Browsing HMS Scholarly Articles by Title
Now showing items 2077-2096 of 17922
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Carbon Monoxide: Present and Future Indications for a Medical Gas
(The Korean Association of Internal Medicine, 2013)Gaseous molecules continue to hold new promise in molecular medicine as experimental and clinical therapeutics. The low molecular weight gas carbon monoxide (CO), and similar gaseous molecules (e.g., \(H_2S\), nitric oxide) ... -
Carbon-Nanotube Optoacoustic Lens for Focused Ultrasound Generation and High-Precision Targeted Therapy
(Nature Publishing Group, 2012)We demonstrate a new optical approach to generate high-frequency (>15 MHz) and high-amplitude focused ultrasound, which can be used for non-invasive ultrasound therapy. A nano-composite film of carbon nanotubes (CNTs) and ... -
Carboplatin-Induced Gene Expression Changes In Vitro are Prognostic of Survival in Epithelial Ovarian Cancer
(BioMed Central, 2008)Background: We performed a time-course microarray experiment to define the transcriptional response to carboplatin in vitro, and to correlate this with clinical outcome in epithelial ovarian cancer (EOC). RNA was isolated ... -
Carboxamide SIRT1 Inhibitors Block DBC1 Binding via an Acetylation-Independent Mechanism
(Landes Bioscience, 2013)SIRT1 is an NAD+-dependent deacetylase that counteracts multiple disease states associated with aging and may underlie some of the health benefits of calorie restriction. Understanding how SIRT1 is regulated in vivo could ... -
Carboxyl-Proximal Regions of Reovirus Nonstructural Protein μNS Necessary and Sufficient for Forming Factory-Like Inclusions
(American Society for Microbiology, 2005)Mammalian orthoreoviruses are believed to replicate in distinctive, cytoplasmic inclusion bodies, commonly called viral factories or viroplasms. The viral nonstructural protein mu NS has been implicated in forming the ... -
Carboxyl-terminal Vesicular Stomatitis Virus G Protein-tagged Intestinal Na-dependent Glucose Cotransporter (sglt1). Maintenance of Surface Expression and Global Transport Function with Selective Perturbation of Transport Kinetics and Polarized Expression
(American Society for Biochemistry and Molecular Biology, 1996) -
Carboxymethylated Polyvinyl Alcohol Stabilizes Doped Ferrofluids for Biological Applications
(Wiley, 2010)Highly magnetic MnFe2O4 nanocrystals (NCs) are coated with non-cross-linked carboxymethyl polyvinyl alcohol to produce conjugates that are highly stable under varying temperatures, pH, and ionic strengths. The polymer-coated ... -
Carcinoma and Multiple Lymphomas in One Patient: Establishing the Diagnoses and Analyzing Risk Factors
(Springer-Verlag, 2009)Multiple malignancies may occur in the same patient, and a few reports describe cases with multiple hematologic and non-hematologic neoplasms. We report the case of a patient who showed the sequential occurrence of four ... -
Carcinoma of the gastroesophageal junction in Chinese patients
(Baishideng Publishing Group, 2012)Carcinoma of the gastroesophageal junction (GEJ) is defined as carcinoma that crosses the GEJ line, irrespective of where the tumor epicenter is located. This group of cancer is rare but controversial. Based on study results ... -
Cardiac and inflammatory biomarkers do not correlate with volume of heart or lung receiving radiation
(BioMed Central, 2015)Background: Thoracic and cardiac irradiation increases the risk of pulmonary and cardiovascular disease. In addition, radiation, often in combination with chemotherapy, can cause treatment-related pneumonitis. Previously, ... -
Cardiac Angiogenic Imbalance Leads to Peripartum Cardiomyopathy
(Nature Publishing Group, 2012)Peripartum cardiomyopathy (PPCM) is an often fatal disease that affects pregnant women who are near delivery, and it occurs more frequently in women with pre-eclampsia and/or multiple gestation. The aetiology of PPCM, and ... -
Cardiac Autoimmunity as a Novel Biomarker, Mediator, and Therapeutic Target of Heart Disease in Type 1 Diabetes
(Springer US, 2015)Patients with type 1 diabetes (T1D) suffer excess mortality from cardiovascular disease (CVD) that has persisted despite substantial reductions in microvascular complications. Although T1D and type 2 diabetes (T2D) are ... -
Cardiac Autonomic Dysfunction: Particulate Air Pollution Effects Are Modulated by Epigenetic Immunoregulation of Toll‐like Receptor 2 and Dietary Flavonoid Intake
(Blackwell Publishing Ltd, 2015)Background: Short‐term fine particles (PM2.5) exposure is associated with reduced heart rate variability, a strong predictor of cardiac mortality among older people. Identifying modifiable factors that confer susceptibility ... -
Cardiac Hypertrophy Involves both Myocyte Hypertrophy and Hyperplasia in Anemic Zebrafish
(Public Library of Science, 2009)Background: An adult zebrafish heart possesses a high capacity of regeneration. However, it has been unclear whether and how myocyte hyperplasia contributes to cardiac remodeling in response to biomechanical stress and ... -
Cardiac Magnetic Resonance Assessment of Interstitial Myocardial Fibrosis and Cardiomyocyte Hypertrophy in Hypertensive Mice Treated With Spironolactone
(Blackwell Publishing Ltd, 2014)Background: Nearly 50% of patients with heart failure (HF) have preserved LV ejection fraction, with interstitial fibrosis and cardiomyocyte hypertrophy as early manifestations of pressure overload. However, methods to ... -
Cardiac mitochondria exhibit dynamic functional clustering
(Frontiers Media S.A., 2014)Multi-oscillatory behavior of mitochondrial inner membrane potential ΔΨm in self-organized cardiac mitochondrial networks can be triggered by metabolic or oxidative stress. Spatio-temporal analyses of cardiac mitochondrial ... -
Cardiac MRI with Concurrent Physiological Monitoring Using MRI-Compatible 12-Lead ECG
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Cardiac Output Monitoring Managing Intravenous Therapy (COMMIT) to Treat Emergency Department Patients with Sepsis
(Lippincott Williams & Wilkins, 2016)ABSTRACT Objective: Fluid responsiveness is proposed as a physiology-based method to titrate fluid therapy based on preload dependence. The objectives of this study were to determine if a fluid responsiveness protocol would ... -
Cardiac sarcoidosis with severe involvement of the right ventricle: a case report
(São Paulo, SP: Universidade de São Paulo, Hospital Universitário, 2015)We present the case of a patient who underwent cardiac transplantation with the diagnosis of idiopathic dilated cardiomyopathy. Once the explanted heart was examined, a type of granulomatous myocarditis compatible with ... -
Cardiac Sarcoidosis: Case Report, Workup, and Review of the Literature
(Springer Healthcare, 2013)Introduction: Cardiovascular disease is the leading cause of death worldwide, with coronary heart disease being the most common manifestation disease. While deaths attributed to coronary heart disease are falling in the ...