Browsing HMS Scholarly Articles by Title

Now showing items 1469-1488 of 17922

    • Autonomous Sheet Pile Driving Robots for Soil Stabilization 

      Melenbrink, Nathan; Werfel, Justin (IEEE, 2019)
      Abstract— Soil stabilization is a fundamental component of nearly all construction projects, ranging from commercial construction to environmental restoration projects. Previous work in autonomous construction has generally ...

    • Autonomous Vascular Networks Synchronize GABA Neuron Migration in the Embryonic Forebrain 

      Won, Chungkil; Lin, Zhicheng; Kumar T, Peeyush; Li, Suyan; Ding, Lai; Elkhal, Abdallah; Szabó, Gábor; Vasudevan, Anju (2013)
      GABA neurons, born in remote germinative zones in the ventral forebrain (telencephalon), migrate tangentially in two spatially distinct streams to adopt their specific positions in the developing cortex. The cell types and ...

    • Autonomous Zinc-Finger Nuclease Pairs for Targeted Chromosomal Deletion 

      Şöllü, Cem; Pars, Kaweh; Cornu, Tatjana I.; Thibodeau-Beganny, Stacey; Maeder, Morgan L.; Joung, Jae Keith; Heilbronn, Regine; Cathomen, Toni (Oxford University Press, 2010)
      Zinc-finger nucleases (ZFNs) have been successfully used for rational genome engineering in a variety of cell types and organisms. ZFNs consist of a non-specific FokI endonuclease domain and a specific zinc-finger DNA-binding ...

    • Autopalmitoylation of TEAD Proteins Regulates Transcriptional Output of Hippo Pathway 

      Chan, PuiYee; Han, Xiao; Zheng, Baohui; DeRan, Michael; Yu, Jianzhong; Jarugumilli, Gopala K.; Deng, Hua; Pan, Duojia; Luo, Xuelian; Wu, Xu (2016)
      TEA domain (TEAD) transcription factors bind to the co-activator YAP/TAZ, and regulate the transcriptional output of Hippo pathway, playing critical roles in organ size control and tumorigenesis. Protein S-palmitoylation ...

    • Autophagic Cell Death and Apoptosis Jointly Mediate Cisatracurium Besylate-Induced Cell Injury 

      Zhuang, Haixia; Tian, Weili; Li, Wen; Zhang, Xingli; Wang, Jingjing; Yang, Yue; Liu, Xin; Xia, Zhengyuan; Feng, Du; Zhang, Liangqing (MDPI, 2016)
      Cisatracurium besylate is an ideal non-depolarizing muscle relaxant which is widely used in clinical application. However, some studies have suggested that cisatracurium besylate can affect cell proliferation. Moreover, ...

    • Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice 

      Vodicka, Petr; Chase, Kathryn; Iuliano, Maria; Tousley, Adelaide; Valentine, Dana T.; Sapp, Ellen; Kegel-Gleason, Kimberly B.; Sena-Esteves, Miguel; Aronin, Neil; DiFiglia, Marian (IOS Press, 2016)
      Background: Mutant huntingtin (mHTT) is encoded by the Huntington’s disease (HD) gene and its accumulation in the brain contributes to HD pathogenesis. Reducing mHTT levels through activation of the autophagosome-lysosomal ...

    • Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer 

      Buffen, Kathrin; Oosting, Marije; Quintin, Jessica; Ng, Aylwin; Kleinnijenhuis, Johanneke; Kumar, Vinod; van de Vosse, Esther; Wijmenga, Cisca; van Crevel, Reinout; Oosterwijk, Egbert; Grotenhuis, Anne J.; Vermeulen, Sita H.; Kiemeney, Lambertus A.; van de Veerdonk, Frank L.; Chamilos, Georgios; Xavier, Ramnik J.; van der Meer, Jos W. M.; Netea, Mihai G.; Joosten, Leo A. B. (Public Library of Science, 2014)
      The anti-tuberculosis-vaccine Bacillus Calmette-Guérin (BCG) is the most widely used vaccine in the world. In addition to its effects against tuberculosis, BCG vaccination also induces non-specific beneficial effects against ...

    • Autophagy Correlates with the Therapeutic Responsiveness of Malignant Pleural Mesothelioma in 3D Models 

      Barbone, Dario; Follo, Carlo; Echeverry, Nohemy; Gerbaudo, Victor H.; Klabatsa, Astero; Bueno, Raphael; Felley-Bosco, Emanuela; Broaddus, V. Courtney (Public Library of Science, 2015)
      Malignant pleural mesothelioma is a highly chemoresistant solid tumor. We have studied this apoptotic resistance using in vitro and ex vivo three-dimensional models, which acquire a high level of chemoresistance that can ...

    • Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis 

      Wei, Jun; Long, Lingyun; Yang, Kai; Guy, Cliff; Shrestha, Sharad; Chen, Zuojia; Wu, Chuan; Vogel, Peter; Neale, Geoffrey; Green, Douglas R; Chi, Hongbo (2015)
      Regulatory T (Treg) cells respond to immune and inflammatory signals to mediate immunosuppression, but how functional integrity of Treg cells is maintained under activating environments remains elusive. Here we found that ...

    • Autophagy in Idiopathic Pulmonary Fibrosis 

      Patel, Avignat Suresh; Lin, Ling; Geyer, Alexander; Haspel, Jeffrey Adam; An, Chang Hyeok; Cao, Jiaofei; Rosas, Ivan O.; Morse, Danielle (Public Library of Science, 2012)
      Background: Autophagy is a basic cellular homeostatic process important to cell fate decisions under conditions of stress. Dysregulation of autophagy impacts numerous human diseases including cancer and chronic obstructive ...

    • Autophagy in Lysosomal Storage Disorders 

      Lieberman, Andrew P.; Puertollano, Rosa; Raben, Nina; Slaugenhaupt, Susan Ann; Walkley, Steven U.; Ballabio, Andrea (Landes Bioscience, 2012)
      Lysosomes are ubiquitous intracellular organelles that have an acidic internal pH, and play crucial roles in cellular clearance. Numerous functions depend on normal lysosomes, including the turnover of cellular constituents, ...

    • Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach 

      Nah, Jihoon; Yuan, Junying; Jung, Yong-Keun (Korean Society for Molecular and Cellular Biology, 2015)
      Autophagy is a lysosome-dependent intracellular degradation process that allows recycling of cytoplasmic constituents into bioenergetic and biosynthetic materials for maintenance of homeostasis. Since the function of ...

    • Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I 

      Yamamoto, Keisuke; Venida, Anthony; Yano, Julian; Biancur, Douglas E.; Kakiuchi, Miwako; Gupta, Suprit; Sohn, Albert S. W.; Mukhopadhyay, Subhadip; Lin, Elaine Y.; Parker, Seth J.; Banh, Robert S.; Paulo, Joao A.; Wen, Kwun Wah; Debnath, Jayanta; Kim, Grace E.; Mancias, Joseph D.; Fearon, Douglas T.; Perera, Rushika M.; Kimmelman, Alec C. (Springer Science and Business Media LLC, 2020-04-22)
      Immune evasion through impaired antigen presentation contributes to the growth and spread of many cancers1. Common mechanisms for immune evasion include mutations or loss of heterozygosity (LOH) of the major histocompatibility ...

    • Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10 

      Finton, Kathryn A. K.; Larimore, Kevin; Larman, H. Benjamin; Friend, Della; Correnti, Colin; Rupert, Peter B.; Elledge, Stephen J.; Greenberg, Philip D.; Strong, Roland K. (Public Library of Science, 2013)
      The broadly-neutralizing anti-HIV antibody 4E10 recognizes an epitope in the membrane-proximal external region of the HIV envelope protein gp41. Previous attempts to elicit 4E10 by vaccination with envelope-derived or ...

    • Autoreactivity to Glucose Regulated Protein 78 Links Emphysema and Osteoporosis in Smokers 

      Bon, Jessica; Kahloon, Rehan; Zhang, Yingze; Xue, Jianmin; Fuhrman, Carl R.; Tan, Jiangning; Burger, Mathew; Kass, Daniel J.; Csizmadia, Eva; Otterbein, Leo; Chandra, Divay; Bhargava, Arpit; Pilewski, Joseph M.; Roodman, G. David; Sciurba, Frank C.; Duncan, Steven R. (Public Library of Science, 2014)
      Rationale: Emphysema and osteoporosis are epidemiologically associated diseases of cigarette smokers. The causal mechanism(s) linking these illnesses is unknown. We hypothesized autoimmune responses may be involved in both ...

    • Autosomal Dominant Distal Renal Tubular Acidosis Is Associated in Three Families with Heterozygosity for the R589H Mutation in the AE1 (Band 3) Cl − /HCO 3 − Exchanger 

      Jarolim, Petr; Shayakul, Chairat; Prabakaran, Daniel; Jiang, Lianwei; Stuart-Tilley, Alan; Rubin, Hillard L.; Simova, Sarka; Zavadil, Jiri; Herrin, John T.; Brouillette, John; Somers, Michael J. G.; Seemanova, Eva; Brugnara, Carlo; Guay-Woodford, Lisa M.; Alper, Seth L. (American Society for Biochemistry and Molecular Biology, 1998)

    • Autosomal Dominant Hypocalcemia (Hypoparathyroidism) Types 1 and 2 

      Roszko, Kelly L.; Bi, Ruiye D.; Mannstadt, Michael (Frontiers Media S.A., 2016)
      Extracellular calcium is essential for life and its concentration in the blood is maintained within a narrow range. This is achieved by a feedback loop that receives input from the calcium-sensing receptor (CASR), expressed ...

    • Autosomal Monoallelic Expression in the Mouse 

      Zwemer, Lillian M; Zak, Alexander; Thompson, Benjamin R; Kirby, Andrew; Daly, Mark Joseph; Chess, Andrew; Gimelbrant, Alexander (BioMed Central, 2012)
      Background: Random monoallelic expression defines an unusual class of genes displaying random choice for expression between the maternal and paternal alleles. Once established, the allele-specific expression pattern is ...

    • Autotransporters but not pAA are critical for rabbit colonization by Shiga toxin-producing Escherichia coli O104:H4 

      Munera, Diana; Ritchie, Jennifer M; Hatzios, Stavroula K; Bronson, Rod; Fang, Gang; Schadt, Eric E; Davis, Brigid M; Waldor, Matthew K (2014)
      The outbreak of diarrhea and hemolytic uremic syndrome that occurred in Germany in 2011 was caused by a Shiga toxin-producing enteroaggregative Escherichia coli (EAEC) strain. The strain was classified as EAEC due to the ...

    • Autworks: a Cross-Disease Network Biology Application for Autism and Related Disorders 

      Nelson, Tristan; Jung, Jae-Yoon; DeLuca, Todd; Hinebaugh, Byron Kent; St Gabriel, Kristian Che; Wall, Dennis Paul Paul (BioMed Central, 2012)
      Background: The genetic etiology of autism is heterogeneous. Multiple disorders share genotypic and phenotypic traits with autism. Network based cross-disorder analysis can aid in the understanding and characterization of ...