Browsing HMS Scholarly Articles by Title

Now showing items 1653-1672 of 17922

    • Binding Affinities among DNA Helicase-Primase, DNA Polymerase, and Replication Intermediates in the Replisome of Bacteriophage T7 

      Zhang, Huidong; Tang, Yong; Lee, Seung-Joo; Wei, Zeliang; Cao, Jia; Richardson, Charles (American Society for Biochemistry and Molecular Biology, 2016)
      The formation of a replication loop on the lagging strand facilitates coordinated synthesis of the leading-and lagging-DNA strands and provides a mechanism for recycling of the lagging- strand DNA polymerase. As an Okazaki ...

    • Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles 

      Tassa, Carlos; Duffner, Jay L.; Lewis, Timothy A.; Weissleder, Ralph; Schreiber, Stuart L.; Koehler, Angela N.; Shaw, Stanley Y. (American Chemical Society, 2010)
      Nanoparticles bearing surface-conjugated targeting ligands are increasingly being explored for it variety of biomedical applications. The multivalent conjugation of targeting ligands on the surface of nanoparticles is ...

    • Binding of herpes simplex virus-1 US11 to specific RNA sequences 

      Bryant, Kevin F.; Cox, J. Colin; Wang, Hongming; Hogle, James M.; Ellington, Andrew D.; Coen, Donald M. (Oxford University Press, 2005)
      Herpes simplex virus-1 US11 is a RNA-binding protein with a novel RNA-binding domain. US11 has been reported to exhibit sequence- and conformation-specific RNA-binding, but the sequences and conformations important for ...

    • Binding Parameters and Thermodynamics of the Interaction of the Human Cytomegalovirus DNA Polymerase Accessory Protein, UL44, with DNA: Implications for the Processivity Mechanism 

      Loregian, Arianna; Sinigalia, Elisa; Mercorelli, Beatrice; Palù, Giorgio; Coen, Donald Mark (Oxford University Press, 2007)
      The mechanisms of processivity factors of herpesvirus DNA polymerases remain poorly understood. The proposed processivity factor for human cytomegalovirus DNA polymerase is a DNA-binding protein, UL44. Previous findings, ...

    • A Bio-Inspired Swellable Microneedle Adhesive for Mechanical Interlocking with Tissue 

      Yang, Seung Yun; O'Cearbhaill, Eoin D.; Sisk, Geoffroy C.; Park, Kyeng Min; Cho, Woo Kyung; Villiger, Martin; Bouma, Brett E.; Pomahac, Bohdan; Karp, Jeffrey M. (2013)
      Achieving significant adhesion to soft tissues while minimizing tissue damage poses a considerable clinical challenge. Chemical-based adhesives require tissue-specific reactive chemistry, typically inducing a significant ...

    • Bio-Photonic Detection and Quantitative Evaluation Method for the Progression of Dental Caries Using Optical Frequency-Domain Imaging Method 

      Wijesinghe, Ruchire Eranga; Cho, Nam Hyun; Park, Kibeom; Jeon, Mansik; Kim, Jeehyun (MDPI, 2016)
      The initial detection of dental caries is an essential biomedical requirement to barricade the progression of caries and tooth demineralization. The objective of this study is to introduce an optical frequency-domain imaging ...

    • Bioabsorbable polymer optical waveguides for deep-tissue photomedicine 

      Nizamoglu, Sedat; Gather, Malte C.; Humar, Matjaž; Choi, Myunghwan; Kim, Seonghoon; Kim, Ki Su; Hahn, Sei Kwang; Scarcelli, Giuliano; Randolph, Mark; Redmond, Robert W.; Yun, Seok Hyun (Nature Publishing Group, 2016)
      Advances in photonics have stimulated significant progress in medicine, with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical utility. ...

    • Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson’s Disease 

      Smirnova, Natalya A.; Kaidery, Navneet Ammal; Hushpulian, Dmitry M.; Rakhman, Ilay I.; Poloznikov, Andrey A.; Tishkov, Vladimir I.; Karuppagounder, Saravanan S.; Gaisina, Irina N.; Pekcec, Anton; Leyen, Klaus Van; Kazakov, Sergey V.; Yang, Lichuan; Thomas, Bobby; Ratan, Rajiv R.; Gazaryan, Irina G. (JKL International LLC, 2016)
      Flavonoids are known to trigger the intrinsic genetic adaptive programs to hypoxic or oxidative stress via estrogen receptor engagement or upstream kinase activation. To reveal specific structural requirements for direct ...

    • Bioavailable Vitamin D Is More Tightly Linked to Mineral Metabolism than Total Vitamin D in Incident Hemodialysis Patients 

      Bhan, Ishir; Powe, Camille Elise; Berg, Anders Hayden; Ankers, Elizabeth; Wenger, Julia; Karumanchi, Subbian Ananth; Thadhani, Ravi Ishwar (Nature Publishing Group, 2012)
      Prior studies showed conflicting results regarding the association between 25-hydroxyvitamin D (25(OH)D) levels and mineral metabolism in end-stage renal disease. In order to determine whether the bioavailable vitamin D ...

    • A BioBrick compatible strategy for genetic modification of plants 

      Boyle, Patrick M; Burrill, Devin Rene; Inniss, Mara Christine; Agapakis, Christina M; Deardon, Aaron; dewerd, Jonathan G; Gedeon, Michael A; Quinn, Jacqueline Y; Paull, Morgan L; Raman, Anugraha M; Theilmann, Mark R; Wang, Lu; Winn, Julia C; Medvedik, Oliver; Schellenberg, Kurt William; Haynes, Karmella; Viel, Alain; Brenner, Tamara Jane; Church, George McDonald; Shah, Jagesh V.; Silver, Pamela A. (BioMed Central, 2012)
      Background: Plant biotechnology can be leveraged to produce food, fuel, medicine, and materials. Standardized methods advocated by the synthetic biology community can accelerate the plant design cycle, ultimately making ...

    • BioC: a minimalist approach to interoperability for biomedical text processing 

      Comeau, Donald C.; Islamaj Doğan, Rezarta; Ciccarese, Paolo; Cohen, Kevin Bretonnel; Krallinger, Martin; Leitner, Florian; Lu, Zhiyong; Peng, Yifan; Rinaldi, Fabio; Torii, Manabu; Valencia, Alfonso; Verspoor, Karin; Wiegers, Thomas C.; Wu, Cathy H.; Wilbur, W. John (Oxford University Press, 2013)
      A vast amount of scientific information is encoded in natural language text, and the quantity of such text has become so great that it is no longer economically feasible to have a human as the first step in the search ...

    • Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins 

      McLaughlin-Drubin, Margaret E.; Munger, Karl (MDPI, 2013)
      The role of enzymes involved in polycomb repression of gene transcription has been studied extensively in human cancer. Polycomb repressive complexes mediate oncogene-induced senescence, a principal innate cell-intrinsic ...

    • Biochemical Characterization of Novel Retroviral Integrase Proteins 

      Ballandras-Colas, Allison; Naraharisetty, Hema; Li, Xiang; Serrao, Erik; Engelman, Alan (Public Library of Science, 2013)
      Integrase is an essential retroviral enzyme, catalyzing the stable integration of reverse transcribed DNA into cellular DNA. Several aspects of the integration mechanism, including the length of host DNA sequence duplication ...

    • Biochemical Phenotypes to Discriminate Microbial Subpopulations and Improve Outbreak Detection 

      Galar, Alicia; Kulldorff, Martin; Rudnick, Wallis; O'Brien, Thomas F.; Stelling, John (Public Library of Science, 2013)
      Background: Clinical microbiology laboratories worldwide constitute an invaluable resource for monitoring emerging threats and the spread of antimicrobial resistance. We studied the growing number of biochemical tests ...

    • Biochemical, Biophysical, and Mutational Analyses of Subunit Interactions of the Human Cytomegalovirus Nuclear Egress Complex 

      Sam, My; Evans, Brady; Coen, Donald; Hogle, James (American Society for Microbiology, 2009)
      Nuclear egress, the trafficking of herpesvirus nucleocapsids from the nucleus to the cytoplasm, involves two conserved viral proteins that form a complex at the nuclear envelope, referred to as the nuclear egress complex. ...

    • Biocompatibility and biofilm inhibition of N,N-hexyl,methyl-polyethylenimine bonded to Boston Keratoprosthesis materials 

      Behlau, Irmgard; Mukherjee, Koushik; Todani, Amit; Tisdale, Ann S.; Cade, Fabiano; Wang, Liqiang; Leonard, Elizabeth M.; Zakka, Fouad R.; Gilmore, Michael S.; Jakobiec, Frederick A.; Dohlman, Claes Henrik; Klibanov, Alexander M. (Elsevier BV, 2011)
      The biocompatibility and antibacterial properties of N,N-hexyl,methyl-polyethylenimine (HMPEI) covalently attached to the Boston Keratoprosthesis (B-KPro) materials was evaluated. By means of confocal and electron microscopies, ...

    • Biocompatible Pressure Sensing Skins for Minimally Invasive Surgical Instruments 

      Arabagi, Veaceslav; Felfoul, Ouajdi; Gosline, Andrew H.; Wood, Robert J.; Dupont, Pierre E (Institute of Electrical and Electronics Engineers (IEEE), 2016)
      Kinematic models of concentric tube robots have matured from considering only tube bending to considering tube twisting as well as external loading. While these models have been demonstrated to approximate actual behavior, ...

    • Biocomputing Enters its Adolescence 

      Sunyaev, Shamil R. (BioMed Central, 2005)

    • The Bioconductor channel in F1000Research 

      Huber, Wolfgang; Carey, Vincent; Davis, Sean; Hansen, Kasper Daniel; Morgan, Martin (F1000Research, 2015)
      Bioconductor ( bioconductor.org) is a rich source of software and know-how for the integrative analysis of genomic data. The Bioconductor channel in F1000Research provides a forum for task-oriented workflows that each cover ...