Browsing HMS Scholarly Articles by Title

Now showing items 1359-1378 of 17920

    • Atorvastatin Therapy is Associated with Greater and Faster Cerebral Hemodynamic Response 

      Xu, Guofan; Fitzgerald, Michele E.; Wen, Zhifei; Fain, Sean B.; Alsop, David; Carroll, Timothy; Ries, Michele L.; Rowley, Howard A.; Sager, Mark A.; Asthana, Sanjay; Johnson, Sterling C.; Carlsson, Cynthia M. (Springer Science and Business Media LLC, 2008-06)
      Hypercholesterolemia in midlife increases the risk of subsequent cognitive decline, neurovascular disease, and Alzheimer’s disease (AD), and statin use is associated with reduced prevalence of these outcomes. While statins ...

    • Atorvastatin upregulates regulatory T cells and reduces clinical disease activity in patients with rheumatoid arthritis 

      Tang, Ting-Ting; Song, You; Ding, Ying-Jun; Liao, Yu-Hua; Yu, Xian; Du, Rong; Xiao, Hong; Yuan, Jing; Zhou, Zi-Hua; Liao, Meng-Yang; Yao, Rui; Jevallee, Harish; Shi, Guo-Ping; Cheng, Xiang (American Society for Biochemistry and Molecular Biology, 2011)
      In this study, we investigated the hypothesis that regulatory T cells (T-reg) are involved in the immunomodulatory effects of statins on rheumatoid arthritis (RA) patients. The 12-week study cohort consisted of 55 RA ...

    • ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content 

      Nowyhed, Heba N.; Chandra, Shilpi; Kiosses, William; Marcovecchio, Paola; Andary, Farah; Zhao, Meng; Fitzgerald, Michael L.; Kronenberg, Mitchell; Hedrick, Catherine C. (Nature Publishing Group, 2017)
      ABCA7 is an ABC transporter expressed on the plasma membrane, and actively exports phospholipid complexes from the cytoplasmic to the exocytoplasmic leaflet of membranes. Invariant NKT (iNKT) cells are a subpopulation of ...

    • ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis 

      Luo, Bin; Wang, Minggang; Hou, Nengyi; Hu, Xiao; Jia, Guiqing; Qin, Xianpeng; Zuo, Xiaofei; Liu, Yang; Luo, Kun; Song, Wei; Wang, Kang; Pang, Minghui (Neoplasia Press, 2016)
      Helicobacter pylori infection is the strongest risk factor for development of gastric cancer. Host cellular stress responses, including inflammatory and immune responses, have been reported highly linked to H. pylori-induced ...

    • ATP1A3 Mutation in Adult Rapid-Onset Ataxia 

      Sweadner, Kathleen J.; Toro, Camilo; Whitlow, Christopher T.; Snively, Beverly M.; Cook, Jared F.; Ozelius, Laurie J.; Markello, Thomas C.; Brashear, Allison (Public Library of Science, 2016)
      A 21-year old male presented with ataxia and dysarthria that had appeared over a period of months. Exome sequencing identified a de novo missense variant in ATP1A3, the gene encoding the α3 subunit of Na,K-ATPase. Several ...

    • ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction 

      Hodi, F. Stephen; Schmollinger, Jan C.; Soiffer, Robert J.; Salgia, Ravi; Lynch, Thomas; Ritz, Jerome; Alyea, Edwin P.; Yang, Jihong; Neuberg, Donna; Mihm, Martin; Dranoff, Glenn (National Academy of Sciences, 2002)
      An important goal of cancer immunology is the identification of antigens associated with tumor destruction. Vaccination with irradiated tumor cells engineered to secrete granulocyte/macrophage colony-stimulating factor ...

    • The ATPase Module of Mammalian SWI/SNF Family Complexes Mediates Subcomplex Identity and Catalytic Activity–independent Genomic Targeting 

      Mashtalir, Nazar; Wang, Lu; Kadoch, Cigall; Pan, Joshua; McKenzie, Zachary; D’Avino, Andrew; Lareau, Caleb; St. Pierre, Roodolph; Shilatifard, Ali (Springer Science and Business Media LLC, 2019-03-11)
      Perturbations to mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complexes have been widely implicated as driving events in cancer1. One such perturbation is the dual loss of the SMARCA4 and SMARCA2 ATPase subunits in ...

    • Atrial natriuretic peptide is negatively regulated by microRNA-425 

      Arora, Pankaj; Wu, Connie; Khan, Abigail May; Bloch, Donald Bendit; Davis-Dusenbery, Brandi Nicole; Ghorbani, Anahita; Spagnolli, Ester; Martinez, Andrew; Ryan, Allicia; Tainsh, Laurel T.; Kim, Samuel M; Rong, Jian; Huan, Tianxiao; Freedman, Jane E.; Levy, Daniel; Miller, Karen Klahr; Hata, Akiko; Del Monte, Federica; Vandenwijngaert, Sara; Swinnen, Melissa; Janssens, Stefan; Holmes, Tara M.; Buys, Emmanuel; Bloch, Kenneth Daniel; Newton-Cheh, Christopher Holmes; Wang, Thomas (American Society for Clinical Investigation, 2013)
      Numerous common genetic variants have been linked to blood pressure, but no underlying mechanism has been elucidated. Population studies have revealed that the variant rs5068 (A/G) in the 3′ untranslated region of NPPA, ...

    • Atrial Septum Fat Deposition and Atrial Anatomy Assessed by Cardiac Magnetic Resonance: Relationship to Atrial Electrophysiology 

      Rizzi, Patricia B; Mewton, Nathan; Tereshchencko, Larisa G; Strauss, David G; Liu, Chia-Ying; Marchlinski, Francis E; Spooner, Peter M; Kellman, Peter; Lima, Joao A; Verrier, Richard Leonard; Cox, Christopher; Nearing, Bruce David (BioMed Central, 2012)
      To assess the prevalence of fat deposition in the atrial septum with and its relationship with 12-lead electrocardiogram (ECG) atrial parameters (PR interval, P wave duration) and the presence of atrial fibrillation.

    • Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women 

      Kim, Hye Won; Kim, Yang-Hyun; Han, Kyungdo; Nam, Ga Eun; Kim, Gwang Seon; Han, Byoung-Duck; Lee, Anna; Ahn, Ji Yong; Ko, Byung Joon (Public Library of Science, 2014)
      Purpose Osteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of ...

    • Atropine for Critical Care Intubation in a Cohort of 264 Children and Reduced Mortality Unrelated to Effects on Bradycardia 

      Jones, Peter; Peters, Mark J.; Pinto da Costa, Nathalia; Kurth, Tobias; Alberti, Corinne; Kessous, Katia; Lode, Noella; Dauger, Stephane (Public Library of Science, 2013)
      Background: Atropine has is currently recommended to facilitate haemodynamic stability during critical care intubation. Our objective was to determine whether atropine use at induction influences ICU mortality. ...

    • Attachment disorganization and controlling behavior in middle childhood: maternal and child precursors and correlates 

      Bureau, Jean François; Ann Easlerbrooks, M.; Lyons-Ruth, Karlen (Informa UK Limited, 2009)
      Main, Kaplan, and Cassidy's (1985) conceptualizations of disorganization in infancy and controlling behavior in preschool forged new directions in attachment research. However, there currently is no valid coding system for ...

    • Attachment Studies with Borderline Patients: A Review 

      Agrawal, Hans R.; Gunderson, John Gunder; Holmes, Bjarne M.; Lyons-Ruth, Karlen (Ovid Technologies (Wolters Kluwer Health), 2004)
      Clinical theorists have suggested that disturbed attachments are central to borderline personality disorder (BPD) psychopathology. This article reviews 13 empirical studies that examine the types of attachment found in ...

    • Attachment, Neurobiology, and Mentalizing along the Psychosis Continuum 

      Debbané, Martin; Salaminios, George; Luyten, Patrick; Badoud, Deborah; Armando, Marco; Solida Tozzi, Alessandra; Fonagy, Peter; Brent, Benjamin K. (Frontiers Media S.A., 2016)
      In this review article, we outline the evidence linking attachment adversity to psychosis, from the premorbid stages of the disorder to its clinical forms. To better understand the neurobiological mechanisms through which ...

    • Attack Rates Assessment of the 2009 Pandemic H1N1 Influenza A in Children and Their Contacts: A Systematic Review and Meta-Analysis 

      Glatman-Freedman, Aharona; Portelli, Ian; Jacobs, Susan K.; Mathew, Justin I.; Slutzman, Jonathan Evan; Goldfrank, Lewis R.; Smith, Silas W. (Public Library of Science, 2012)
      Background: The recent H1N1 influenza A pandemic was marked by multiple reports of illness and hospitalization in children, suggesting that children may have played a major role in the propagation of the virus. A comprehensive ...

    • Attention is fast but volition is slow 

      Wolfe, Jeremy; Alvarez, George; Horowitz, Todd (Springer Nature, 2000-08)
      How swiftly can the object of your attention be changed? Consider two ways to deploy attention: it can be commanded from place to place by a deliberate act of will, or it can run freely without specific instruction. Here ...

    • Attention-driven auditory cortex short-term plasticity helps segregate relevant sounds from noise 

      Ahveninen, Jyrki; Hämäläinen, Matti; Jääskeläinen, Iiro P.; Ahlfors, Seppo P.; Huang, Samantha; Lin, Fa-Hsuan; Raij, Tommi; Sams, Mikko; Vasios, Christos E.; Belliveau, John W. (National Academy of Sciences, 2011)
      How can we concentrate on relevant sounds in noisy environments? A "gain model" suggests that auditory attention simply amplifies relevant and suppresses irrelevant afferent inputs. However, it is unclear whether this ...

    • Attentional Control and Intelligence: MRI Orbital Frontal Gray Matter and Neuropsychological Correlates 

      Nestor, Paul G.; Nakamura, Motoaki; Niznikiewicz, Margaret; Levitt, James J.; Newell, Dominick T.; Shenton, Martha E.; McCarley, Robert W. (Hindawi Publishing Corporation, 2015)
      Attentional control is a key function of working memory that is hypothesized to play an important role in psychometric intelligence. To test the neuropsychological underpinnings of this hypothesis, we examined full-scale ...

    • Attentional Load Effects on Beta Oscillations in Healthy and Schizophrenic Individuals 

      Ghorashi, Shahab; Spencer, Kevin M. (Frontiers Media S.A., 2015)
      Attentional deficits are prominent among the cognitive disturbances found in schizophrenia. Given that schizophrenia is also characterized by abnormalities in high-frequency oscillations, we investigated whether attentional ...

    • Attentional modulation of emotional stimulus processing: An fMRI study using emotional expectancy 

      Bermpohl, Felix; Pascual-Leone, Alvaro; Amedi, Amir; Merabet, Lotfi B; Fregni, Felipe; Gaab, Nadine; Alsop, David C.; Schlaug, Gottfried; Northoff, Georg (Wiley-Blackwell, 2006)
      We used emotional expectancy to study attentional modulation in the processing of emotional stimuli. During functional magnetic resonance imaging (fMRI), volunteers saw emotional and neutral expectancy cues signaling the ...