Browsing HMS Scholarly Articles by Title
Now showing items 1686-1705 of 17918
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Bioinformatic and Molecular Investigation of Sirt3 Expression
(BioMed Central, 2012) -
Bioinformatic Identification and Characterization of Human Endothelial Cell-Restricted Genes
(BioMed Central, 2010)Background: In this study, we used a systematic bioinformatics analysis approach to elucidate genes that exhibit an endothelial cell (EC) restricted expression pattern, and began to define their regulation, tissue distribution, ... -
Bioinformatics Analysis of the Early Inflammatory Response in a Rat Thermal Injury Model
(BioMed Central, 2007)Background: Thermal injury is among the most severe forms of trauma and its effects are both local and systemic. Response to thermal injury includes cellular protection mechanisms, inflammation, hypermetabolism, prolonged ... -
Bioinformatics and HIV Latency
(Springer US, 2015)Despite effective treatment, HIV is not completely eliminated from the infected organism because of the existence of viral reservoirs. A major reservoir consists of infected resting CD4+ T cells, mostly of memory type, ... -
A Bioinformatics Method Identifies Prominent Off-targeted Transcripts in RNAi Screens
(Nature Publishing Group, 2012)Because off-target effects hamper interpretation and validation of RNAi screens, we developed a bioinformatics method, Genome-wide Enrichment of Seed Sequence matches (GESS), to identify candidate off-targeted transcripts ... -
Bioinformatics of Recent Aqua- and Orthoreovirus Isolates from Fish: Evolutionary Gain or Loss of FAST and Fiber Proteins and Taxonomic Implications
(Public Library of Science, 2013)Family Reoviridae, subfamily Spinareovirinae, includes nine current genera. Two of these genera, Aquareovirus and Orthoreovirus, comprise members that are closely related and consistently share nine homologous proteins. ... -
Bioinformatics Workflow for Clinical Whole Genome Sequencing at Partners HealthCare Personalized Medicine
(MDPI, 2016)Effective implementation of precision medicine will be enhanced by a thorough understanding of each patient’s genetic composition to better treat his or her presenting symptoms or mitigate the onset of disease. This ideally ... -
Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation
(National Academy of Sciences, 2009)Through an immune-mediated graft-versus-leukemia effect, allogeneic hematopoietic stem cell transplantation (HSCT) affords durable clinical benefits for many patients with hematologic malignancies. Nonetheless, subjects ... -
Biologic Concentration Testing in Inflammatory Bowel Disease
(Lippincott Williams & Wilkins, 2015)Abstract: Anti-TNF medications have revolutionized the care of patients with inflammatory bowel disease. However, despite an initial robust effect, loss of response is common and long-term results are disappointing. Much ... -
Biological and Clinical Implications of Clonal Heterogeneity and Clonal Evolution in Multiple Myeloma
(2014)Clonal heterogeneity and clonal evolution have emerged as critical concepts in the field of oncology over the past four decades, largely thanks to the implementation of novel technologies such as comparative genomic ... -
Biological Code Breaking in the 21st Century
(EMBO and Nature Publishing Group, 2006) -
Biological Insights From 108 Schizophrenia-Associated Genetic Loci
(2014)Summary Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here, we ... -
Biological Knee Reconstruction With Concomitant Autologous Chondrocyte Implantation and Meniscal Allograft Transplantation: Mid- to Long-term Outcomes
(SAGE Publications, 2016)Background: Treating articular cartilage defects and meniscal deficiency is challenging. Although some short- to mid-term follow-up studies report good clinical outcomes after concurrent autologous chondrocyte implantation ... -
The Biological Response following Autogenous Bone Grafting for Large-Volume Defects of the Knee: Index Surgery through 12 to 21 Years’ Follow-up
(SAGE Publications, 2012)Objective: This report focuses on the biological events occurring at various intervals following autogenous bone grafting of large-volume defects of the knee joint’s femoral condyle secondary to osteochondritis dissecans ... -
Biological Time Series Analysis Using a Context Free Language: Applicability to Pulsatile Hormone Data
(Public Library of Science, 2014)We present a novel approach for analyzing biological time-series data using a context-free language (CFL) representation that allows the extraction and quantification of important features from the time-series. This ... -
Biological variability dominates and influences analytical variance in HPLC-ECD studies of the human plasma metabolome
(BioMed Central, 2007)Background: Biomarker-based assessments of biological samples are widespread in clinical, pre-clinical, and epidemiological investigations. We previously developed serum metabolomic profiles assessed by HPLC-separations ... -
A Biologically Constrained, Mathematical Model of Cortical Wave Propagation Preceding Seizure Termination
(Public Library of Science, 2015)Epilepsy—the condition of recurrent, unprovoked seizures—manifests in brain voltage activity with characteristic spatiotemporal patterns. These patterns include stereotyped semi-rhythmic activity produced by aggregate ... -
Biologically Informed Deep Neural Network for Prostate Cancer Discovery
(Springer Science and Business Media LLC, 2021-09-22)Determination of molecular features that mediate clinically aggressive phenotypes in prostate cancer remains a major biological and clinical challenge [1,2]. Recent advances in machine learning interpretability as applied ... -
Biology and structure of leukocyte β 2 integrins and their role in inflammation
(F1000Research, 2016)Integrins comprise a large family of αβ heterodimeric cell adhesion receptors that are expressed on all cells except red blood cells and that play essential roles in the regulation of cell growth and function. The leukocyte ... -
The Biology and Treatment of EML4-ALK Non-Small Cell Lung Cancer
(Elsevier BV, 2010-07)The fusion between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) has recently been identified in a subset of non-small cell lung cancers (NSCLCs). EML4-ALK is most often ...