Browsing HMS Scholarly Articles by Title

Now showing items 234-253 of 17922

    • Accumulated Lead Exposure and Risk of Age-Related Cataract in Men 

      Schaumberg, Debra Ann; Mendes, Flavia; Balaram, Mini; Dana, Reza; Sparrow, David; Hu, Howard (American Medical Association (AMA), 2004)
      Context Low-level lead exposure may increase the risk for a number of chronic age-related diseases. Several studies have documented the presence of lead in lenses with cataract. The intrusion of lead into the lens may alter ...

    • Accumulation of Metabolic Cardiovascular Risk Factors in Black and White Young Adults Over 20 Years 

      Paynter, Nina P.; Kiefe, Catarina I.; Lewis, Cora E.; Loria, Catherine M.; Goff, David C.; Lloyd‐Jones, Donald M. (Blackwell Publishing Ltd, 2015)
      Background: Cross‐sectional clustering of metabolic risk factors for cardiovascular disease in middle‐aged adults is well described, but less is known regarding the order in which risk factors develop through young adulthood ...

    • Accumulation of Protease Mutations among Patients Failing Second-Line Antiretroviral Therapy and Response to Salvage Therapy in Nigeria 

      Rawizza, Holly E.; Chaplin, Beth; Meloni, Seema T.; Darin, Kristin M.; Olaitan, Oluremi; Scarsi, Kimberly K.; Onwuamah, Chika K.; Audu, Rosemary A.; Chebu, Philippe R.; Imade, Godwin E.; Okonkwo, Prosper; Kanki, Phyllis J. (Public Library of Science, 2013)
      Background: To date, antiretroviral therapy (ART) guidelines and programs in resource-limited settings (RLS) have focused on 1st- and 2nd-line (2 L) therapy. As programs approach a decade of implementation, policy regarding ...

    • Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation 

      Cortes, Mauricio; Liu, Sarah Y.; Kwan, Wanda; Alexa, Kristen; Goessling, Wolfram; North, Trista E. (Elsevier, 2015)
      Summary Hematopoietic stem and progenitor cells (HSPCs) are born from hemogenic endothelium in the dorsal aorta. Specification of this hematopoietic niche is regulated by a signaling axis using Hedgehog (Hh) and Notch, ...

    • Accumulation of Tissue Factor into Developing Thrombi in Vivo Is Dependent upon Microparticle P-Selectin Glycoprotein Ligand 1 and Platelet P-Selectin 

      Falati, Shahrokh; Liu, Qingde; Gross, Peter; Merrill-Skoloff, Glenn; Chou, Janet; Vandendries, Erik; Celi, Alessandro; Croce, Kevin; Furie, Barbara C.; Furie, Bruce (Rockefeller University Press, 2003)
      Using a laser-induced endothelial injury model, we examined thrombus formation in the microcirculation of wild-type and genetically altered mice by real-time in vivo microscopy to analyze this complex physiologic process ...

    • Accuracy and Precision in Quantitative Fluorescence Microscopy 

      Waters, Jennifer Catherine (The Rockefeller University Press, 2009)
      The light microscope has long been used to document the localization of fluorescent molecules in cell biology research. With advances in digital cameras and the discovery and development of genetically encoded fluorophores, ...

    • Accuracy and reproducibility of automated, standardized coronary transluminal attenuation gradient measurements 

      Chatzizisis, Yiannis; George, Elizabeth; Cai, Tianrun; Fulwadhva, Urvi P; Kumamaru, Kanako; Schultz, Kurt; Fujisawa, Yasuko; Rassi, Carlos; Steigner, Michael L.; Mather, Richard T.; Blankstein, Ron; Rybicki, Frank; Mitsouras, Dimitrios (Springer Nature, 2014)
      Purpose Coronary Computed Tomography Angiography (CCTA) contrast opacification gradients, or Transluminal Attenuation Gradients (TAG) offer incremental value to predict functionally significant lesions. This study ...

    • Accuracy of administrative data for surveillance of healthcare-associated infections: a systematic review 

      van Mourik, Maaike S M; van Duijn, Pleun Joppe; Moons, Karel G M; Bonten, Marc J M; Lee, Grace M (BMJ Publishing Group, 2015)
      Objective: Measuring the incidence of healthcare-associated infections (HAI) is of increasing importance in current healthcare delivery systems. Administrative data algorithms, including (combinations of) diagnosis codes, ...

    • Accuracy of CT Colonography for Detection of Polypoid and Nonpolypoid Neoplasia by Gastroenterologists and Radiologists: A Nationwide Multicenter Study in Japan 

      Nagata, Koichi; Endo, Shungo; Honda, Tetsuro; Yasuda, Takaaki; Hirayama, Michiaki; Takahashi, Sho; Kato, Takashi; Horita, Shoichi; Furuya, Ken; Kasai, Kenji; Matsumoto, Hiroshi; Kimura, Yoshiki; Utano, Kenichi; Sugimoto, Hideharu; Kato, Hiroyuki; Yamada, Rieko; Yamamichi, Junta; Shimamoto, Takeshi; Ryu, Yasuji; Matsui, Osamu; Kondo, Hitoshi; Doi, Ayako; Abe, Taro; Yamano, Hiro-o; Takeuchi, Ken; Hanai, Hiroyuki; Saida, Yukihisa; Fukuda, Katsuyuki; Näppi, Janne; Yoshida, Hiroyuki (Nature Publishing Group, 2017)
      OBJECTIVES: The objective of this study was to assess prospectively the diagnostic accuracy of computer-assisted computed tomographic colonography (CTC) in the detection of polypoid (pedunculated or sessile) and nonpolypoid ...

    • Accuracy of Electrocardiographic Criteria for Atrial Enlargement: Validation with Cardiovascular Magnetic Resonance 

      Tsao, Connie Wei-Lee; Josephson, Mark; Hauser, Thomas Henry; O'Halloran, Thomas D.; Agarwal, Anupam; Manning, Warren J.; Yeon, Susan B. (BioMed Central, 2008)
      Background: Anatomic atrial enlargement is associated with significant morbidity and mortality. However, atrial enlargement may not correlate with clinical measures such as electrocardiographic (ECG) criteria. Past studies ...

    • Accuracy of epidemiological inferences based on publicly available information: retrospective comparative analysis of line lists of human cases infected with influenza A(H7N9) in China 

      Lau, Eric HY; Zheng, Jiandong; Tsang, Tim K; Liao, Qiaohong; Lewis, Bryan; Brownstein, John S; Sanders, Sharon; Wong, Jessica Y; Mekaru, Sumiko R; Rivers, Caitlin; Wu, Peng; Jiang, Hui; Li, Yu; Yu, Jianxing; Zhang, Qian; Chang, Zhaorui; Liu, Fengfeng; Peng, Zhibin; Leung, Gabriel M; Feng, Luzhao; Cowling, Benjamin J; Yu, Hongjie (BioMed Central, 2014)
      Background: Appropriate public health responses to infectious disease threats should be based on best-available evidence, which requires timely reliable data for appropriate analysis. During the early stages of epidemics, ...

    • Accuracy of Inferior Vena Cava Ultrasound for Predicting Dehydration in Children with Acute Diarrhea in Resource-Limited Settings 

      Modi, Payal; Glavis-Bloom, Justin; Nasrin, Sabiha; Guy, Allysia; Chowa, Erika P.; Dvor, Nathan; Dworkis, Daniel A.; Oh, Michael; Silvestri, David M.; Strasberg, Stephen; Rege, Soham; Noble, Vicki E.; Alam, Nur H.; Levine, Adam C. (Public Library of Science, 2016)
      Introduction: Although dehydration from diarrhea is a leading cause of morbidity and mortality in children under five, existing methods of assessing dehydration status in children have limited accuracy. Objective: To assess ...

    • The Accuracy of the Physical Examination for the Diagnosis of Midlumbar and Low Lumbar Nerve Root Impingement 

      Suri, Pradeep; Rainville, James; Katz, Jeffrey; Jouve, Cristin; Hartigan, Carol; Limke, Janet; Pena, Enrique; Li, Ling; Swaim, Bryan; Hunter, David J. (Ovid Technologies (Wolters Kluwer Health), 2011)
      Study Design: Cross-sectional study with prospective recruitment. Objective: To determine the accuracy of the physical examination for the diagnosis of midlumbar nerve root impingement (L2, L3, or L4), low lumbar nerve ...

    • Accurate measurement of pancreatic islet β-cell mass using a second-generation fluorescent exendin-4 analog 

      Reiner, Thomas; Thurber, Greg; Gaglia, Jason; Vinegoni, Claudio; Liew, Chong Wee; Upadhyay, Rabi; Kohler, Rainer H.; Li, Li; Kulkarni, Rohit N.; Benoist, Christophe; Mathis, Diane; Weissleder, Ralph (National Academy of Sciences, 2011)

    • Accurate Whole Genome Sequencing as the Ultimate Genetic Test 

      Drmanac, R.; Peters, B. A.; Church, George McDonald; Reid, Clifford; Xu, Xun (American Association for Clinical Chemistry (AACC), 2014)

    • Accurate Whole-Genome Sequencing and Haplotyping from 10 to 20 Human Cells 

      Peters, Brock A.; Kermani, Bahram G.; Sparks, Andrew B.; Alferov, Oleg; Hong, Peter; Alexeev, Andrei; Jiang, Yuan; Dahl, Fredrik; Tang, Y. Tom; Haas, Juergen; Robasky, Kimberly J.; Lee, Je-Hyuk; Peterson, Joseph E.; Perazich, Helena; Yeung, George; Liu, Jia; Chen, Linsu; Kennemer, Michael I.; Pothuraju, Kaliprasad; Konvicka, Karel; Tsoupko-Sitnikov, Mike; Pant, Krishna P.; Ebert, Jessica C.; Nilsen, Geoffrey B.; Baccash, Jonathan; Halpern, Aaron L.; Church, George McDonald; Drmanac, Radoje; Zaranek, Alexander Wait; Ball, Madeleine Price (Nature Publishing Group, 2012)
      Recent advances in whole genome sequencing have brought the vision of personal genomics and genomic medicine closer to reality. However, current methods lack clinical accuracy and the ability to describe the context ...

    • Acellular Bi-Layer Silk Fibroin Scaffolds Support Tissue Regeneration in a Rabbit Model of Onlay Urethroplasty 

      Chung, Yeun Goo; Tu, Duong; Franck, Debra; Gil, Eun Seok; Algarrahi, Khalid; Adam, Rosalyn M.; Kaplan, David L.; Estrada Jr., Carlos R.; Mauney, Joshua R. (Public Library of Science, 2014)
      Acellular scaffolds derived from Bombyx mori silk fibroin were investigated for their ability to support functional tissue regeneration in a rabbit model of urethra repair. A bi-layer silk fibroin matrix was fabricated by ...

    • Acellular Dermal Matrix in Reconstructive Breast Surgery: Survey of Current Practice among Plastic Surgeons 

      Ibrahim, Ahmed M. S.; Koolen, Pieter G. L.; Ashraf, Azra A.; Kim, Kuylhee; Mureau, Marc A. M.; Lee, Bernard T.; Lin, Samuel J. (Wolters Kluwer Health, 2015)
      Background: Acellular dermal matrices (ADMs) in plastic surgery have become increasingly popular particularly for breast reconstruction. Despite their advantages, questions exist regarding their association with a possible ...

    • Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma 

      Sheehan, William; Mauger, David T.; Paul, Ian M.; Moy, James N.; Boehmer, Susan J.; Szefler, Stanley J.; Fitzpatrick, Anne M.; Jackson, Daniel J.; Bacharier, Leonard B.; Cabana, Michael D.; Covar, Ronina; Holguin, Fernando; Lemanske, Robert F.; Martinez, Fernando D.; Pongracic, Jacqueline A.; Beigelman, Avraham; Baxi, Sachin; Benson, Mindy; Blake, Kathryn; Chmiel, James F.; Daines, Cori L.; Daines, Michael O.; Gaffin, Jonathan; Gentile, Deborah A.; Gower, W. Adam; Israel, Elliot; Kumar, Harsha V.; Lang, Jason E.; Lazarus, Stephen C.; Lima, John J.; Ly, Ngoc; Marbin, Jyothi; Morgan, Wayne J.; Myers, Ross E.; Olin, J. Tod; Peters, Stephen P.; Raissy, Hengameh H.; Robison, Rachel G.; Ross, Kristie; Sorkness, Christine A.; Thyne, Shannon M.; Wechsler, Michael E.; Phipatanakul, Wanda (Massachusetts Medical Society, 2016-08-18)
      BACKGROUND Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with ...

    • Acetylation of C/EBPα inhibits its granulopoietic function 

      Bararia, Deepak; Kwok, Hui Si; Welner, Robert S.; Numata, Akihiko; Sárosi, Menyhárt B.; Yang, Henry; Wee, Sheena; Tschuri, Sebastian; Ray, Debleena; Weigert, Oliver; Levantini, Elena; Ebralidze, Alexander K.; Gunaratne, Jayantha; Tenen, Daniel G. (Nature Publishing Group, 2016)
      CCAAT/enhancer-binding protein alpha (C/EBPα) is an essential transcription factor for myeloid lineage commitment. Here we demonstrate that acetylation of C/EBPα at lysine residues K298 and K302, mediated at least in part ...