Browsing HMS Scholarly Articles by Title

Now showing items 10084-10103 of 17922

    • MAPRE1 as a Plasma Biomarker for Early-Stage Colorectal Cancer and Adenomas 

      Taguchi, Ayumu; Rho, Jung-hyun; Yan, Qingxiang; Zhang, Yuzheng; Zhao, Yang; Xu, Hanwen; Tripathi, Satyendra Chandra; Wang, Hong; Brenner, Dean E.; Kucherlapati, Melanie; Kucherlapati, Raju; Boutin, Adam T.; Wang, Y. Alan; DePinho, Ronald A.; Feng, Ziding; Lampe, Paul D.; Hanash, Samir M. (American Association for Cancer Research (AACR), 2015-11)
      Blood-based biomarkers for early detection of colorectal cancer (CRC) could complement current approaches to CRC screening. We previously identified the APC-binding protein MAPRE1 as a potential CRC biomarker. Here we ...

    • Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes 

      Wang, Chin-Wei; Colas, Romain; Dalli, Jesmond; Arnardottir, Hildur; Nguyen, Daniel; Hasturk, Hatice; Chiang, Nan; Van Dyke, Thomas E.; Serhan, Charles (American Society for Microbiology, 2016)
      Localized aggressive periodontitis (LAP) is a distinct form of early-onset periodontitis linked to periodontal infection with uncontrolled inflammation and leukocyte-mediated tissue destruction. The resolution of inflammation ...

    • Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective 

      Abdulnour, Raja-Elie; Dalli, Jesmond; Colby, Jennifer; Krishnamoorthy, Nandini; Timmons, Jack; Tan, Sook Hwa; Colas, Romain; Petasis, Nicos; Serhan, Charles; Levy, Bruce (National Academy of Sciences, 2014)
      Unregulated acute inflammation can lead to collateral tissue injury in vital organs, such as the lung during the acute respiratory distress syndrome. In response to tissue injury, circulating platelet-neutrophil aggregates ...

    • Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator from Human Macrophages 

      Deng, Bin; Wang, Chin-Wei; Arnardottir, Hildur H.; Li, Yongsheng; Cheng, Chien-Yee Cindy; Dalli, Jesmond; Serhan, Charles N. (Public Library of Science, 2014)
      Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. Here we identified a novel pro-resolving product, 13R,14S-dihydroxy-docosahexaenoic ...

    • Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages 

      Dalli, Jesmond; Vlasakov, Iliyan; Riley, Ian; Rodriguez, Ana; Spur, Bernd; Petasis, Nicos; Chiang, Nan; Serhan, Charles (National Academy of Sciences, 2016)
      Macrophages are central in coordinating immune responses, tissue repair, and regeneration, with different subtypes being associated with inflammation-initiating and proresolving actions. We recently identified a family of ...

    • Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions 

      Serhan, Charles N.; Yang, Rong; Martinod, Kimberly; Kasuga, Kie; Pillai, Padmini S.; Porter, Timothy F.; Oh, Sungwhan F.; Spite, Matthew (Rockefeller University Press, 2009)
      The endogenous cellular and molecular mechanisms that control acute inflammation and its resolution are of wide interest. Using self-resolving inflammatory exudates and lipidomics, we have identified a new pathway involving ...

    • MARIS: Method for Analyzing RNA following Intracellular Sorting 

      Hrvatin, Siniša; Deng, Francis; O'Donnell, Charles W.; Gifford, David K.; Melton, Douglas A. (Public Library of Science, 2014)
      Transcriptional profiling is a key technique in the study of cell biology that is limited by the availability of reagents to uniquely identify specific cell types and isolate high quality RNA from them. We report a Method ...

    • Marjolin’s ulcer: a preventable malignancy arising from scars 

      Yu, Nanze; Long, Xiao; Lujan-Hernandez, Jorge R; Hassan, Kazi Z; Bai, Ming; Wang, Yang; Wang, Xiaojun; Zhao, Ru (BioMed Central, 2013)
      Background: Marjolin’s ulcer (MU) is a rare malignancy arising from various forms of scars. This potentially fatal complication typically occurs after a certain latency period. This article attempts to reveal the importance ...

    • Markers of Decongestion, Dyspnea Relief, and Clinical Outcomes Among Patients Hospitalized With Acute Heart Failure 

      Kociol, Robb David; McNulty, S. E.; Hernandez, A. F.; Lee, K. L.; Redfield, M. M.; Tracy, R. P.; Braunwald, E.; O, C. M.; Felker, G. M.; undefined, undefined (Ovid Technologies (Wolters Kluwer Health), 2012)
      Background Congestion is a primary driver of symptoms in patients with acute heart failure (AHF), and relief of congestion is a critical goal of therapy. Monitoring of response to therapy through the assessment of daily ...

    • Markers of Skeletal Muscle Mitochondrial Function and Lipid Accumulation Are Moderately Associated with the Homeostasis Model Assessment Index of Insulin Resistance in Obese Men 

      Samjoo, Imtiaz A.; Safdar, Adeel; Hamadeh, Mazen J.; Glover, Alexander W.; Mocellin, Nicholas J.; Santana, Jose; Little, Jonathan P.; Steinberg, Gregory R.; Raha, Sandeep; Tarnopolsky, Mark A. (Public Library of Science, 2013)
      Lower skeletal muscle mitochondrial oxidative phosphorylation capacity (OXPHOS) and intramyocellular lipid (IMCL) accumulation have been implicated in the etiology of insulin resistance (IR) in obesity. The purpose of this ...

    • A Markov chain model for studying suicide dynamics: an illustration of the Rose theorem 

      Yip, Paul Siu Fai; So, Bing Kwan; Kawachi, Ichiro; Zhang, Yi (BioMed Central, 2014)
      Background: High-risk strategies would only have a modest effect on suicide prevention within a population. It is best to incorporate both high-risk and population-based strategies to prevent suicide. This study aims to ...

    • Markov Chain Ontology Analysis (MCOA) 

      Frost, Hildreth Robert; McCray, Alexa T. (BioMed Central, 2012)
      Background: Biomedical ontologies have become an increasingly critical lens through which researchers analyze the genomic, clinical and bibliographic data that fuels scientific research. Of particular relevance are methods, ...

    • Marrying microfluidics and microwells for parallel, high-throughput single-cell genomics 

      Wadsworth, Marc H.; Hughes, Travis K.; Shalek, Alex K. (BioMed Central, 2015)
      An innovative, microwell-based platform for single-cell RNA sequencing (RNA-seq) combines cost efficiency, scalability and parallelizability, and will enable many new avenues of biological inquiry. See related Research ...

    • Mass Production and Size Control of Lipid–Polymer Hybrid Nanoparticles through Controlled Microvortices 

      Kim, YongTae; Lee Chung, Bomy; Ma, Mingming; Mulder, Willem J. M.; Fayad, Zahi A.; Farokhzad, Omid Cameron; Langer, Robert S. (American Chemical Society (ACS), 2012)
      Lipid-polymer hybrid (LPH) nanoparticles can deliver a wide range of therapeutic compounds in a controlled manner. LPH nanoparticle syntheses using microfluidics improve the mixing process, but are restricted by a low ...

    • Mass spectrometry assays of plasma biomarkers to predict radiographic progression of knee osteoarthritis 

      Ritter, Susan Y; Collins, Jamie; Krastins, Bryan; Sarracino, David; Lopez, Mary; Losina, Elena; Aliprantis, Antonios O (BioMed Central, 2014)
      Introduction: Biomarkers to identify osteoarthritis (OA) patients at risk for disease progression are needed. As part of a proteomic analysis of knee synovial fluid from normal and OA patients, differentially expressed ...

    • Mass Spectrometry-Based (GeLC-MS/MS) Comparative Proteomic Analysis of Endoscopically (ePFT) Collected Pancreatic and Gastroduodenal Fluids 

      Paulo, Joao A.; Kadiyala, Vivek; Banks, Peter Alan; Steen, Hanno; Conwell, Darwin Lewis (Nature Publishing Group, 2012)
      Objectives: The secretin-stimulated endoscopic pancreatic function test (ePFT) allows for the safe collection of gastroduodenal and pancreatic fluid from the duodenum. We test the hypothesis that these endoscopically ...

    • Mass Spectrometry-Based Proteomics for Translational Research: A Technical Overview 

      Paulo, Joao A; Kadiyala, Vivek; Banks, Peter Alan; Steen, Hanno; Conwell, Darwin Lewis (Yale University, 2012)
      Mass spectrometry-based investigation of clinical samples enables the high-throughput identification of protein biomarkers. We provide an overview of mass spectrometry-based proteomic techniques that are applicable to the ...

    • Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease 

      Kwong, Gabriel A.; von Maltzahn, Geoffrey; Murugappan, Gayathree; Abudayyeh, Omar; Mo, Steven; Papayannopoulos, Ioannis A.; Sverdlov, Deanna Y.; Liu, Susan B.; Warren, Andrew D.; Popov, Yury; Schuppan, Detlef; Bhatia, Sangeeta N. (2012)
      Biomarkers are increasingly important in the clinical management of complex diseases, yet our ability to discover new biomarkers remains limited by our dependence on endogenous molecules. Here we describe the development ...

    • Mass-Spectrometry-Based Metabolomics: Limitations and Recommendations for Future Progress with Particular Focus on Nutrition Research 

      Scalbert, Augustin; Brennan, Lorraine; Fiehn, Oliver; Hankemeier, Thomas; Kristal, Bruce S.; van Ommen, Ben; Pujos-Guillot, Estelle; Verheij, Elwin; Wishart, David; Wopereis, Suzan (Springer Verlag, 2009)
      Mass spectrometry (MS) techniques, because of their sensitivity and selectivity, have become methods of choice to characterize the human metabolome and MS-based metabolomics is increasingly used to characterize the complex ...

    • The Massachusetts General Hospital Acute Stroke Imaging Algorithm: An Experience and Evidence Based Approach 

      Gonzalez, Ramon Gilberto; Copen, William Alan; Schaefer, Pamela Whitney; Lev, Michael Howard; Pomerantz, Stuart R.; Rapalino, Otto; Chen, John Wen-Yueh; Hunter, George; Romero, Javier M.; Buchbinder, Bradley R.; Larvie, Mykol; Hirsch, Joshua A.; Gupta, Rajiv (BMJ Publishing Group, 2013)
      The Massachusetts General Hospital Neuroradiology Division employed an experience and evidence based approach to develop a neuroimaging algorithm to best select patients with severe ischemic strokes caused by anterior ...