Browsing HMS Scholarly Articles by Title
Now showing items 2018-2037 of 17922
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The calcium-dependent ribonuclease XendoU promotes ER network formation through local RNA degradation
(The Rockefeller University Press, 2014)How cells shape and remodel organelles in response to cellular signals is a poorly understood process. Using Xenopus laevis egg extract, we found that increases in cytosolic calcium lead to the activation of an endogenous ... -
The Calcium-Sensing Receptor Mediates Bone Turnover Induced by Dietary Calcium and Parathyroid Hormone in Neonates
(Wiley Subscription Services, Inc., A Wiley Company, 2011)We have investigated, in neonates, whether the calcium-sensing receptor (CaR) mediates the effects of dietary calcium on bone turnover and/or modulates parathyroid hormone (PTH)–induced bone turnover. Wild-type (WT) pups ... -
Calculating the Return on Investment of Mobile Healthcare
(BioMed Central, 2009)Background: Mobile health clinics provide an alternative portal into the healthcare system for the medically disenfranchised, that is, people who are underinsured, uninsured or who are otherwise outside of mainstream ... -
Calibrating physical activity intensity for hip-worn accelerometry in women age 60 to 91 years: The Women's Health Initiative OPACH Calibration Study
(2015)Objective: We conducted a laboratory-based calibration study to determine relevant cutpoints for a hip-worn accelerometer among women ≥60 years, considering both type and filtering of counts. Methods: Two hundred women ... -
Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes
(Public Library of Science, 2015)The human mutation rate is an essential parameter for studying the evolution of our species, interpreting present-day genetic variation, and understanding the incidence of genetic disease. Nevertheless, our current estimates ... -
Calibration and Validation of an Innovative Approach for Estimating General Cognitive Performance
(S. Karger AG, 2014)Objective: To evaluate a new approach for creating a composite measure of cognitive function, we calibrated a measure of general cognitive performance from existing neuropsychological batteries. Methods: We applied our ... -
A Call for Better Opioid Prescribing Training and Education
(Department of Emergency Medicine, University of California, Irvine School of Medicine, 2016)Pain is the most common complaint in the emergency department (ED), and emergency physicians face unique challenges in making opioid-related treatment decisions. Medical students and residents experience significant variation ... -
A call for comparative effectiveness research to learn whether routine clinical care decisions can protect from dementia and cognitive decline
(BioMed Central, 2016)Common diseases like diabetes, hypertension, and atrial fibrillation are probable risk factors for dementia, suggesting that their treatments may influence the risk and rate of cognitive and functional decline. Moreover, ... -
A call for transparency in tracking student and postdoc career outcomes
(The American Society for Cell Biology, 2015)There is a common misconception that the United States is suffering from a “STEM shortage,” a dearth of graduates with scientific, technological, engineering, and mathematical backgrounds. In biomedical science, however, ... -
Caloric vestibular stimulation in aphasic syndrome
(Frontiers Media S.A., 2013)Caloric vestibular stimulation (CVS) is commonly used to diagnose brainstem disorder but its therapeutic application is much less established. Based on the finding that CVS increases blood flow to brain structures associated ... -
Calyculin A-induced Vimentin Phosphorylation Sequesters 14-3-3 and Displaces Other 14-3-3 Partners in Vivo
(American Society for Biochemistry and Molecular Biology, 2000)14-3-3 proteins bind their targets through a specific serine/threonine-phosphorylated motif present on the target protein. This binding is a crucial step in the phosphorylation-dependent regulation of various key proteins ... -
The CAM-S: Development and Validation of a New Scoring System for Delirium Severity in 2 Cohorts
(American College of Physicians, 2014) -
Cambogin is Preferentially Cytotoxic to Cells Expressing PDGFR
(Public Library of Science, 2011)Platelet-derived growth factor receptors (PDGFRs) have been implicated in a wide array of human malignancies, including medulloblastoma (MB), the most common brain tumor of childhood. Although significant progress in MB ... -
“cAMP Sponge”: A Buffer for Cyclic Adenosine 3′, 5′-Monophosphate
(Public Library of Science, 2009)Background: While intracellular buffers are widely used to study calcium signaling, no such tool exists for the other major second messenger, cyclic AMP (cAMP). Methods/Principal Findings: Here we describe a genetically ... -
Can Acupuncture Treatment Be Double-Blinded? An Evaluation of Double-Blind Acupuncture Treatment of Postoperative Pain
(Public Library of Science, 2015)Blinding protects against bias but the success of blinding is seldom assessed and reported in clinical trials including studies of acupuncture where blinding represents a major challenge. Recently, needles with the potential ... -
Can apparent resting state connectivity arise from systemic fluctuations?
(Frontiers Media S.A., 2015)It is widely accepted that the fluctuations in resting state blood oxygenation level dependent (BOLD) functional MRI (fMRI) reflect baseline neuronal activation through neurovascular coupling; this data is used to infer ... -
Can biowarfare agents be defeated with light?
(Landes Bioscience, 2013)Biological warfare and bioterrorism is an unpleasant fact of 21st century life. Highly infectious and profoundly virulent diseases may be caused in combat personnel or in civilian populations by the appropriate dissemination ... -
Can enriching emotional intelligence improve medical students’ proactivity and adaptability during OB/GYN clerkships?
(IJME, 2015)Objectives: The purpose of this pilot study was to examine our hypothesis that enriching workplace emotional intelligence through resident coaches could improve third-year medical students’ adaptability and proactivity on ... -
Can Focused Trauma Education Initiatives Reduce Mortality or Improve Resource Utilization in a Low-Resource Setting?
(Springer Nature, 2014)BACKGROUND: Over 90% of injury deaths occur in low-income countries. Evaluating the impact of focused trauma courses in these settings is challenging. We hypothesized that implementation of a focused trauma education ...