Browsing HMS Scholarly Articles by Title

Now showing items 1754-1773 of 17922

    • Birth Weight, Genetic Susceptibility, and Adulthood Risk of Type 2 Diabetes 

      Li, Yanping; Qi, Qibin; Workalemahu, Tsegaselassie; Hu, Frank B.; Qi, Lu (American Diabetes Association, 2012)
      OBJECTIVE Both stressful intrauterine milieus and genetic susceptibility have been linked to later-life diabetes risk. The current study aims to examine the interaction between low birth weight, a surrogate measure of ...

    • Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood 

      Agha, Golareh; Hajj, Hanine; Rifas-Shiman, Sheryl L.; Just, Allan C.; Hivert, Marie-France; Burris, Heather H.; Lin, Xihong; Litonjua, Augusto A.; Oken, Emily; DeMeo, Dawn L.; Gillman, Matthew W.; Baccarelli, Andrea A. (BioMed Central, 2016)
      Background: Both higher and lower fetal growth are associated with cardio-metabolic health later in life, suggesting that prenatal developmental programming determines long-term cardiovascular disease risk. Epigenetic ...

    • Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013 

      Peretz, Jackye; Vrooman, Lisa; Ricke, William A.; Hunt, Patricia A.; Ehrlich, Shelley; Hauser, Russ; Padmanabhan, Vasantha; Taylor, Hugh S.; Swan, Shanna H.; VandeVoort, Catherine A.; Flaws, Jodi A. (NLM-Export, 2014)
      Background: In 2007, an expert panel reviewed associations between bisphenol A (BPA) exposure and reproductive health outcomes. Since then, new studies have been conducted on the impact of BPA on reproduction. Objective: ...

    • Bisphosphonate Prescribing, Persistence and Cumulative Exposure in Ontario, Canada 

      Burden, A. M.; Paterson, J. M.; Solomon, Daniel Hal; Mamdani, M.; Juurlink, D. N.; Cadarette, S. M. (Springer-Verlag, 2012)
      Summary: We studied new users of oral bisphosphonates and found that less than half persisted with therapy for 2 years, and interruptions in use were common. During a median observation period of 4.7 years, 10% of patients ...

    • Bisphosphonates and Risk of Cardiovascular Events: A Meta-Analysis 

      Kim, Dae Hyun; Rogers, James R.; Fulchino, Lisa A.; Kim, Caroline A.; Solomon, Daniel H.; Kim, Seoyoung C. (Public Library of Science, 2015)
      Background and Objectives Some evidence suggests that bisphosphonates may reduce atherosclerosis, while concerns have been raised about atrial fibrillation. We conducted a meta-analysis to determine the effects of ...

    • Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation 

      Ligthart, Symen; Vaez, Ahmad; Hsu, Yi-Hsiang; Stolk, Ronald; Uitterlinden, André G.; Hofman, Albert; Alizadeh, Behrooz Z.; Franco, Oscar H.; Dehghan, Abbas (BioMed Central, 2016)
      Background: Genome-wide association studies (GWAS) have identified multiple genetic loci for C-reactive protein (CRP) and lipids, of which some overlap. We aimed to identify genetic pleiotropy among CRP and lipids in order ...

    • BKM-120 (Buparlisib): A Phosphatidyl-Inositol-3 Kinase Inhibitor with Anti-Invasive Properties in Glioblastoma 

      Speranza, Maria-Carmela; Nowicki, Michal O.; Behera, Prajna; Cho, Choi-Fong; Chiocca, E. Antonio; Lawler, Sean E. (Nature Publishing Group, 2016)
      Glioblastoma is an aggressive, invasive tumor of the central nervous system (CNS). There is a widely acknowledged need for anti-invasive therapeutics to limit glioblastoma invasion. BKM-120 is a CNS-penetrant pan-class I ...

    • BL-8040, a CXCR4 Antagonist, in Combination with Pembrolizumab and Chemotherapy for Pancreatic Cancer: the COMBAT trial 

      Bockorny, Bruno; Wolpin, Brian
      Single agent immunotherapy has limited effect in pancreatic ductal adenocarcinoma (PDAC), underscoring the need to co-target alternative pathways. CXCR4 blockade promotes T-cell tumor infiltration and is synergistic with ...

    • Black Carbon Exposure, Oxidative Stress Genes, and Blood Pressure in a Repeated-measures Study 

      Mordukhovich, Irina; Wilker, Elissa Hope; Suh MacIntosh, Helen H.; Wright, Robert O.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2009)
      Background: Particulate matter (PM) air pollution has been associated with cardiovascular morbidity and mortality, and elevated blood pressure (BP) is a known risk factor for cardiovascular disease. A small number of studies ...

    • Black Carbon Exposures, Blood Pressure, and Interactions with Single Nucleotide Polymorphisms in MicroRNA Processing Genes 

      Wilker, Elissa Hope; Baccarelli, Andrea; Suh MacIntosh, Helen H.; Vokonas, Pantel S; Wright, Robert O.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2010)
      Background: Black carbon (BC) is a marker of traffic pollution that has been associated with blood pressure (BP), but findings have been inconsistent. MicroRNAs (miRNAs) are emerging as key regulators of gene expression, ...

    • Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax 

      Montero, Joan; Stephansky, Jason; Cai, Tianyu; Griffin, Gabriel Kenneth; Cabal-Hierro, Lucia; Togami, Katsuhiro; Hogdal, Leah J.; Galinsky, Ilene; Morgan, Elizabeth Amy; Aster, Jon Christopher; Davids, Matthew Steven; Leboeuf, Nicole Renee; Stone, Richard Maury; Konopleva, Marina; Pemmaraju, Naveen; Letai, Anthony George; Lane, Andrew Alan (American Association for Cancer Research (AACR), 2016)
      Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematologic malignancy with dismal outcomes for which no standard therapy exists. We found that primary BPDCN cells were dependent on the anti-apoptotic ...

    • Blending Aboriginal and Western healing methods to treat intergenerational trauma with substance use disorder in Aboriginal peoples who live in Northeastern Ontario, Canada 

      Marsh, Teresa Naseba; Coholic, Diana; Cote-Meek, Sheila; Najavits, Lisa M (BioMed Central, 2015)
      As with many Indigenous groups around the world, Aboriginal communities in Canada face significant challenges with trauma and substance use. The complexity of symptoms that accompany intergenerational trauma and substance ...

    • Bleomycin and IL-1β–mediated Pulmonary Fibrosis is IL-17A Dependent 

      Wilson, Mark S.; Madala, Satish K.; Ramalingam, Thirumalai R.; Gochuico, Bernadette R.; Rosas, Ivan O.; Cheever, Allen W.; Wynn, Thomas A. (The Rockefeller University Press, 2010)
      Idiopathic pulmonary fibrosis (IPF) is a destructive inflammatory disease with limited therapeutic options. To better understand the inflammatory responses that precede and concur with collagen deposition, we used three ...

    • Blink patterns and lid-contact times in dry-eye and normal subjects 

      Ousler, George W; Abelson, Mark B; Johnston, Patrick R; Rodriguez, John; Lane, Keith; Smith, Lisa M (Dove Medical Press, 2014)
      Purpose To classify blinks in dry eye and normal subjects into six subtypes, and to define the blink rate and duration within each type of blink, as well as the total lid-contact time/minute. Materials and methods This was ...

    • The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells 

      Zhang, Haojian; Peng, Cong; Hu, Yiguo; Li, Huawei; Sheng, Zhi; Chen, Yaoyu; Sullivan, Con; Cerny, Jan; Hutchinson, Lloyd; Higgins, Anne; Miron, Patricia; Zhang, Xueqing; Brehm, Michael; Li, Dongguang; Green, Michael R.; Li, Shaoguang (2012)
      A therapeutic strategy for treating cancer is to target and eradicate cancer stem cells (CSCs) without harming their normal stem cell counterparts. The success of this approach relies on identification of molecular pathways ...

    • Blm10 Protein Promotes Proteasomal Substrate Turnover by an Active Gating Mechanism 

      Dange, Thomas; Smith, David; Noy, Tahel; Rommel, Philipp C.; Jurzitza, Lukas; Cordero, Radames B.; Legendre, Anne; Finley, Daniel; Goldberg, Alfred L.; Schmidt, Marion (American Society for Biochemistry and Molecular Biology, 2011)
      Background: Association of the proteasome core with activators regulates proteasome activity. Results: Blm10 association increases proteasome activity toward peptides and the unstructured proteasome substrate tau-441. This ...

    • Block matching 3D random noise filtering for absorption optical projection tomography 

      Feruglio, P. Fumene; Vinegoni, C.; Gros, J.; Sbarbati, A.; Weissleder, R. (IOP Publishing, 2010)
      Absorption and emission optical projection tomography (OPT), alternatively referred to as optical computed tomography (optical-CT) and optical-emission computed tomography (optical-ECT), are recently developed three-dimensional ...

    • Blockade of CD40-CD154 Costimulatory Pathway Promotes Survival of Allogeneic Corneal Transplants 

      Qian, Ying; Boisgerault, Florence; Benichou, Gilles A.; Dana, Reza (Association for Research in Vision and Ophthalmology, 2001)
      purpose. To determine the effect of systemic anti-CD154 monoclonal antibody on the survival of orthotopic murine corneal transplants. methods. BALB/c mice were used as recipients of syngeneic, multiple minor histocompatability ...

    • Blockade of Glioma Proliferation through Allosteric Inhibition of JAK2 

      He, Kunyan; Qi, Qi; Chan, Chi-Bun; Xiao, Ge; Liu, Xia; Tucker-Burden, Carol; Wang, Liya; Mao, Hui; Lu, Xiang; McDonald, Frank E.; Luo, Hongbo; Fan, Qi-Wen; Weiss, William A.; Sun, Shi-Yong; Brat, Daniel J.; Ye, Keqiang (American Association for the Advancement of Science (AAAS), 2013)
      The gene that encodes the epidermal growth factor receptor (EGFR) is frequently overexpressed or mutated in human cancers, including glioblastoma. However, the efficacy of EGFR-targeted small-molecule inhibitors or monoclonal ...

    • Blockade of Prolymphangiogenic Vascular Endothelial Growth Factor C in Dry Eye Disease 

      Goyal, Sunali; Chauhan, Sunil Kumar; Dana, Reza (American Medical Association (AMA), 2012)
      Objective To determine if blocking prolymphangiogenic factors like VEGF-C would suppress alloimmunity in dry eye disease (DED) using a murine model. Methods The effects of intraperitoneal injections of 400 μg of ...