Now showing items 189-208 of 17918

    • Abnormal movements in critical care patients with brain injury: a diagnostic approach 

      Hannawi, Yousef; Abers, Michael S.; Geocadin, Romergryko G.; Mirski, Marek A. (BioMed Central, 2016)
      Abnormal movements are frequently encountered in patients with brain injury hospitalized in intensive care units (ICUs), yet characterization of these movements and their underlying pathophysiology is difficult due to the ...
    • Abnormal Neural Synchrony in Schizophrenia 

      Spencer, Kevin M.; Nestor, Paul Gerard; Niznikiewicz, Margaret A.; Salisbury, Dean F.; Shenton, Martha Elizabeth; McCarley, Robert William (2003)
      Schizophrenia has been conceptualized as a failure of cognitive integration, and abnormalities in neural circuitry (particularly inhibitory interneurons) have been proposed as a basis for this disorder. We used measures ...
    • Abnormal pitch mismatch negativity in individuals with schizotypal personality disorder 

      Niznikiewicz, Margaret A.; Spencer, Kevin M.; Dickey, Chandlee C.; Voglmaier, Martina M.; Seidman, Larry Joel; Shenton, Martha Elizabeth; McCarley, Robert William (Elsevier BV, 2009)
      Background: The goal of the study was to examine mismatch negativity (MMN) in schizotypal personality disorder (SPD) individuals. Abnormal MMN has been a consistent finding in chronic schizophrenia and there are also have ...
    • Abnormal rib count in scoliosis surgery: impact on the reporting of spinal fusion levels 

      Spencer, Hillard T.; Gold, Meryl E.; Hresko, M. Timothy (Springer Berlin Heidelberg, 2014)
      Purpose Variation in rib numbering has been noted in adolescent idiopathic scoliosis (AIS), but its effect on the reporting of fusion levels has not been studied. We hypothesized that vertebral numbering variations can ...
    • Abnormal Striatal Dopamine Transmission in Schizophrenia 

      Brunelin, Jerome; Fecteau, Shirley; Suaud-Chagny, Marie-Françoise (Bentham Science Publishers, 2013)
      Despite numerous revisions and reformulations, dopamine (DA) hypothesis of schizophrenia remains a pivotal neurochemical hypothesis of this illness. The aim of this review is to expose and discuss findings from positron ...
    • Abnormal white matter microstructure and increased extracellular free-water in the cingulum bundle associated with delusions in chronic schizophrenia 

      Oestreich, Lena K.L.; Pasternak, Ofer; Shenton, Martha E.; Kubicki, Marek; Gong, Xue; McCarthy-Jones, Simon; Whitford, Thomas J. (Elsevier, 2016)
      Background: There is growing evidence to suggest that delusions associated with schizophrenia arise from altered structural brain connectivity. The present study investigated whether structural changes in three major ...
    • Abnormalities in personal space and parietal–frontal function in schizophrenia 

      Holt, Daphne J.; Boeke, Emily A.; Coombs, Garth; DeCross, Stephanie N.; Cassidy, Brittany S.; Stufflebeam, Steven; Rauch, Scott L.; Tootell, Roger B.H. (Elsevier, 2015)
      Schizophrenia is associated with subtle abnormalities in day-to-day social behaviors, including a tendency in some patients to “keep their distance” from others in physical space. The neural basis of this abnormality, and ...
    • Abnormalities of middle longitudinal fascicle and disorganization in patients with schizophrenia 

      Asami, Takeshi; Saito, Yukiko; Whitford, Thomas; Makris, Nikos; Niznikiewicz, Margaret A.; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Elsevier BV, 2013)
      Introduction—The Middle Longitudinal Fascicle (MdLF) is a long association fiber connecting the superior temporal gyrus (STG) and temporal pole with the angular gyrus through the white matter of the STG, structures which ...
    • Abnormalities of the Left Temporal Lobe and Thought Disorder in Schizophrenia 

      Shenton, Martha Elizabeth; Kikinis, Ron; Jolesz, Ferenc A.; Pollak, Seth D.; Lemay, Marjorie Jeannette; Wible, Cynthia Gayle; Hokama, Hiroto; Martin, John; Metcalf, Dave; Coleman, Michael James; McCarley, Robert William (New England Journal of Medicine (NEJM/MMS), 1992)
      BACKGROUND: Data from postmortem, CT, and magnetic resonance imaging (MRI) studies indicate that patients with schizophrenia may have anatomical abnormalities of the left temporal lobe, but it is unclear whether these ...
    • ABO blood group and incidence of epithelial ovarian cancer 

      Gates, Margaret A.; Wolpin, Brian M.; Cramer, Daniel William; Hankinson, Susan Elizabeth; Tworoger, Shelley Slate (Wiley-Blackwell, 2010)
      Previous studies have observed an association between ABO blood group and risk of certain malignancies, including ovarian cancer; however, no prospective studies of the association with ovarian cancer risk are available. ...
    • ABO Blood Group and Incidence of Skin Cancer 

      Xie, Jing; Qureshi, Abrar A.; Li, Yunhui; Han, Jiali (Public Library of Science, 2010)
      Background: Previous studies have examined the association between ABO blood group and the risk of some malignancies. However, no prospective cohort study to date has examined the association between ABO blood group and ...
    • ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium 

      Poole, Elizabeth M.; Gates, Margaret A.; High, Brigit A.; Chanock, Stephen J.; Cramer, Daniel William; Cunningham, Julie M.; Fridley, Brooke L.; Gayther, Simon A.; Goode, Ellen L.; Iversen, Edwin S.; Lissowska, Jolanta; Weber, Rachel T. Palmieri; Pharoah, Paul D. P.; Phelan, Catherine M.; Ramus, Susan J.; Schildkraut, Joellen M.; Sutphen, Rebecca; Tsai, Ya-Yu; Tyrer, Jonathan; Vierkant, Robert A.; Wentzensen, Nicolas; Yang, Hannah P.; Terry, Kathryn Lynne; Tworoger, Shelley Slate (Springer Science + Business Media, 2012)
      Purpose Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. Methods In 8 studies participating in the Ovarian Cancer Association Consortium ...
    • Abolition of Cyclin-Dependent Kinase Inhibitor p16Ink4a and p21Cip1/Waf1 Functions Permits Ras-Induced Anchorage-Independent Growth in Telomerase-Immortalized Human Fibroblasts 

      Wei, Wenyi; Jobling, Wendy A.; Chen, Wen; Hahn, William C.; Sedivy, John M. (American Society for Microbiology, 2003)
      Human cells are more resistant to both immortalization and malignant transformation than rodent cells. Recent studies have established the basic genetic requirements for the transformation of human cells, but much of this ...
    • Abrogated Thioredoxin System Causes Increased Sensitivity to TNF-α-Induced Apoptosis via Enrichment of p-ERK 1/2 in the Nucleus 

      Yoo, Min-Hyuk; Carlson, Bradley A.; Gladyshev, Vadim N.; Hatfield, Dolph L. (Public Library of Science, 2013)
      Thioredoxin (Trx) and thioredoxin reductase 1 (TR1) are among the major redox regulators in mammalian cells and have a wide variety of roles, including removal of intracellular reactive oxygen species (ROS) and prevention ...
    • Abrogation of Antibody-Induced Arthritis in Mice by a Self-Activating Viridin Prodrug and Association with Impaired Neutrophil and Endothelial Cell Function 

      Stangenberg, Lars; Ellson, Chris; Cortez-Retamozo, Virna; Ortiz-Lopez, Adriana; Yuan, Hushan; Blois, Joseph; Smith, Ralph A.; Yaffe, Michael B.; Weissleder, Ralph; Benoist, Christophe; Mathis, Diane; Josephson, Lee; Mahmood, Umar (Wiley, 2009)
      Objective. To test a novel self-activating viridin (SAV) prodrug that slowly releases wortmannin, a potent phosphoinositide 3-kinase inhibitor, in a model of antibody-mediated inflammatory arthritis.Methods. The SAV prodrug ...
    • Absence of Dopaminergic Neuronal Degeneration and Oxidative Damage in Aged DJ-1-deficient Mice 

      Yamaguchi, Hiroo; Shen, Jie (BioMed Central, 2007)
      Parkinson's disease is the most common movement disorder characterized by dopaminergic dysfunction and degeneration. Loss-of-function mutations in the DJ-1 gene have been linked to autosomal recessive forms of early-onset ...
    • The Absence of Obstructive Sleep Apnea May Protect against Non-Alcoholic Fatty Liver in Patients Undergoing Bariatric Surgery 

      Corey, Kathleen Elizabeth; Misdraji, Joseph; Zheng, Zheng; Malecki, Kyle M.; Kneeman, Jacob; Gelrud, Louis; Chung, Raymond Taeyong (Public Library of Science, 2013)
      Background: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide and its progressive form, steatohepatitis, will be the leading indication for liver transplant by 2020. While risk ...
    • Absence of Replication of Porcine Endogenous Retrovirus and Porcine Lymphotropic Herpesvirus Type 1 with Prolonged Pig Cell Microchimerism after Pig-to-Baboon Xenotransplantation 

      Issa, Nicolas Chafic; Wilkinson, R. A.; Griesemer, Adam; Cooper, David K. C.; Yamada, Kazuhiko; Sachs, David H.; Fishman, Jay Alan (American Society for Microbiology, 2008)
      Porcine endogenous retrovirus (PERV), porcine cytomegalovirus (PCMV), and porcine lymphotropic her- pesvirus (PLHV) are common porcine viruses that may be activated with immunosuppression for xenotrans- plantation. Studies ...
    • Absolute Enrichment: Gene Set Enrichment Analysis for Homeostatic Systems 

      Saxena, Vishal; Orgill, Dennis Paul; Kohane, Isaac Samuel (Oxford University Press, 2006)
      The Gene Set Enrichment Analysis (GSEA) identifies sets of genes that are differentially regulated in one direction. Many homeostatic systems will include one limb that is upregulated in response to a downregulation of ...
    • Absolute quantification of somatic DNA alterations in human cancer 

      Carter, Scott L.; Cibulskis, Kristian; Helman, Elena; McKenna, Aaron; Shen, Hui; Zack, Travis; Laird, Peter W.; Onofrio, Robert C.; Winckler, Wendy; Weir, Barbara A.; Beroukhim, Rameen; Pellman, David; Levine, Douglas A.; Lander, Eric S.; Meyerson, Matthew; Getz, Gad (2015)
      We developed a computational method (ABSOLUTE) that infers tumor purity and malignant cell ploidy directly from analysis of somatic DNA alterations. ABSOLUTE can detect subclonal heterogeneity, somatic homozygosity, and ...