Browsing HMS Scholarly Articles by Title
Now showing items 1008-1027 of 17918
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Are Statins Anti-Inflammatory?
(BioMed Central, 2000)Large scale clinical trials demonstrate significant reductions in cardiovascular event rates with statin therapy. The observed benefit of statin therapy, however, may be larger in these trials than that expected on the ... -
Are Survey-based Estimates of the Burden of Drug Resistant TB Too Low? Insight from a Simulation Study
(Public Library of Science, 2008)Background: The emergence of tuberculosis resistant to multiple first- and second-line antibiotics poses challenges to a global control strategy that relies on standard drug treatment regimens. Highly drug-resistant strains ... -
Are there mappable genes for family resemblance for the magnitude of intra-individual variation in systolic blood pressure?
(BioMed Central, 2003)Background: The genetic regulation of variation in intra-individual fluctuations in systolic blood pressure over time is poorly understood. Analysis of the magnitude of the average fluctuation of a person's systolic blood ... -
Are ulcers a marker for invasive carcinoma in barrett's esophagus? data from a diagnostic variability study with clinical follow-up
(Springer Nature, 2002)OBJECTIVE: We correlated follow-up information from 138 patients with Barrett's esophagus and varying degrees of dysplasia with the presence of ulcers. METHODS: A group of pathologist participants were asked to contribute ... -
Are We Heeding the Warning Signs? Examining Providers’ Overrides of Computerized Drug-Drug Interaction Alerts in Primary Care
(Public Library of Science, 2013)Background: Health IT can play a major role in improving patient safety. Computerized physician order entry with decision support can alert providers to potential prescribing errors. However, too many alerts can result in ... -
Arenavirus Z protein controls viral RNA synthesis by locking a polymerase–promoter complex
(National Academy of Sciences, 2011)Arenaviruses form a noncytolytic infection in their rodent hosts, yet can elicit severe hemorrhagic disease in humans. How arenaviruses regulate gene expression remains unclear, and further understanding may provide insight ... -
The Arf-like GTPase Arl8b is essential for three-dimensional invasive growth of prostate cancer in vitro and xenograft formation and growth in vivo
(Impact Journals LLC, 2016)Cancer is a multistep process that requires cells to respond appropriately to the tumor microenvironment, both in early proliferative stages and in later invasive disease. Arl8b is a lysosome localized Arf-like GTPase that ... -
ARF1 and GBF1 Generate a PI4P-Enriched Environment Supportive of Hepatitis C Virus Replication
(Public Library of Science, 2012)Cellular levels of phosphatidylinositol 4-phosphate (PI4P) have been shown to be upregulated during RNA replication of several viruses, including the HCV replicon model. However, whether PI4P is required in an infectious ... -
Arginine dependence of tumor cells: targeting a chink in cancer’s armor
(Springer Nature, 2016)Arginine, one among the twenty most common natural amino acids, plays a pivotal role in cellular physiology as it is being involved in numerous cellular metabolic and signaling pathways. Dependence on arginine is diverse ... -
ARID1B is a specific vulnerability in ARID1A-mutant cancers
(2014)Summary Recent studies have revealed that ARID1A is frequently mutated across a wide variety of human cancers and also has bona fide tumor suppressor properties. Consequently, identification of vulnerabilities conferred ... -
Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions
(Dove Medical Press, 2014)Armodafinil is the pharmacologically active R-enantiomer of modafinil, a widely prescribed wake-promoting agent used to treat several sleep-related disorders including excessive daytime sleepiness associated with narcolepsy, ... -
The Aromatase Gene (CYP19A1) Variants and Circulating Hepatocyte Growth Factor in Postmenopausal Women
(Public Library of Science, 2012)Background: Estrogen and androgen have been linked to the regulation of circulating hepatocyte growth factor (HGF), an adipose tissue-derived cytokine. It is possible that the CYP19A1 gene which alters sex hormones production ... -
Aromatase Inhibitors As Adjuvant Therapy for Postmenopausal Women: A Therapeutic Advance But Many Unresolved Questions
(BioMed Central, 2005)Adjuvant hormonal therapy for postmenopausal women with early stage breast cancer has become far more complex over the past several years. This commentary reviews the current status of the five major trials evaluating the ... -
Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression
(BioMed Central, 2012)Introduction: Arthralgias and myalgias are major side effects associated with aromatase inhibitor (AI) therapy of breast cancer. In a recent genome-wide association study, we identified SNPs - including one that created ... -
Arousal vs. Relaxation: A Comparison of the Neurophysiological and Cognitive Correlates of Vajrayana and Theravada Meditative Practices
(Public Library of Science, 2014)Based on evidence of parasympathetic activation, early studies defined meditation as a relaxation response. Later research attempted to categorize meditation as either involving focused or distributed attentional systems. ... -
aRrayLasso: a network-based approach to microarray interconversion
(Oxford University Press, 2015)Summary: Robust conversion between microarray platforms is needed to leverage the wide variety of microarray expression studies that have been conducted to date. Currently available conversion methods rely on manufacturer ... -
Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation: Results from the North American Multidisciplinary Study
(Elsevier BV, 2009)Background: Prior reports on patients with ARVC/D focused on individuals with advanced forms of the disease. There are limited data regarding diagnostic performance of various testing modalities in newly identified individuals ... -
Arsenic is associated with reduced effect of folic acid in myelomeningocele prevention: a case control study in Bangladesh
(BioMed Central, 2015)Background: Arsenic induces neural tube defects in several animal models, but its potential to cause neural tube defects in humans is unknown. Our objective was to investigate the associations between maternal arsenic ... -
Arsenic Trioxide Inhibits Cell Growth and Induces Apoptosis through Inactivation of Notch Signaling Pathway in Breast Cancer
(Molecular Diversity Preservation International (MDPI), 2012)Arsenic trioxide has been reported to inhibit cell growth and induce apoptotic cell death in many human cancer cells including breast cancer. However, the precise molecular mechanisms underlying the anti-tumor activity of ... -
ART adherence changes among patients in community substance use treatment: a preliminary analysis from MACH14
(BioMed Central, 2012)Background: Opiate substitution treatment has been associated with better adherence to lifesaving antiretroviral medications, but the impact of other substance abuse treatment on adherence is unknown. Findings: In this ...