Browsing HMS Scholarly Articles by Title

Now showing items 2321-2340 of 17922

    • Central Nervous System Involvement by Waldenström Macroglobulinaemia (Bing-Neel Syndrome): A Multi-Institutional Retrospective Study 

      Castillo, Jorge; D'Sa, Shirley; Lunn, Michael P.; Minnema, Monique C.; Tedeschi, Alessandra; Lansigan, Frederick; Palomba, M. Lia; Varettoni, Marzia; Garcia-Sanz, Ramon; Nayak, Lakshmi; Lee, Eudocia Q.; Rinne, Mikael; Norden, Andrew D.; Ghobrial, Irene; Treon, Steven (Wiley, 2016-03)
      Bing-Neel syndrome (BNS) is a rare complication seen in patients with Waldenström macroglobulinaemia (WM), in which lymphoplasmacytic lymphoma (LPL) cells colonize the central nervous system (CNS). In this retrospective ...

    • Central role for PICALM in amyloid–β blood–brain barrier transcytosis and clearance 

      Zhao, Zhen; Sagare, Abhay P.; Ma, Qingyi; Halliday, Matthew R.; Kong, Pan; Kisler, Kassandra; Winkler, Ethan A.; Ramanathan, Anita; Kanekiyo, Takahisa; Bu, Guojun; Owens, Nelly Chuqui; Rege, Sanket V.; Si, Gabriel; Ahuja, Ashim; Zhu, Donghui; Miller, Carol A.; Schneider, Julie A.; Maeda, Manami; Maeda, Takahiro; Sugawara, Tohru; Ichida, Justin K.; Zlokovic, Berislav V. (2015)
      PICALM is highly validated genetic risk factor for Alzheimer’s disease (AD). Here, we report that PICALM reductions in AD and murine brain endothelium correlate with amyloid–β (Aβ) pathology and cognitive impairment. ...

    • Central Role of SREBP-2 in the Pathogenesis of Osteoarthritis 

      Kostopoulou, Fotini; Gkretsi, Vasiliki; Malizos, Konstantinos N.; Iliopoulos, Dimitrios; Oikonomou, Pagona; Poultsides, Lazaros; Tsezou, Aspasia (Public Library of Science, 2012)
      Background: Recent studies have implied that osteoarthritis (OA) is a metabolic disease linked to deregulation of genes involved in lipid metabolism and cholesterol efflux. Sterol Regulatory Element Binding Proteins (SREBPs) ...

    • Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse 

      Ueki, Kohjiro; Kondo, Tatsuya; Tseng, Yu-Hua; Kahn, C. Ronald (National Academy of Sciences, 2004)
      Insulin resistance, obesity, diabetes, dyslipidemia, and nonalcoholic fatty liver are components of the metabolic syndrome, a disease complex that is increasing at epidemic rates in westernized countries. Although ...

    • The central role of the prefrontal cortex in directing attention to novel events 

      Daffner, Kirk R. (Oxford University Press (OUP), 2000)
      The physiological basis for the striking decrease of attention to novel events following frontal lobe injury is poorly understood. In this study, event-related potentials (ERPs) were recorded from patients with frontal ...

    • Centromere-specific histone Cse4 by the chaperone Scm3 

      Cho, Uhn-Soo; Harrison, Stephen C. (BioMed Central, 2013)

    • Centrosome Dysfunction Contributes to Chromosome Instability, Chromoanagenesis, and Genome Reprograming in Cancer 

      Pihan, German A. (Frontiers Media S.A., 2013)
      The unique ability of centrosomes to nucleate and organize microtubules makes them unrivaled conductors of important interphase processes, such as intracellular payload traffic, cell polarity, cell locomotion, and organization ...

    • CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base 

      Wang, Won-Jing; Tay, Hwee Goon; Soni, Rajesh; Perumal, Geoffrey S.; Goll, Mary G.; Macaluso, Frank P.; Asara, John M.; Amack, Jeffrey D.; Tsou, Meng-Fu Bryan (2013)
      The transition zone (TZ) is a specialized compartment found at the base of cilia, adjacent to the centriole distal end, where axonemal microtubules (MTs) are heavily cross-linked to the surrounding membrane to form a barrier ...

    • Cephalopod genomics: A plan of strategies and organization 

      Albertin, Caroline B.; Bonnaud, Laure; Brown, C. Titus; Crookes-Goodson, Wendy J.; da Fonseca, Rute R.; Di Cristo, Carlo; Dilkes, Brian P.; Edsinger-Gonzales, Eric; Freeman, Robert M; Hanlon, Roger T.; Koenig, Kristen M.; Lindgren, Annie R.; Martindale, Mark Q.; Minx, Patrick; Moroz, Leonid L.; Nödl, Marie-Therese; Nyholm, Spencer V.; Ogura, Atsushi; Pungor, Judit R.; Rosenthal, Joshua J. C.; Schwarz, Erich M.; Shigeno, Shuichi; Strugnell, Jan M.; Wollesen, Tim; Zhang, Guojie; Ragsdale, Clifton W. (Michigan State University, 2012)
      The Cephalopod Sequencing Consortium (CephSeq Consortium) was established at a NESCent Catalysis Group Meeting, “Paths to Cephalopod Genomics- Strategies, Choices, Organization,” held in Durham, North Carolina, USA on May ...

    • Cerebellar associative sensory learning defects in five mouse autism models 

      Kloth, Alexander D; Badura, Aleksandra; Li, Amy; Cherskov, Adriana; Connolly, Sara G; Giovannucci, Andrea; Bangash, M Ali; Grasselli, Giorgio; Peñagarikano, Olga; Piochon, Claire; Tsai, Peter T; Geschwind, Daniel H; Hansel, Christian; Sahin, Mustafa; Takumi, Toru; Worley, Paul F; Wang, Samuel S-H (eLife Sciences Publications, Ltd, 2015)
      Sensory integration difficulties have been reported in autism, but their underlying brain-circuit mechanisms are underexplored. Using five autism-related mouse models, Shank3+/ΔC, Mecp2R308/Y, Cntnap2−/−, L7-Tsc1 ...

    • Cerebral Blood Flow Velocity and Periventricular White Matter Hyperintensities in Type 2 Diabetes 

      Novak, Vera; Last, David; Alsop, David; Abduljalil, Amir; Hu, Kun; Lepicovsky, Lukas; Cavallerano, Jerry; Lipsitz, Lewis (American Diabetes Association, 2006-07)
      OBJECTIVE Diabetes increases the risk for cerebromicrovascular disease, possibly through its effects on blood flow regulation. The aim of this study was to assess the effects of type 2 diabetes on blood flow velocities ...

    • Cerebral Blood Flow, Heart Rate, and Blood Pressure Patterns during the Tilt Test in Common Orthostatic Syndromes 

      Novak, Peter (Hindawi Publishing Corporation, 2016)
      Objective:. The head-up tilt test is widely used for evaluation of orthostatic intolerance. Although orthostatic symptoms usually reflect cerebral hypoperfusion, the cerebral blood flow velocity (CBFv) profile in orthostatic ...

    • Cerebral Circulation Time is Prolonged and Not Correlated with EDSS in Multiple Sclerosis Patients: A Study Using Digital Subtracted Angiography 

      Monti, Lucia; Donati, Donatella; Menci, Elisabetta; Cioni, Samuele; Bellini, Matteo; Grazzini, Irene; Leonini, Sara; Galluzzi, Paolo; Severi, Sauro; Burroni, Luca; Casasco, Alfredo; Morbidelli, Lucia; Santarnecchi, Emiliano; Piu, Pietro (Public Library of Science, 2015)
      Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and ...

    • Cerebral edema and a transtentorial brain herniation syndrome associated with pandemic swine influenza A (H1N1) virus infection 

      Kahle, Kristopher; Walcott, Brian; Nahed, Brian Vala; Barnard, Zachary R.; Lo, Eng H.; Buonanno, Ferdinando Stelio; Venna, Nagagopal; Ning, MingMing (Elsevier BV, 2011)
      Acute encephalitis, encephalopathy, and seizures are known rare neurologic sequelae of respiratory tract infection with seasonal influenza A and B virus, but the neurological complications of the pandemic 2009 swine influenza ...

    • Cerebral versus Ocular Visual Impairment: The Impact on Developmental Neuroplasticity 

      Martín, Maria B. C.; Santos-Lozano, Alejandro; Martín-Hernández, Juan; López-Miguel, Alberto; Maldonado, Miguel; Baladrón, Carlos; Bauer, Corinna M.; Merabet, Lotfi B. (Frontiers Media S.A., 2016)
      Cortical/cerebral visual impairment (CVI) is clinically defined as significant visual dysfunction caused by injury to visual pathways and structures occurring during early perinatal development. Depending on the location ...

    • Cerebral white matter abnormalities and their associations with negative but not positive symptoms of schizophrenia 

      Asami, Takeshi; Hyuk Lee, Sang; Bouix, Sylvain; Rathi, Yogesh; Whitford, Thomas; Niznikiewicz, Margaret A.; Nestor, Paul Gerard; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Elsevier BV, 2014)
      Although diffusion tensor imaging (DTI) studies have reported fractional anisotropy (FA) abnormalities in multiple white matter (WM) regions in schizophrenia, relationship between abnormal FA and negative symptoms has not ...

    • Cerebrospinal fluid amyloid-β 42/40 ratio in clinical setting of memory centers: a multicentric study 

      Dumurgier, Julien; Schraen, Susanna; Gabelle, Audrey; Vercruysse, Olivier; Bombois, Stéphanie; Laplanche, Jean-Louis; Peoc’h, Katell; Sablonnière, Bernard; Kastanenka, Ksenia V; Delaby, Constance; Pasquier, Florence; Touchon, Jacques; Hugon, Jacques; Paquet, Claire; Lehmann, Sylvain (BioMed Central, 2015)
      Introduction: The cerebrospinal fluid (CSF) biomarkers amyloid-β (Aβ), tau and phosphorylated tau (p-tau181) are now used for the diagnosis of Alzheimer’s disease (AD). Aβ40 is the most abundant Aβ peptide isoform in the ...

    • Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus 

      Leinonen, Ville; Menon, Lata G.; Carroll, Rona Stephanie; Dello Iacono, Donna; Grevet, Jeremy; Jääskeläinen, Juha E.; Black, Peter McLaren (SAGE-Hindawi Access to Research, 2011)
      The diagnosis of idiopathic normal pressure hydrocephalus (iNPH) is still challenging. Alzheimer's disease (AD), along with vascular dementia, the most important differential diagnosis for iNPH, has several potential ...

    • Cerebrospinal fluid matrix metalloproteinase-9 increases during treatment of recurrent malignant gliomas 

      Wong, Eric; Alsop, David; Lee, Diana; Tam, Angela; Barron, Loretta; Bloom, Julianne; Gautam, Shiva; Wu, Julian K. (Springer Science and Business Media LLC, 2008-01-11)
      Background Matrix metalloproteinases (MMPs) are enzymes that promote tumor invasion and angiogenesis by enzymatically remodeling the extracellular matrix. MMP-2 and MMP-9 are the most abundant forms of MMPs in malignant ...

    • Cerebrospinal fluid metabolomics reveals altered waste clearance and accelerated aging in HIV patients with neurocognitive impairment 

      Cassol, Edana; Misra, Vikas; Dutta, Anupriya; Morgello, Susan; Gabuzda, Dana (Lippincott Williams & Wilkins, 2014)
      Objective(s): HIV-associated neurocognitive disorders (HAND) remain prevalent in HIV-infected patients on antiretroviral therapy (ART), but the underlying mechanisms are unclear. Some features of HAND resemble those of ...