Browsing HMS Scholarly Articles by Title
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CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft Survival
(Public Library of Science, 2013)CD160 is a cell surface molecule expressed by most NK cells and approximately 50% of CD8+ cytotoxic T lymphocytes. Engagement of CD160 by MHC class-I directly triggers a costimulatory signal to TCR-induced proliferation, ... -
CD1a autoreactive T cells recognize natural skin oils that function as headless antigens
(2014)CD1a autoreactive T cells are common in human blood and skin, but the search for natural autoantigens has been confounded by background T cell responses to CD1 proteins and self lipids. After capturing CD1a-lipid complexes, ... -
CD1b Tetramers Bind \(\alpha \beta\) T Cell Receptors to Identify a Mycobacterial Glycolipid-Reactive T Cell Repertoire in Humans
(The Rockefeller University Press, 2011)Microbial lipids activate T cells by binding directly to CD1 and T cell receptors (TCRs) or by indirect effects on antigen-presenting cells involving induction of lipid autoantigens, CD1 transcription, or cytokine release. ... -
CD1c Bypasses Lysosomes to Present a Lipopeptide Antigen with 12 Amino Acids
(The Rockefeller University Press, 2009)The recent discovery of dideoxymycobactin (DDM) as a ligand for CD1a demonstrates how a nonribosomal lipopeptide antigen is presented to T cells. DDM contains an unusual acylation motif and a peptide sequence present only ... -
CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids
(The Rockefeller University Press, 2009)The recent discovery of dideoxymycobactin (DDM) as a ligand for CD1a demonstrates how a nonribosomal lipopeptide antigen is presented to T cells. DDM contains an unusual acylation motif and a peptide sequence present only ... -
CD2 regulates responsiveness of activated T cells to interleukin 12.
(Rockefeller University Press, 1995)Interleukin (IL) 12 is a 70-kD heterodimeric cytokine produced by antigen-presenting cells (APCs) such as macrophages in response to infectious pathogens and interferon (IFN) gamma. The varied immunomodulatory effects of ... -
CD200 increases alternatively activated macrophages through cAMP-response element binding protein - C/EBP-beta signaling
(Wiley, 2016)The concept of macrophage polarization toward different phenotypes after CNS injury has been increasingly discussed. Here, we propose that CD200 treatment may help shift pro-inflammatory macrophages to an arginase 1 (Arg1)-, ... -
CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation
(SAGE Publications, 2016)There are numerous barriers to white matter repair after CNS injury and the underlying mechanisms remain to be fully understood. In this study, we propose the hypothesis that inflammatory macrophages in damaged white matter ... -
CD200R1 Supports HSV-1 Viral Replication and Licenses Pro-Inflammatory Signaling Functions of TLR2
(Public Library of Science, 2012)The CD200R1:CD200 axis is traditionally considered to limit tissue inflammation by down-regulating pro-inflammatory signaling in myeloid cells bearing the receptor. We generated CD200R1−/− mice and employed them to explore ... -
CD28 Costimulation Regulates Genome-Wide Effects on Alternative Splicing
(Public Library of Science, 2012)CD28 is the major costimulatory receptor required for activation of naïve T cells, yet CD28 costimulation affects the expression level of surprisingly few genes over those altered by TCR stimulation alone. Alternate splicing ... -
CD28 Ligation Increases Macrophage Suppression of T Cell Proliferation
(Nature Publishing Group, 2012)When compared to spleen or lymph node cells, resident peritoneal cavity cells respond poorly to T cell activation in vitro. The greater proportional representation of macrophages in this cell source has been shown to ... -
CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
(2013)In our functional dissection of the CD33 Alzheimer’s disease susceptibility locus, we find that the rs3865444C risk allele is associated with greater cell surface expression of CD33 in monocytes (t50 = 10.06, pjoint=1.3×10–13) ... -
CD36 coordinates NLRP3 inflammasome activation by facilitating the intracellular nucleation from soluble to particulate ligands in sterile inflammation
(2013)Particulate ligands including cholesterol crystals and amyloid fibrils induce NLRP3-dependent production of interleukin-1β (IL-1β) in atherosclerosis, Alzheimer's disease and diabetes. Soluble endogenous ligands including ... -
CD39 and CD161 Modulate Th17 Responses in Crohn's Disease
(The American Association of Immunologists, 2014-08-29)CD39 (ENTPD1) is expressed by subsets of pathogenic human CD4+ T cells, such as T helper type 17 (Th17) cells. These Th17 cells are considered important in intestinal inflammation, such as seen in Crohn’s disease. Recently, ... -
CD39 and Control of Cellular Immune Responses
(Springer Verlag, 2007)CD39 is the cell surface-located prototypic member of the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. Biological actions of CD39 are a consequence (at least in part) of the regulated phosphohydrolytic ... -
CD39 deficiency in murine liver allografts promotes inflammatory injury and immune-mediated rejection
(2015)Adenosine triphosphate (ATP), an essential metabolic energy source, is released following cell apoptosis or necrosis. It acts as a damage-associated molecule pattern to stimulate innate immune cells. The ectonucleotidase ... -
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells
(Public Library of Science, 2015)Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially ... -
CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease
(Public Library of Science, 2016)IFN-γ–producing CD4 T cells are required for protection against Mycobacterium tuberculosis (Mtb) infection, but the extent to which IFN-γ contributes to overall CD4 T cell-mediated protection remains unclear. Furthermore, ... -
CD4+ and viral load outcomes of antiretroviral therapy switch strategies after virologic failure of combination antiretroviral therapy in perinatally HIV-infected youth in the United States
(Lippincott Williams & Wilkins, 2015)Objective: This study compared 12-month CD4+ and viral load outcomes in HIV-infected children and adolescents with virological failure, managed with four treatment switch strategies. Design: This observational study included ... -
CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells
(Springer-Verlag, 2012)CD40L has a well-established role in enhancing the immunostimulatory capacity of normal and malignant B cells, but a formulation suitable for clinical use has not been widely available. Like other TNF family members, in ...