Browsing HMS Scholarly Articles by Title

Now showing items 1339-1358 of 17922

    • Asymptomatic Polyvascular Abnormalities in Community (APAC) Study in China: Objectives, Design and Baseline Characteristics 

      Zhou, Yong; Li, Yang; Xu, Liang; Xu, Jie; Wang, Anxing; Gao, Xiang; Wu, Shouling; Wei, Wen Bin; Zhao, Xingquan; Jonas, Jost B. (Public Library of Science, 2013)
      Objective: The population-based “Asymptomatic Polyvascular Abnormalities in Community (APAC) Study was designed to examine prevalence and associations of asymptomatic polyvascular abnormalities (APA) in a general population. ...

    • At-home COVID-19 testing and the estimated true incidence of confirmed Omicron BA.2 in the United States 

      Rader, Benjamin; Gertz, Autumn; Brownstein, John (2022-08-09)

    • AT-RvD1 Modulates CCL-2 and CXCL-8 Production and NF-κB, STAT-6, SOCS1, and SOCS3 Expression on Bronchial Epithelial Cells Stimulated with IL-4 

      de Oliveira, Jhony Robison; Favarin, Daniely Cornélio; Tanaka, Sarah Cristina Sato Vaz; Balarin, Marly Aparecida Spadotto; Silva Teixeira, David Nascimento; Levy, Bruce David; Rogério, Alexandre de Paula (Hindawi Publishing Corporation, 2015)
      Bronchial epithelial cells represent the first line of defense against microorganisms and allergens in the airways and play an important role in chronic inflammatory processes such as asthma. In an experimental model, both ...

    • ATARiS: Computational quantification of gene suppression phenotypes from multisample RNAi screens 

      Shao, Diane D.; Tsherniak, Aviad; Gopal, Shuba; Weir, Barbara A.; Tamayo, Pablo; Stransky, Nicolas; Schumacher, Steven E.; Zack, Travis I.; Beroukhim, Rameen; Garraway, Levi A.; Margolin, Adam A.; Root, David E.; Hahn, William C.; Mesirov, Jill P. (Cold Spring Harbor Laboratory Press, 2013)
      Genome-scale RNAi libraries enable the systematic interrogation of gene function. However, the interpretation of RNAi screens is complicated by the observation that RNAi reagents designed to suppress the mRNA transcripts ...

    • Ataxia induced by a thymic neuroblastoma in the elderly patient 

      Wiesel, Ory; Bhattacharyya, Shamik; Vaitkevicius, Henrikas; Prasad, Sashank; McNamee, Ciaran (BioMed Central, 2015)
      Thymic neuroblastoma is a rare tumor with only few reports in modern literature. Whereas most data is taken from childhood neuroblastoma, little is known about the characteristics of the disease in the adult and elderly ...

    • Ataxia, Dementia, and Hypogonadotropism Caused by Disordered Ubiquitination 

      Margolin, David H.; Kousi, Maria; Chan, Yee-Ming; Lim, Elaine T.; Schmahmann, Jeremy Dan; Hadjivassiliou, Marios; Hall, Janet E.; Adam, Ibrahim; Dwyer, Andrew; Plummer, Lacey; Aldrin, Stephanie V.; O, Julia; Kirby, Andrew; Lage, Kasper; Milunsky, Aubrey; Milunsky, Jeff M.; Chan, Jennifer Ang; Hedley-Whyte, E. Tessa; Daly, Mark Joseph; Katsanis, Nicholas; Seminara, Stephanie Beth (New England Journal of Medicine (NEJM/MMS), 2013)
      In recent years, we have seen great advances in the elucidation of genetic causes of cerebellar ataxia, with newly identified genes regulating a wide spectrum of cellular functions, including intracellular signaling, tau ...

    • Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism 

      Mandriota, Stefano J.; Valentijn, Linda J.; Lesne, Laurence; Betts, David R.; Marino, Denis; Boudal-Khoshbeen, Mary; London, Wendy B.; Rougemont, Anne-Laure; Attiyeh, Edward F.; Maris, John M.; Hogarty, Michael D.; Koster, Jan; Molenaar, Jan J.; Versteeg, Rogier; Ansari, Marc; Gumy-Pause, Fabienne (Impact Journals LLC, 2015)
      Neuroblastoma, a childhood cancer with highly heterogeneous biology and clinical behavior, is characterized by genomic aberrations including amplification of MYCN. Hemizygous deletion of chromosome 11q is a well-established, ...

    • Atelectasis Induced by Thoracotomy Causes Lung Injury during Mechanical Ventilation in Endotoxemic Rats 

      Choi, Won-Il; Kwon, Kun Young; Kim, Jin Mo; Quinn, Deborah A.; Hales, Charles Albert; Seo, Jeong Wook (The Korean Academy of Medical Sciences, 2008)
      Atelectasis can impair arterial oxygenation and decrease lung compliance. However, the effects of atelectasis on endotoxemic lungs during ventilation have not been well studied. We hypothesized that ventilation at low ...

    • ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis 

      Cohen, Daniel M; Won, Kyoung-Jae; Nguyen, Nha; Lazar, Mitchell A; Chen, Christopher S; Steger, David J (eLife Sciences Publications, Ltd, 2015)
      A well-established cascade of transcription factor (TF) activity orchestrates adipogenesis in response to chemical cues, yet how cell-intrinsic determinants of differentiation such as cell shape and/or seeding density ...

    • The Atg1-Tor Pathway Regulates Yolk Catabolism in Drosophila Embryos 

      Kuhn, Hallie; Sopko, Richelle; Coughlin, Margaret; Perrimon, Norbert; Mitchison, Timothy (The Company of Biologists, 2015-11-15)
      Yolk provides an important source of nutrients during the early development of oviparous organisms. It is composed mainly of vitellogenin proteins packed into membrane-bound compartments called yolk platelets. Catabolism ...

    • Atherogenesis in Mice Does Not Require CD40 Ligand from Bone Marrow-Derived Cells 

      Bavendiek, Udo; Zirlik, Andreas; LaClair, Samantha; MacFarlane, Lindsey Adair; Libby, Peter; Schönbeck, Uwe (American Heart Association, 2005)
      Objective. Recent research suggests a central role for CD40 ligand (CD40L) in atherogenesis. However, the relevant cellular source of this proinflammatory cytokine remains unknown. To test the hypothesis that CD40L expressed ...

    • An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium 

      Li, H.; Cybulsky, M. I.; Gimbrone, Michael Anthony; Libby, Peter (Ovid Technologies (Wolters Kluwer Health), 1993)
      Accumulation of monocyte-derived foam cells in focal areas of the arterial intima is a key step in early atherogenesis. We investigated the expression of vascular cell adhesion molecule-1 (VCAM-1), a mononuclear leukocyte ...

    • Atheromas that cause fatal thrombosis are usually large and frequently accompanied by vessel enlargement 

      Bezerra, Hiram Grando; Higuchi, Maria de Lourdes; Gutierrez, Paulo Sampaio; Palomino, Sueli Aparecida; Silvestre, Julia Maria La Chioma; Libby, Peter; Ramires, José Antonio Franchini (Elsevier BV, 2001)
      Several lines of clinical evidence show that AMI frequently occurs at sites with mild to moderate degree of coronary stenosis. The degree of luminal stenosis depends on plaque deposition and degree of vessel remodeling, ...

    • Atherosclerosis: Successes, Surprises, and Future Challenges 

      Libby, Peter; Bornfeldt, Karin E.; Tall, Alan R. (Ovid Technologies (Wolters Kluwer Health), 2016)
      This new compendium of 16 articles "reviews the current state-of-the-art of atherosclerosis research spanning from a global health perspective to fundamental molecular mechanisms. The editors intend this collection of ...

    • Atherosclerotic Biomarkers and Aortic Atherosclerosis by Cardiovascular Magnetic Resonance Imaging in the Framingham Heart Study 

      Hong, Susie N.; Gona, Philimon; Fontes, Joao D.; Oyama, Noriko; Chan, Raymond H.; Kenchaiah, Satish; Tsao, Connie W.; Yeon, Susan B.; Schnabel, Renate B.; Keaney, John F.; O'Donnell, Christopher J.; Benjamin, Emelia J.; Manning, Warren J. (Blackwell Publishing Ltd, 2013)
      Background: The relations between subclinical atherosclerosis and inflammatory biomarkers have generated intense interest but their significance remains unclear. We sought to determine the association between a panel of ...

    • An Atlas of Genetic Correlations across Human Diseases and Traits 

      Bulik-Sullivan, Brendan; Finucane, Hilary K; Anttila, Verneri; Gusev, Alexander; Day, Felix R.; Loh, Po-Ru; Duncan, Laramie; Perry, John R.B.; Patterson, Nick; Robinson, Elise B.; Daly, Mark J.; Price, Alkes L.; Neale, Benjamin M. (2015)
      Identifying genetic correlations between complex traits and diseases can provide useful etiological insights and help prioritize likely causal relationships. The major challenges preventing estimation of genetic correlation ...

    • Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation 

      Gusev, Alexander; Shi, Huwenbo; Kichaev, Gleb; Pomerantz, Mark; Li, Fugen; Long, Henry W.; Ingles, Sue A.; Kittles, Rick A.; Strom, Sara S.; Rybicki, Benjamin A.; Nemesure, Barbara; Isaacs, William B.; Zheng, Wei; Pettaway, Curtis A.; Yeboah, Edward D.; Tettey, Yao; Biritwum, Richard B.; Adjei, Andrew A.; Tay, Evelyn; Truelove, Ann; Niwa, Shelley; Chokkalingam, Anand P.; John, Esther M.; Murphy, Adam B.; Signorello, Lisa B.; Carpten, John; Leske, M. Cristina; Wu, Suh-Yuh; Hennis, Anslem J. M.; Neslund-Dudas, Christine; Hsing, Ann W.; Chu, Lisa; Goodman, Phyllis J.; Klein, Eric A.; Witte, John S.; Casey, Graham; Kaggwa, Sam; Cook, Michael B.; Stram, Daniel O.; Blot, William J.; Eeles, Rosalind A.; Easton, Douglas; Kote-Jarai, ZSofia; Al Olama, Ali Amin; Benlloch, Sara; Muir, Kenneth; Giles, Graham G.; Southey, Melissa C.; Fitzgerald, Liesel M.; Gronberg, Henrik; Wiklund, Fredrik; Aly, Markus; Henderson, Brian E.; Schleutker, Johanna; Wahlfors, Tiina; Tammela, Teuvo L. J.; Nordestgaard, Børge G.; Key, Tim J.; Travis, Ruth C.; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Pharoah, Paul; Pashayan, Nora; Khaw, Kay-Tee; Stanford, Janet L.; Thibodeau, Stephen N.; McDonnell, Shannon K.; Schaid, Daniel J.; Maier, Christiane; Vogel, Walther; Luedeke, Manuel; Herkommer, Kathleen; Kibel, Adam S.; Cybulski, Cezary; Wokolorczyk, Dominika; Kluzniak, Wojciech; Cannon-Albright, Lisa; Teerlink, Craig; Brenner, Hermann; Dieffenbach, Aida K.; Arndt, Volker; Park, Jong Y.; Sellers, Thomas A.; Lin, Hui-Yi; Slavov, Chavdar; Kaneva, Radka; Mitev, Vanio; Batra, Jyotsna; Spurdle, Amanda; Clements, Judith A.; Teixeira, Manuel R.; Pandha, Hardev; Michael, Agnieszka; Paulo, Paula; Maia, Sofia; Kierzek, Andrzej; Cook, Margaret; Guy, Michelle; Govindasami, Koveela; Leongamornlert, Daniel; Sawyer, Emma J.; Wilkinson, Rosemary; Saunders, Edward J.; Tymrakiewicz, Malgorzata; Dadaev, Tokhir; Morgan, Angela; Fisher, Cyril; Hazel, Steve; Livni, Naomi; Lophatananon, Artitaya; Pedersen, John; Hopper, John L.; Adolfson, Jan; Stattin, Paer; Johansson, Jan-Erik; Cavalli-Bjoerkman, Carin; Karlsson, Ami; Broms, Michael; Auvinen, Anssi; Kujala, Paula; Maeaettaenen, Liisa; Murtola, Teemu; Taari, Kimmo; Weischer, Maren; Nielsen, Sune F.; Klarskov, Peter; Roder, Andreas; Iversen, Peter; Wallinder, Hans; Gustafsson, Sven; Cox, Angela; Brown, Paul; George, Anne; Marsden, Gemma; Lane, Athene; Davis, Michael; Tillmans, Lori; Riska, Shaun; Wang, Liang; Rinckleb, Antje; Lubiski, Jan; Stegmaier, Christa; Pow-Sang, Julio; Park, Hyun; Radlein, Selina; Rincon, Maria; Haley, James; Zachariah, Babu; Kachakova, Darina; Popov, Elenko; Mitkova, Atanaska; Vlahova, Aleksandrina; Dikov, Tihomir; Christova, Svetlana; Heathcote, Peter; Wood, Glenn; Malone, Greg; Saunders, Pamela; Eckert, Allison; Yeadon, Trina; Kerr, Kris; Collins, Angus; Turner, Megan; Srinivasan, Srilakshmi; Kedda, Mary-Anne; Alexander, Kimberly; Omara, Tracy; Wu, Huihai; Henrique, Rui; Pinto, Pedro; Santos, Joana; Barros-Silva, Joao; Conti, David V.; Albanes, Demetrius; Berg, Christine; Berndt, Sonja I.; Campa, Daniele; Crawford, E. David; Diver, W. Ryan; Gapstur, Susan M.; Gaziano, J. Michael; Giovannucci, Edward; Hoover, Robert; Hunter, David J.; Johansson, Mattias; Kraft, Peter; Le Marchand, Loic; Lindström, Sara; Navarro, Carmen; Overvad, Kim; Riboli, Elio; Siddiq, Afshan; Stevens, Victoria L.; Trichopoulos, Dimitrios; Vineis, Paolo; Yeager, Meredith; Trynka, Gosia; Raychaudhuri, Soumya; Schumacher, Frederick R.; Price, Alkes L.; Freedman, Matthew L.; Haiman, Christopher A.; Pasaniuc, Bogdan (Nature Publishing Group, 2016)
      Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data ...

    • Atlas-Guided Segmentation of Vervet Monkey Brain MRI 

      Fedorov, Andriy; Li, Xiaoxing; Pohl, Kilian M; Bouix, Sylvain; Styner, Martin; Addicott, Merideth; Wyatt, Chris; Daunais, James B; Wells, William Mercer; Kikinis, Ron (Bentham Science, 2011)
      The vervet monkey is an important nonhuman primate model that allows the study of isolated environmental factors in a controlled environment. Analysis of monkey MRI often suffers from lower quality images compared with ...

    • ATM-deficient Thymic Lymphoma is Associated with Aberrant tcrd Rearrangement and Gene Amplification 

      Bassing, Craig H.; Brush, James W.; Patel, Harin; Goff, Peter H.; Gatti, Richard A.; Zha, Shan; Sanda, Takaomi; Murphy, Michael M.; Tepsuporn, Suprawee; Look, A. Thomas; Alt, Frederick W. (The Rockefeller University Press, 2010)
      Ataxia telangiectasia mutated (ATM) deficiency predisposes humans and mice to T lineage lymphomas with recurrent chromosome 14 translocations involving the T cell receptor α/δ (Tcra/d) locus. Such translocations have been ...

    • Atomic structure reveals the unique capsid organization of a dsRNA virus 

      Pan, Junhua; Dong, Liping; Lin, Li; Ochoa, Wendy F.; Sinkovits, Robert S.; Havens, Wendy M.; Nibert, Max L.; Baker, Timothy S.; Ghabrial, Said A.; Tao, Yizhi Jane (National Academy of Sciences, 2009)
      For most dsRNA viruses, the genome-enclosing capsid comprises 120 copies of a single capsid protein (CP) organized into 60 icosahedrally equivalent dimers, generally identified as 2 nonsymmetrically interacting CP molecules ...