Browsing HMS Scholarly Articles by Title

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    • Blood, Guts, and Hope 

      Schoellhammer, Carl; Langer, Robert S.; Traverso, Carlo Giovanni (Sigma Xi, 2017)
      Treatment of gastrointestinal tissue with ultrasound makes it more permeable to medications that can alleviate inflammatory bowel disease.

    • Blood-Based Biomarkers of Aggressive Prostate Cancer 

      Liong, Men Long; Lim, Chun Ren; Yang, Hengxuan; Chao, Samuel; Bong, Chin Wei; Leong, Wing Seng; Das, Prashanta Kumar; Loh, Chit Sin; Lau, Ban Eng; Yu, Choon Geok; Ooi, Edie Jian Jiek; Nam, Robert K.; Allen, Paul Denney; Steele, Graeme S.; Wassmann, Karl; Richie, Jerome Paul; Liew, Choong Chin (Public Library of Science, 2012)
      Purpose: Prostate cancer is a bimodal disease with aggressive and indolent forms. Current prostate-specific-antigen testing and digital rectal examination screening provide ambiguous results leading to both under-and ...

    • Blood-Brain Barrier Integrity and Breast Cancer Metastasis to the Brain 

      Arshad, Farheen; Sy, Christopher; Wang, Lili; Avraham, Shalom; Avraham, Hava Karsenty (SAGE-Hindawi Access to Research, 2010)
      Brain metastasis, an important cause of cancer morbidity and mortality, occurs in at least 30% of patients with breast cancer. A key event of brain metastasis is the migration of cancer cells through the blood-brain barrier ...

    • Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders 

      Fiorentino, Maria; Sapone, Anna; Senger, Stefania; Camhi, Stephanie S.; Kadzielski, Sarah M.; Buie, Timothy M.; Kelly, Deanna L.; Cascella, Nicola; Fasano, Alessio (BioMed Central, 2016)
      Background: Autism spectrum disorders (ASD) are complex conditions whose pathogenesis may be attributed to gene–environment interactions. There are no definitive mechanisms explaining how environmental triggers can lead ...

    • Blue Dye and Red Light, a Dynamic Combination for Prophylaxis and Treatment of Cutaneous Candida albicans Infections in Mice 

      Dai, Tianhong; Arce, Vida de; Tegos, George P.; Hamblin, Michael R. (American Society for Microbiology, 2011)
      The objective of this study was to investigate photodynamic therapy (PDT), using blue dye and red light, for prophylaxis and treatment of cutaneous Candida albicans infections in mice. A mouse model of skin abrasion infected ...

    • Blunted Response to Combination Antiretroviral Therapy in HIV Elite Controllers: An International HIV Controller Collaboration 

      Boufassa, Faroudy; Lechenadec, Jérome; Meyer, Laurence; Costagliola, Dominique; Hunt, Peter W.; Pereyra, Florencia; Deeks, Steve; Pancino, Gianfranco; Taulera, Olivier; Lichterfeld, Mathias; Delobel, Pierre; Saez-Cirion, Asier; Lambotte, Olivier (Public Library of Science, 2014)
      Objective: HIV “elite controllers” (ECs) spontaneously control viral load, but some eventually require combination antiretroviral treatment (cART), due to a loss of viral control or a decline in CD4 T-cell counts. Here we ...

    • BMP Signaling Is Required for Controlling Somatic Stem Cell Self-Renewal in the Drosophila Ovary 

      Kirilly, Daniel; Spana, Eric P.; Perrimon, Norbert; Padgett, Richard W.; Xie, Ting (Elsevier (Cell Press), 2005)

    • BMP signaling modulation attenuates cerebral arteriovenous malformation formation in a vertebrate model 

      Walcott, Brian P (Nature Publishing Group, 2014)
      Cerebral arteriovenous malformations (AVMs) are vascular anomalies that carry a high risk of stroke and death. To test potential AVM therapies, a reverse genetics approach was used to model AVMs in zebrafish. Antisense ...

    • BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway 

      Kamiya, Nobuhiro; Ye, Ling; Kobayashi, Tatsuya; Mochida, Yoshiyuki; Yamauchi, Mitsuo; Kronenberg, Henry M.; Feng, Jian Q.; Mishina, Yuji (Company of Biologists, 2008)
      Bone morphogenetic proteins (BMPs) are known to induce ectopic bone. However, it is largely unknown how BMP signaling in osteoblasts directly regulates endogenous bone. This study investigated the mechanism by which BMP ...

    • BMP signaling stimulates cellular differentiation at multiple steps during cartilage development 

      Kobayashi, Tatsuya; Lyons, Karen M.; McMahon, Andrew P.; Kronenberg, Henry M. (National Academy of Sciences, 2005)
      Bone morphogenetic proteins (BMPs) play important roles at multiple stages of endochondral bone formation. However, the roles of BMP signaling in chondrocytes in vivo are still contentious. In the present study, we ...

    • BMP4 Signaling is Involved in the Generation of Inner Ear Sensory Epithelia 

      Li, Huawei; Corrales, Carleton E; Wang, Zhengmin; Zhao, Yanling; Wang, Yucheng; Heller, Stefan; Liu, Hong (BioMed Central, 2005)
      Background: The robust expression of BMP4 in the incipient sensory organs of the inner ear suggests possible roles for this signaling protein during induction and development of auditory and vestibular sensory epithelia. ...

    • Bmp7 Maintains Undifferentiated Kidney Progenitor Population and Determines Nephron Numbers at Birth 

      Tomita, Mayumi; Asada, Misako; Asada, Nariaki; Nakamura, Jin; Oguchi, Akiko; Higashi, Atsuko Y.; Endo, Shuichiro; Robertson, Elizabeth; Kimura, Takeshi; Kita, Toru; Economides, Aris N.; Kreidberg, Jordan; Yanagita, Motoko (Public Library of Science, 2013)
      The number of nephrons, the functional units of the kidney, varies among individuals. A low nephron number at birth is associated with a risk of hypertension and the progression of renal insufficiency. The molecular ...

    • BMS1 Is Mutated in Aplasia Cutis Congenita 

      Marneros, Alexander G. (Public Library of Science, 2013)
      Aplasia cutis congenita (ACC) manifests with localized skin defects at birth of unknown cause, mostly affecting the scalp vertex. Here, genome-wide linkage analysis and exome sequencing was used to identify the causative ...

    • The BODECOST Index (BCI): a composite index for assessing the impact of COPD in real life 

      Dal Negro, Roberto W.; Celli, Bartolome R. (BioMed Central, 2016)
      Background: Chronic Obstructive Pulmonary Disease (COPD) is a progressive condition which is characterized by a dramatic socio-economic impact. Several indices were extensively investigated in order to asses the mortality ...

    • Body esteem in adolescent hair pullers 

      ALTENBURGER, ERIN M.; TUNG, ESTHER S.; KEUTHEN, NANCY J. (Akadémiai Kiadó, 2014)
      Background and aims: Trichotillomania (TTM) often first presents in adolescence, a developmental period marked by vulnerability in body image. To date, no one has studied the relationship between this disorder and body ...

    • Body expressions of emotion do not trigger fear contagion in autism spectrum disorder 

      Hadjikhani, Nouchine; Joseph, Robert M.; Manoach, Dara S.; Naik, Paulami; Snyder, Josh; Dominick, Kelli; Hoge, Rick; Stock, Jan den; Flusberg, Helen Tager; Gelder, Beatrice de (Oxford University Press, 2009)
      Although there is evidence of emotion perception deficits in autism spectrum disorder (ASD), research on this topic has been mostly confined to perception of emotions in faces. Using behavioral measures and 3T functional ...

    • Body Fat Percentage Should Not Be Confused With Lifestyle Behaviors 

      Kyle, Theodore K.; Stanford, Fatima Cody (Elsevier BV, 2016)

    • Body Mass Index and Decline of Cognitive Function 

      Kim, Sujin; Kim, Yongjoo; Park, Sang Min (Public Library of Science, 2016)
      Background: The association between body mass index (BMI) and cognitive function is a public health issue. This study investigated the relationship between obesity and cognitive impairment which was assessed by the Korean ...

    • Body Mass Index Genetic Risk Score and Endometrial Cancer Risk 

      Prescott, Jennifer; Setiawan, Veronica W.; Wentzensen, Nicolas; Schumacher, Fredrick; Yu, Herbert; Delahanty, Ryan; Bernstein, Leslie; Chanock, Stephen J.; Chen, Chu; Cook, Linda S.; Friedenreich, Christine; Garcia-Closas, Monserrat; Haiman, Christopher A.; Le Marchand, Loic; Liang, Xiaolin; Lissowska, Jolanta; Lu, Lingeng; Magliocco, Anthony M.; Olson, Sara H.; Risch, Harvey A.; Shu, Xiao-Ou; Ursin, Giske; Yang, Hannah P.; Kraft, Peter; De Vivo, Immaculata (Public Library of Science, 2015)
      Genome-wide association studies (GWAS) have identified common variants that predispose individuals to a higher body mass index (BMI), an independent risk factor for endometrial cancer. Composite genotype risk scores (GRS) ...

    • Body Mass Index, Smoking and Hypertensive Disorders during Pregnancy: A Population Based Case-Control Study 

      Gudnadóttir, Thuridur A.; Bateman, Brian T.; Hernádez-Díaz, Sonia; Luque-Fernandez, Miguel Angel; Valdimarsdottir, Unnur; Zoega, Helga (Public Library of Science, 2016)
      While obesity is an indicated risk factor for hypertensive disorders of pregnancy, smoking during pregnancy has been shown to be inversely associated with the development of preeclampsia and gestational hypertension. The ...