Browsing HMS Scholarly Articles by Title
Now showing items 2258-2277 of 17922
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CDX2 Expression in the Intestinal-Type Gastric Epithelial Neoplasia: Frequency and Significance.
(Nature Publishing Group, 2010)CDX2 is an intestinal transcription factor responsible for regulating the proliferation and differentiation of intestinal epithelial cells. In gastric adenocarcinoma, CDX2 expression is known to be associated with limited ... -
Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model
(National Academy of Sciences, 2006)HOX genes have emerged as critical effectors of leukelmogenesis, but the mechanisms that regulate their expression in leukemia are not well understood. Recent data suggest that the caudal homeobox transcription factors ... -
CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells
(The Rockefeller University Press, 2011)Although carcinoembryonic antigen (CEA)–related cell adhesion molecule 1 (CEACAM1) has been viewed as a tumor suppressor, increasing clinical evidence shows that high levels of CEACAM1 expression on tumors correlates ... -
CEACAM6 Gene Variants in Inflammatory Bowel Disease
(Public Library of Science, 2011)Background: The carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) acts as a receptor for adherentinvasive E. coli (AIEC) and its ileal expression is increased in patients with Crohn’s disease (CD). Given ... -
Ceftaroline Desensitization Procedure in a Pregnant Patient With Multiple Drug Allergies
(Oxford University Press, 2015)Validated skin testing is lacking for many drugs, including ceftaroline. The cross-reactivity between ceftaroline and other β-lactam antibiotics is unknown. We report a case of a pregnant patient with cystic fibrosis and ... -
Celebrity Suicides and Their Differential Influence on Suicides in the General Population: A National Population-Based Study in Korea
(Korean Neuropsychiatric Association, 2015)Objective: Although evidence suggests that there is an increase in suicide rates in the general population following celebrity suicide, the rates are heterogeneous across celebrities and countries. It is unclear which is ... -
Celecoxib inhibits early cutaneous wound healing
(Elsevier BV, 2015)BACKGROUND: Cyclooxygenase-2 (COX-2) is an inducible enzyme that is rapidly upregulated in response to injury, resulting in the production of prostaglandin E2 (PGE2), a primary mediator of inflammation and wound healing. ... -
Celiac Disease Genomic, Environmental, Microbiome, and Metabolomic (CDGEMM) Study Design: Approach to the Future of Personalized Prevention of Celiac Disease
(MDPI, 2015)In the past it was believed that genetic predisposition and exposure to gluten were necessary and sufficient to develop celiac disease (CD). Recent studies however suggest that loss of gluten tolerance can occur at any ... -
Celiac Disease Histopathology Recapitulates Hedgehog Downregulation, Consistent with Wound Healing Processes Activation
(Public Library of Science, 2015)Background: In celiac disease (CD), intestinal epithelium damage occurs secondary to an immune insult and is characterized by blunting of the villi and crypt hyperplasia. Similarities between Hedgehog (Hh)/BMP4 downregulation, ... -
Cell biology of fat storage
(The American Society for Cell Biology, 2016)The worldwide epidemic of obesity and type 2 diabetes has greatly increased interest in the biology and physiology of adipose tissues. Adipose (fat) cells are specialized for the storage of energy in the form of triglycerides, ... -
Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity
(eLife Sciences Publications, Ltd, 2016)Mammalian lifespan differs by >100 fold, but the mechanisms associated with such longevity differences are not understood. Here, we conducted a study on primary skin fibroblasts isolated from 16 species of mammals and ... -
Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons
(Nature Publishing Group, 2015)The direct conversion of fibroblasts to induced dopaminergic (iDA) neurons and other cell types demonstrates the plasticity of cell fate. The low efficiency of these relatively fast conversions suggests that kinetic barriers ... -
Cell Death Pathways in Photodynamic Therapy of Cancer
(Molecular Diversity Preservation International (MDPI), 2011)Photodynamic therapy (PDT) is an emerging cancer therapy that uses the combination of non-toxic dyes or photosensitizers (PS) and harmless visible light to produce reactive oxygen species and destroy tumors. The PS can be ... -
Cell Density Plays a Critical Role in Ex Vivo Expansion of T Cells for Adoptive Immunotherapy
(Hindawi Publishing Corporation, 2010)The successful ex vivo expansion of a large numbers of T cells is a prerequisite for adoptive immunotherapy. In this study, we found that cell density had important effects on the process of expansion of T cells in vitro. ... -
Cell Elasticity Determines Macrophage Function
(Public Library of Science, 2012)Macrophages serve to maintain organ homeostasis in response to challenges from injury, inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has been understood as being the central ... -
A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression
(Landes Bioscience, 2013)Brain cellular heterogeneity may bias cell type specific DNA methylation patterns, influencing findings in psychiatric epigenetic studies. We performed fluorescence activated cell sorting (FACS) of neuronal nuclei and ... -
The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML
(The Rockefeller University Press, 2013)A unique characteristic of hematopoietic stem cells (HSCs) is the ability to self-renew. Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSCs and potentially also ... -
Cell Kinetic Studies Fail to Identify Sequentially Proliferating Progenitors as the Major Source of Epithelial Renewal in the Adult Murine Prostate
(Public Library of Science, 2015)There is evidence that stem cells and their progeny play a role in the development of the prostate. Although stem cells are also considered to give rise to differentiated progeny in the adult prostate epithelium ex vivo, ... -
Cell Labeling and Tracking Method without Distorted Signals by Phagocytosis of Macrophages
(Ivyspring International Publisher, 2014)Cell labeling and tracking are important processes in understanding biologic mechanisms and the therapeutic effect of inoculated cells in vivo. Numerous attempts have been made to label and track inoculated cells in vivo; ... -
Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study
(Springer Nature, 2009)The diagnosis of gastric epithelial dysplasia, a precursor lesion of gastric adenocarcinoma, is hindered by interobserver variability and by its resemblance to regenerative changes. Loss of cell polarity, a histological ...