberg, Joshua Adam Weintrob; Washington, G. C.; Church, George McDonald (Oxford University Press, 2012)
      Disrupting the interaction between primase and helicase in Escherichia coli increases Okazaki fragment (OF) length due to less frequent primer synthesis. We exploited this feature to increase the amount of ssDNA at the ...
    • Mannose-Binding Lectin 2 Gene and Risk of Adult Glioma 

      Michaud, Dominique S.; Siddiq, Afshan; Cox, David G.; Backes, Danielle M.; Calboli, Federico C. F.; Sughrue, Michael E.; Gaziano, John Michael; Ma, Jing; Stampfer, Meir; Tworoger, Shelley Slate; Hunter, David J.; Camargo, Carlos Arturo; Parsa, Andrew T. (Public Library of Science, 2013)
      Background and Aims The immune system is likely to play a key role in the etiology of gliomas. Genetic polymorphisms in the mannose-binding lectin gene, a key activator in the lectin complement pathway, have been associated ...
    • Mannose-Binding Lectin Binds to Amyloid \(\beta\) Protein and Modulates Inflammation 

      Larvie, Mykol; Shoup, Timothy M.; Chang, Wei-Chuan; Chigweshe, Lorencia; Hartshorn, Kevan; White, Mitchell R.; Stahl, Gregory L.; Elmaleh, David Raphael; Takahashi, Kazue (Hindawi Publishing Corporation, 2012)
      Mannose-binding lectin (MBL), a soluble factor of the innate immune system, is a pattern recognition molecule with a number of known ligands, including viruses, bacteria, and molecules from abnormal self tissues. In addition ...
    • Mannose-Binding Lectin Deficiency is Associated with Smaller Infarction Size and Favorable Outcome in Ischemic Stroke Patients 

      Osthoff, Michael; Katan, Mira; Fluri, Felix; Bingisser, Roland; Kappos, Ludwig; Steck, Andreas J.; Engelter, Stefan T.; Mueller, Beat; Christ-Crain, Mirjam; Trendelenburg, Marten; Schuetz, Philipp (Public Library of Science, 2011)
      Background: The Mannose-binding lectin (MBL) pathway of complement plays a pivotal role in the pathogenesis of ischemia/reperfusion (I/R) injury after experimental ischemic stroke. As comparable data in human ischemic ...
    • Mannose-Binding Lectin Regulates Host Resistance and Pathology during Experimental Infection with Trypanosoma cruzi 

      Rothfuchs, Antonio Gigliotti; Roffê, Ester; Gibson, Amanda; Cheever, Allen W.; Ezekowitz, R. Alan B.; Takahashi, Kazue; Steindel, Mario; Sher, Alan; Báfica, André (Public Library of Science, 2012)
      Mannose-binding lectin (MBL) is a humoral pattern-recognition molecule important for host defense. Although recent genetic studies suggest an involvement of MBL/MASP2-associated pathways in Chagas’ disease, it is currently ...
    • Manual Wheelchair Skills Training for Community-Dwelling Veterans with Spinal Cord Injury: A Randomized Controlled Trial 

      Kirby, R. Lee; Mitchell, Doug; Sabharwal, Sunil; McCranie, Mark; Nelson, Audrey L. (Public Library of Science, 2016)
      Objectives: To test the hypotheses that community-dwelling veterans with spinal cord injury (SCI) who receive the Wheelchair Skills Training Program (WSTP) in their own environments significantly improve their manual ...
    • Manufacturing an Artificial Intelligence Revolution 

      Katz, Yarden (2017-11-30)
      While the term "Artificial Intelligence" (AI) was coined in the 1950s, in recent years AI has become a focus of attention in mainstream media. Yet the forces behind AI's revival have been unclear. I argue here that the ...
    • Many lncRNAs, 5’UTRs, and pseudogenes are translated and some are likely to express functional proteins 

      Ji, Zhe; Song, Ruisheng; Regev, Aviv; Struhl, Kevin (eLife Sciences Publications, Ltd, 2015)
      Using a new bioinformatic method to analyze ribosome profiling data, we show that 40% of lncRNAs and pseudogene RNAs expressed in human cells are translated. In addition, ~35% of mRNA coding genes are translated upstream ...
    • The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis 

      Nadarajan, Saravanapriah; Mohideen, Firaz; Tzur, Yonatan B; Ferrandiz, Nuria; Crawley, Oliver; Montoya, Alex; Faull, Peter; Snijders, Ambrosius P; Cutillas, Pedro R; Jambhekar, Ashwini; Blower, Michael D; Martinez-Perez, Enrique; Harper, J Wade; Colaiacovo, Monica P (eLife Sciences Publications, Ltd, 2016)
      Asymmetric disassembly of the synaptonemal complex (SC) is crucial for proper meiotic chromosome segregation. However, the signaling mechanisms that directly regulate this process are poorly understood. Here we show that ...
    • MAPK activation and HRAS mutation identified in pituitary spindle cell oncocytoma 

      Miller, Michael B.; Bi, Wenya Linda; Ramkissoon, Lori A.; Kang, Yun Jee; Abedalthagafi, Malak; Knoff, David S.; Agarwalla, Pankaj K.; Wen, Patrick Y.; Reardon, David A.; Alexander, Brian M.; Laws, Edward R.; Dunn, Ian F.; Beroukhim, Rameen; Ligon, Keith L.; Ramkissoon, Shakti H. (Impact Journals LLC, 2016)
      Pituitary spindle cell oncocytoma (SCO) is an uncommon primary pituitary neoplasm that presents with mass effect on adjacent neurovascular structures, similar to non-hormone-producing pituitary adenomas. To determine the ...
    • MAPPER: A Search Engine for the Computational Identification of Putative Transcription Factor Binding Sites in Multiple Genomes 

      Marinescu, Voichita D; Kohane, Isaac Samuel; Riva, Alberto (BioMed Central, 2005)
      Background: Cis-regulatory modules are combinations of regulatory elements occurring in close proximity to each other that control the spatial and temporal expression of genes. The ability to identify them in a genome-wide ...
    • Mapping and Characterization of Structural Variation in 17,795 Human Genomes 

      Abel, Haley J.; Larson, David E.; Regier, Allison A.; Chiang, Colby; Das, Indraniel; Kanchi, Krishna L.; Layer, Ryan M.; Neale, Benjamin; Salerno, William J.; Reeves, Catherine; Buyske, Steven; Matise, Tara C.; Muzny, Donna M.; Zody, Michael; Lander, Eric; Dutcher, Susan K.; Stitziel, Nathan; Hall, Ira M. (Cold Spring Harbor Laboratory, 2020-05-27)
      <jats:title>ABSTRACT</jats:title><jats:p>A key goal of whole genome sequencing (WGS) for human genetics studies is to interrogate all forms of variation, including single nucleotide variants (SNV), small insertion/deletion ...
    • Mapping anhedonia onto reinforcement learning: a behavioural meta-analysis 

      Huys, Quentin JM; Pizzagalli, Diego A; Bogdan, Ryan; Dayan, Peter (BioMed Central, 2013)
      Background: Depression is characterised partly by blunted reactions to reward. However, tasks probing this deficiency have not distinguished insensitivity to reward from insensitivity to the prediction errors for reward ...
    • Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis 

      Zhang, Bei; Lin, Pan; Shi, Huqing; Öngür, Dost; Auerbach, Randy P.; Wang, Xiaosheng; Yao, Shuqiao; Wang, Xiang (Springer US, 2015)
      Anhedonia is a prominent symptom in neuropsychiatric disorders, most markedly in major depressive disorder (MDD) and schizophrenia (SZ). Emerging evidence indicates an overlap in the neural substrates of anhedonia between ...
    • Mapping behavioral specifications to model parameters in synthetic biology 

      Koeppl, Heinz; Hafner, Marc; Lu, James (BioMed Central, 2013)
      With recent improvements of protocols for the assembly of transcriptional parts, synthetic biological devices can now more reliably be assembled according to a given design. The standardization of parts open up the way for ...
    • Mapping Community Determinants of Heat Vulnerability 

      Reid, Colleen E.; O’Neill, Marie S.; Gronlund, Carina J.; Brines, Shannon J.; Diez-Roux, Ana V.; Brown, Daniel G.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2009)
      Background: The evidence that heat waves can result in both increased deaths and illness is substantial, and concern over this issue is rising because of climate change. Adverse health impacts from heat waves can be avoided, ...
    • Mapping Connectivity Damage in the Case of Phineas Gage 

      Van Horn, John Darrell; Irimia, Andrei; Torgerson, Carinna M.; Chambers, Micah C.; Kikinis, Ron; Toga, Arthur W. (Public Library of Science, 2012)
      White matter (WM) mapping of the human brain using neuroimaging techniques has gained considerable interest in the neuroscience community. Using diffusion weighted (DWI) and magnetic resonance imaging (MRI), WM fiber ...
    • Mapping cortical anatomy in preschool aged children with autism using surface-based morphometry☆ 

      Raznahan, Armin; Lenroot, Rhoshel; Thurm, Audrey; Gozzi, Marta; Hanley, Allison; Spence, Sarah J.; Swedo, Susan E.; Giedd, Jay N. (Elsevier, 2012)
      The challenges of gathering in-vivo measures of brain anatomy from young children have limited the number of independent studies examining neuroanatomical differences between children with autism and typically developing ...
    • Mapping differential interactomes by affinity purification coupled with data independent mass spectrometry acquisition 

      Lambert, Jean-Philippe; Ivosev, Gordana; Couzens, Amber L.; Larsen, Brett; Taipale, Mikko; Lin, Zhen-Yuan; Zhong, Quan; Lindquist, Susan; Vidal, Marc; Aebersold, Ruedi; Pawson, Tony; Bonner, Ron; Tate, Stephen; Gingras, Anne-Claude (2013)
      Characterizing changes in protein-protein interactions associated with sequence variants (e.g. disease-associated mutations or splice forms) or following exposure to drugs, growth factors or hormones is critical to ...