Browsing HMS Scholarly Articles by Title

Now showing items 1613-1632 of 17922

    • Beta-Synemin Expression in Cardiotoxin-Injected Rat Skeletal Muscle 

      Mizuno, Yuji; Guyon, Jeffrey R; Ishii, Akiko; Hoshino, Sachiko; Ohkoshi, Norio; Tamaoka, Akira; Okamoto, Koichi; Kunkel, Louis Martens (BioMed Central, 2007)
      Background: β-synemin was originally identified in humans as an α-dystrobrevin-binding protein through a yeast two-hybrid screen using an amino acid sequence derived from exons 1 through 16 of α-dystrobrevin, a region ...

    • \(\beta\)-Cell Hyperplasia Induced by Hepatic Insulin Resistance 

      Escribano, Oscar; Guillén, Carlos; Nevado, Carmen; Gómez-Hernández, Almudena; Kahn, C. Ronald; Benito, Manuel (American Diabetes Association, 2009)
      Objective: Type 2 diabetes results from a combination of insulin resistance and impaired insulin secretion. To directly address the effects of hepatic insulin resistance in adult animals, we developed an inducible ...

    • BETASCAN: Probable \(\beta\)-amyloids Identified by Pairwise Probabilistic Analysis 

      Bryan, Allen Wayne; Menke, Matthew; Cowen, Lenore J.; Lindquist, Susan L.; Berger, Bonnie (Public Library of Science, 2009)
      Amyloids and prion proteins are clinically and biologically important \(\beta\)-structures, whose supersecondary structures are difficult to determine by standard experimental or computational means. In addition, significant ...

    • Bethesda Categorization of Thyroid Nodule Cytology and Prediction of Thyroid Cancer Type and Prognosis 

      Liu, Xiaoyun; Medici, Marco; Kwong, Norra; Angell, Trevor; Marqusee, Ellen; Kim, Matthew; P. Reed Larsen; Cho, Nancy; Nehs, Matthew; Ruan, Daniel; Gawande, Atul Atmaram::3861be84cf2aae828a65939fc165d5c0::600; Moore, Francis; Jr.; Barletta, Justine; Krane, Jeffrey; Cibas, Edmund; Yang, Tao; Alexander, Erik (2016)
      Background: Since its inception, the Bethesda System for Reporting Thyroid Cytopathology (TBS) has been widely adopted. Each category conveys a risk of malignancy and recommended next steps, though it is unclear if each ...

    • Bevacizumab for Progressive Vestibular Schwannoma in Neurofibromatosis Type 2 

      Plotkin, Scott Randall; Merker, Vanessa; Halpin, Chris; Jennings, Dominique; McKenna, Michael John; Harris, Gordon J.; Barker, Frederick George (Ovid Technologies (Wolters Kluwer Health), 2012)
      Objective: Early studies suggest that bevacizumab treatment can result in tumor shrinkage and hearing improvement for some patients with neurofibromatosis type 2 (NF2). The aim of this study was to report extended follow-up ...

    • Bevacizumab terminates homeobox B9-induced tumor proliferation by silencing microenvironmental communication 

      Hoshino, Yoshinori; Hayashida, Tetsu; Hirata, Akira; Takahashi, Hidena; Chiba, Naokazu; Ohmura, Mitsuyo; Wakui, Masatoshi; Jinno, Hiromitsu; Hasegawa, Hirotoshi; Maheswaran, Shyamala; Suematsu, Makoto; Kitagawa, Yuko (BioMed Central, 2014)
      Background: Homeobox B9 (HOXB9), a transcriptional factor, regulates developmental processes and tumor progression and has recently been recognized as one of important transcriptional factors related to angiogenesis. This ...

    • Bevacizumab Treatment for Meningiomas in NF2: A Retrospective Analysis of 15 Patients 

      Nunes, Fabio; Merker, Vanessa L.; Jennings, Dominique; Caruso, Paul Albert; di Tomaso, Emmanuelle; Muzikansky, Alona; Barker, Frederick George; Stemmer-Rachamimov, Anat; Plotkin, Scott Randall (Public Library of Science (PLoS), 2013)
      Bevacizumab treatment can result in tumor shrinkage of progressive vestibular schwannomas in some neurofibromatosis 2 (NF2) patients but its effect on meningiomas has not been defined. To determine the clinical activity ...

    • Bevacizumab treatment for symptomatic spinal ependymomas in neurofibromatosis type 2 

      Farschtschi, S.; Merker, V. L.; Wolf, D.; Schuhmann, M.; Blakeley, J.; Plotkin, Scott Randall; Hagel, C.; Mautner, V. F. (Wiley-Blackwell, 2015)
      Background Neurofibromatosis type 2 (NF2) is a tumor suppressor syndrome associated with vestibular schwannomas, meningiomas, and spinal ependymomas. There have been anecdotal reports of radiographic response of spinal ...

    • Beyond BMI: The “Metabolically healthy obese” phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review 

      Roberson, Lara L; Aneni, Ehimen C; Maziak, Wasim; Agatston, Arthur; Feldman, Theodore; Rouseff, Maribeth; Tran, Thinh; Blaha, Michael J; Santos, Raul D; Sposito, Andrei; Al-Mallah, Mouaz H; Blankstein, Ron; Budoff, Matthew J; Nasir, Khurram (BioMed Central, 2014)
      Background: A subgroup has emerged within the obese that do not display the typical metabolic disorders associated with obesity and are hypothesized to have lower risk of complications. The purpose of this review was to ...

    • Beyond Crossing Fibers: Bootstrap Probabilistic Tractography Using Complex Subvoxel Fiber Geometries 

      Campbell, Jennifer S. W.; MomayyezSiahkal, Parya; Savadjiev, Peter; Leppert, Ilana R.; Siddiqi, Kaleem; Pike, G. Bruce (Frontiers Media S.A., 2014)
      Diffusion magnetic resonance imaging fiber tractography is a powerful tool for investigating human white matter connectivity in vivo. However, it is prone to false positive and false negative results, making interpretation ...

    • Beyond descriptive research: advancing the study of spirituality and health 

      Rosmarin, David Hillel; Wachholtz, Amy; Ai, Amy (Springer Science + Business Media, 2011)
      The past three decades have witnessed a surge in research on spirituality and health. This growing body of literature has linked many aspects of spirituality as well as religion to both positive and negative indices of ...

    • Beyond Hepatocellular Carcinoma and Colorectal Metastasis: The Expanding Applications of Radioembolization 

      Zurkiya, Omar; Ganguli, Suvranu (Frontiers Media S.A., 2014)
      As a relatively safe outpatient procedure, radioembolization can potentially be used to treat any type of tumor within the liver, primary or metastatic. The safety and effectiveness of radioembolization in the treatment ...

    • Beyond PET/CT in Hodgkin lymphoma: a comprehensive review of the role of imaging at initial presentation, during follow-up and for assessment of treatment-related complications 

      Keraliya, Abhishek R.; Tirumani, Sree Harsha; Shinagare, Atul B.; Ramaiya, Nikhil H. (Springer Berlin Heidelberg, 2015)
      Objective: The purpose of this article is to provide a comprehensive review of the role of imaging modalities other than PET/CT in the management of Hodgkin lymphoma (HL). PET/CT is the imaging modality of choice in the ...

    • Beyond the amygdala: Linguistic threat modulates peri-sylvian semantic access cortices 

      Weisholtz, Daniel; Root, James C.; Butler, Tracy; Tüscher, Oliver; Epstein, Jane Ingrid; Pan, Hong; Protopopescu, Xenia; Goldstein, Martin; Isenberg, Nancy; Brendel, Gary; LeDoux, Joseph; Silbersweig, David A; Stern, Emily (Elsevier BV, 2015)
      In this study, healthy volunteers were scanned using functional magnetic resonance imaging (fMRI) to investigate the neural systems involved in processing the threatening content conveyed via visually presented “threat ...

    • Beyond type 2 diabetes, obesity and hypertension: an axis including sleep apnea, left ventricular hypertrophy, endothelial dysfunction, and aortic stiffness among Mexican Americans in Starr County, Texas 

      Hanis, Craig L.; Redline, Susan; Cade, Brian E.; Bell, Graeme I.; Cox, Nancy J.; Below, Jennifer E.; Brown, Eric L.; Aguilar, David (BioMed Central, 2016)
      Background: There is an increasing appreciation for a series of less traditional risk factors that should not be ignored when considering type 2 diabetes, obesity, hypertension, and cardiovascular disease. These include ...

    • Beyond VEGF—The Weisenfeld Lecture 

      Miller, Joan W. (The Association for Research in Vision and Ophthalmology, 2016)
      Purpose To review advances made in the treatment of age-related macular degeneration (AMD) and share perspectives on the future of AMD treatment. Methods: Review of published clinical and experimental studies. Results: ...

    • Bias in the physical examination of patients with lumbar radiculopathy 

      Suri, Pradeep; Hunter, David J; Katz, Jeffrey; Li, Ling; Rainville, James (Springer Science and Business Media LLC, 2010-11-30)
      Background: No prior studies have examined systematic bias in the musculoskeletal physical examination. The objective of this study was to assess the effects of bias due to prior knowledge of lumbar spine magnetic resonance ...

    • Biased Multicomponent Reactions to Develop Novel Bromodomain Inhibitors 

      McKeown, Michael R; Shaw, Daniel L; Fu, Harry; Liu, Shuai; Xu, Xiang; Marineau, Jason J; Huang, Yibo; Zhang, Xiaofeng; Buckley, Dennis L; Kadam, Asha; Zhang, Zijuan; Blacklow, Stephen C; Qi, Jun; Zhang, Wei; Bradner, James E (American Chemical Society, 2014)
      BET bromodomain inhibition has contributed new insights into gene regulation and emerged as a promising therapeutic strategy in cancer. Structural analogy of early methyl-triazolo BET inhibitors has prompted a need for ...

    • Biasogram: Visualization of Confounding Technical Bias in Gene Expression Data 

      Krzystanek, Marcin; Szallasi, Zoltan; Eklund, Aron C. (Public Library of Science, 2013)
      Gene expression profiles of clinical cohorts can be used to identify genes that are correlated with a clinical variable of interest such as patient outcome or response to a particular drug. However, expression measurements ...

    • BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models 

      Li, D; Ambrogio, L; Shimamura, T; Kubo, S; Takahashi, M; Chirieac, Lucian; Padera, Robert; Shapiro, Geoffrey; Baum, A; Himmelsbach, F; Rettig, W J; Meyerson, Matthew; Solca, F; Greulich, Heidi; Wong, K-K (Springer Science and Business Media LLC, 2008-04-14)
      Genetic alterations in the kinase domain of the epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) patients are associated with sensitivity to treatment with small molecule tyrosine kinase ...