Browsing HMS Scholarly Articles by Title
Now showing items 1737-1756 of 17922
-
Bioorthogonal Imaging of Aurora Kinase a in Live Cells
(Wiley, 2012) -
Bioorthogonal Small Molecule Imaging Agents Allow Single-Cell Imaging of MET
(Public Library of Science, 2013)The hepatocyte growth factor receptor (MET) is a receptor tyrosine kinase (RTK) that has emerged as an important cancer target. Consequently, a number of different inhibitors varying in specificity are currently in clinical ... -
Biophysical and Functional Characterization of Rhesus Macaque IgG Subclasses
(Frontiers Media S.A., 2016)Antibodies raised in Indian rhesus macaques [Macaca mulatta (MM)] in many preclinical vaccine studies are often evaluated in vitro for titer, antigen-recognition breadth, neutralization potency, and/or effector function, ... -
Biophysical Prediction of Protein-Peptide Interactions and Signaling Networks Using Machine Learning
(Springer Science and Business Media LLC, 2020-01-06)In mammalian cells, much of signal transduction is mediated by weak protein-protein interactions between globular peptide-binding domains (PBDs) and unstructured peptidic motifs in partner proteins. The number and diversity ... -
Biophysical properties of presynaptic short-term plasticity in hippocampal neurons: insights from electrophysiology, imaging and mechanistic models
(Frontiers Media S.A., 2014)Hippocampal neurons show different types of short-term plasticity (STP). Some exhibit facilitation of their synaptic responses and others depression. In this review we discuss presynaptic biophysical properties behind ... -
Biopsy interpretation of colonic biopsies when inflammatory bowel disease is excluded
(Springer Nature, 2012)The interpretation of colonic biopsies related to inflammatory conditions can be challenging because the colorectal mucosa has a limited repertoire of morphologic responses to various injurious agents. Only few processes ... -
Bioresponsive antisense DNA gold nanobeacons as a hybrid in vivo theranostics platform for the inhibition of cancer cells and metastasis
(Nature Publishing Group, 2015)Gold nanobeacons can be used as a powerful tool for cancer theranostics. Here, we proposed a nanomaterial platform based on gold nanobeacons to detect, target and inhibit the expression of a mutant Kras gene in an in vivo ... -
Biosocial Approaches to the 2013-2016 Ebola Pandemic
(Harvard University Press, 2016)Abstract Despite more than 25 documented outbreaks of Ebola since 1976, our understanding of the disease is limited, in particular the social, political, ecological, and economic forces that promote (or limit) its spread. ... -
A Biosurveillance-driven Home Score to Guide Strep Pharyngitis Treatment
(University of Illinois at Chicago Library, 2013)Objective: 1. To derive and validate an accurate clinical prediction model (“home score”) to estimate a patient’s risk of group A streptococcal (GAS) pharyngitis before a health care visit based only on history and real-time ... -
Bipartite Community Structure of eQTLs
(Public Library of Science, 2016)Genome Wide Association Studies (GWAS) and expression quantitative trait locus (eQTL) analyses have identified genetic associations with a wide range of human phenotypes. However, many of these variants have weak effects ... -
Bipolar disorder in the digital age: new tools for the same illness
(Springer Berlin Heidelberg, 2016)“Nothing is more difficult than to ascertain the length of time that a maniacal patient can exist without sleep.”—Dr. Sutherland (Br J Psychiatry 7(37):1–19, 1861). Dr. Sutherland’s patient was suffering from an acute manic ... -
Birdshot chorioretinopathy in a male patient with facioscapulohumeral muscular dystrophy
(Springer Berlin Heidelberg, 2015)Background: We report a case of birdshot chorioretinopathy (BSCR) in a patient with facioscapulohumeral muscular dystrophy (FSHD). A 40-year-old male with history of facioscapulohumeral muscular dystrophy with significant ... -
Birth Outcomes in a Prospective Pregnancy-Birth Cohort Study of Environmental Risk Factors in Kuwait: The TRACER Study
(Wiley-Blackwell, 2016)Background—Rapid development and westernisation in Kuwait and other Gulf states have been accompanied by rising rates of obesity, diabetes, asthma, and other chronic conditions. Prenatal experiences and exposures may be ... -
Birth weight and later life adherence to unhealthy lifestyles in predicting type 2 diabetes: prospective cohort study
(BMJ Publishing Group Ltd., 2015)Objectives To prospectively assess the joint association of birth weight and established lifestyle risk factors in adulthood with incident type 2 diabetes and to quantitatively decompose the attributing effects to birth ... -
Birth Weight for Gestational Age Norms for a Large Cohort of Infants Born to HIV-Negative Women in Botswana Compared with Norms for U.S.-Born Black Infants
(BioMed Central, 2011)Background: Standard values for birth weight by gestational age are not available for sub-Saharan Africa, but are needed to evaluate incidence and risk factors for intrauterine growth retardation in settings where HIV, ... -
Birth Weight, Genetic Susceptibility, and Adulthood Risk of Type 2 Diabetes
(American Diabetes Association, 2012)OBJECTIVE Both stressful intrauterine milieus and genetic susceptibility have been linked to later-life diabetes risk. The current study aims to examine the interaction between low birth weight, a surrogate measure of ... -
Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood
(BioMed Central, 2016)Background: Both higher and lower fetal growth are associated with cardio-metabolic health later in life, suggesting that prenatal developmental programming determines long-term cardiovascular disease risk. Epigenetic ... -
Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013
(NLM-Export, 2014)Background: In 2007, an expert panel reviewed associations between bisphenol A (BPA) exposure and reproductive health outcomes. Since then, new studies have been conducted on the impact of BPA on reproduction. Objective: ...