Browsing HMS Scholarly Articles by Title
Now showing items 1529-1548 of 17922
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Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection
(Public Library of Science, 2015)Staphylococcus aureus is capable of infecting nearly every organ in the human body. In order to infiltrate and thrive in such diverse host tissues, staphylococci must possess remarkable flexibility in both metabolic and ... -
Bacterial Metabolic State More Accurately Predicts Antibiotic Lethality Than Growth Rate
(Springer Science and Business Media LLC, 2019-08-26)Growth rate and metabolic state have been separately shown to affect antibiotic efficacy1–3. However, the two are interrelated since bacterial growth inherently imposes a metabolic burden4; thus, determining individual ... -
Bacterial protein translocation requires only one copy of the SecY complex in vivo
(The Rockefeller University Press, 2012)The transport of proteins across the plasma membrane in bacteria requires a channel formed from the SecY complex, which cooperates with either a translating ribosome in cotranslational translocation or the SecA ATPase in ... -
A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals
(eLife Sciences Publications, Ltd, 2012)Bacterially-produced small molecules exert profound influences on animal health, morphogenesis, and evolution through poorly understood mechanisms. In one of the closest living relatives of animals, the choanoflagellate ... -
Bacterial vaginosis and adverse outcomes among full-term infants: a cohort study
(BioMed Central, 2016)Background: Bacterial vaginosis (BV) during pregnancy is a well-established risk factor for preterm birth and other preterm pregnancy complications. Little is known about adverse neonatal outcomes associated with BV exposure ... -
Bacteriophage T7 DNA polymerase – sequenase
(Frontiers Media S.A., 2014)An ideal DNA polymerase for chain-terminating DNA sequencing should possess the following features: (1) incorporate dideoxy- and other modified nucleotides at an efficiency similar to that of the cognate deoxynucleotides; ... -
Bacteriophages and Phage-Inspired Nanocarriers for Targeted Delivery of Therapeutic Cargos
(Elsevier BV, 2016-11)The main goal of drug delivery systems is to target therapeutic cargoes to desired cells and to ensure their efficient uptake. Recently a number of studies have focused on designing bio-inspired nanocarriers, such as ... -
Bacteroidales Secreted Antimicrobial Proteins Target Surface Molecules Necessary for Gut Colonization and Mediate Competition In Vivo
(American Society for Microbiology, 2016)ABSTRACT We recently showed that human gut Bacteroidales species secrete antimicrobial proteins (BSAPs), and we characterized in vitro the first such BSAP produced by Bacteroides fragilis. In this study, we identified a ... -
Bactobolin Resistance Is Conferred by Mutations in the L2 Ribosomal Protein
(American Society of Microbiology, 2012)Burkholderia thailandensis produces a family of polyketide-peptide molecules called bactobolins, some of which are potent antibiotics. We found that growth of B. thailandensis at 30°C versus that at 37°C resulted in increased ... -
BAL1 and Its Partner E3 Ligase, BBAP, Link Poly(ADP-Ribose) Activation, Ubiquitylation, and Double-Strand DNA Repair Independent of ATM, MDC1, and RNF8
(American Society for Microbiology, 2013)The BAL1 macrodomain-containing protein and its partner E3 ligase, BBAP, are overexpressed in chemotherapy-resistant lymphomas. BBAP selectively ubiquitylates histone H4 and indirectly promotes early 53BP1 recruitment to ... -
Balancing Antiplatelet and Anticoagulant Therapies in Patients with Cardiovascular Disease
(Springer Healthcare, 2013)Anticoagulation is needed for stroke prevention in patients with atrial fibrillation. Antiplatelet therapy is essential for the prevention of stent thrombosis and the reduction of cardiovascular events in patients who ... -
Balancing Education and Service in Graduate Medical Education: Data From Pediatric Trainees and Program Directors
(Published for the Association of American Medical Colleges by Lippincott Williams & Wilkins, 2014)Purpose To measure pediatric program directors’ (PDs’) and trainees’ perceptions of and expectations for the balance of service and education in their training programs. Method In fall 2011, an electronic survey was sent ... -
Balancing Image Quality and Compression Factor for Special Stains Whole Slide Images
(IOS Press, 2012)The objective is to find a practical balance between quality and performance for daily high volume whole slide imaging. We evaluated whole slide images created by various scanners at different compression factors to determine ... -
Balancing Selection on a Regulatory Region Exhibiting Ancient Variation That Predates Human–Neandertal Divergence
(Public Library of Science, 2013)Ancient population structure shaping contemporary genetic variation has been recently appreciated and has important implications regarding our understanding of the structure of modern human genomes. We identified a ∼36-kb ... -
Balancing speed and accuracy of polyclonal T cell activation: A role for extracellular feedback
(BioMed Central, 2012)Background: Extracellular feedback is an abundant module of intercellular communication networks, yet a detailed understanding of its role is still lacking. Here, we study interactions between polyclonal activated T cells ... -
Barcoding Bias in High-Throughput Multiplex Sequencing of miRNA
(Cold Spring Harbor Laboratory, 2011-09)Second-generation sequencing is gradually becoming the method of choice for miRNA detection and expression profiling. Given the relatively small number of miRNAs and improvements in DNA sequencing technology, studying miRNA ... -
Barcoding cells using cell-surface programmable DNA-binding domains
(2013)We develop here a novel approach to barcode large numbers of cells through cell-surface expression of programmable zinc-finger DNA-binding domains (sZFs). We show sZFs enable double-stranded DNA to sequence-specifically ... -
Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials
(BMJ Publishing Group Ltd., 2013)Objective: To quantify the overall effects of bariatric surgery compared with non-surgical treatment for obesity. Design: Systematic review and meta-analysis based on a random effects model. Data sources Searches of Medline, ... -
Barrier-to-Autointegration Factor 1 (BAF/BANF1) Promotes Association of the SETD1A Histone Methyltransferase with Herpes Simplex Virus Immediate-Early Gene Promoters
(American Society of Microbiology, 2015)ABSTRACT We have shown previously that A-type lamins and intranuclear localization of the herpes simplex virus (HSV) genome are critical for the formation of the VP16 activator complex on HSV immediate-early (IE) gene ...