Browsing HMS Scholarly Articles by Title
Now showing items 2445-2464 of 17922
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Characterization of Human CD39+ Th17 Cells with Suppressor Activity and Modulation in Inflammatory Bowel Disease
(Public Library of Science, 2014)Induced regulatory T-cells (iT-reg) and T helper type 17 (Th17) in the mouse share common CD4 progenitor cells and exhibit overlapping phenotypic and functional features. Here, we show that human Th17 cells endowed with ... -
Characterization of Human Thrombospondin-4
(American Society for Biochemistry and Molecular Biology, 1995) -
Characterization of Immortalized MARCO and SR-AI/II-deficient Murine Alveolar Macrophage Cell Lines
(BioMed Central, 2008)Background: Alveolar macrophages (AM) avidly bind and ingest unopsonized inhaled particles and bacteria through class A scavenger receptors (SRAs) MARCO and SR-AI/II. Studies to characterize the function of these SRAs have ... -
Characterization of Langerin-Expressing Dendritic Cell Subsets in the Normal Cornea
(Association for Research in Vision and Ophthalmology (ARVO), 2011)Purpose. In addition to Langerhans cells (LCs), other dendritic cells (CD11c+) have recently been shown to express Langerin (c-type lectin). In skin, (non-LC) Langerin+ dendritic cells initiate adaptive immunity. However, ... -
Characterization of Mammalian Selenoprotein O: A Redox-Active Mitochondrial Protein
(Public Library of Science, 2014)Selenoproteins exhibit diverse biological functions, most of which are associated with redox control. However, the functions of approximately half of mammalian selenoproteins are not known. One such protein is Selenoprotein ... -
Characterization of methionine oxidation and methionine sulfoxide reduction using methionine-rich cysteine-free proteins
(BioMed Central, 2012)Background: Methionine (Met) residues in proteins can be readily oxidized by reactive oxygen species to Met sulfoxide (MetO). MetO is a promising physiological marker of oxidative stress and its inefficient repair by MetO ... -
Characterization of Multi-Drug Resistant Enterococcus faecalis Isolated from Cephalic Recording Chambers in Research Macaques (Macaca spp.)
(Public Library of Science, 2017)Nonhuman primates are commonly used for cognitive neuroscience research and often surgically implanted with cephalic recording chambers for electrophysiological recording. Aerobic bacterial cultures from 25 macaques ... -
Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis
(Public Library of Science, 2015)Microgliosis is a major hallmark of Alzheimer’s disease (AD) brain pathology. Aβ peptide is hypothesized to act as a stimulus for microglia leading to activation of non-receptor tyrosine kinases and subsequent secretion ... -
Characterization of Phthalate Exposure among Pregnant Women Assessed by Repeat Air and Urine Samples
(National Institute of Environmental Health Sciences, 2008)Background: Although urinary concentrations of phthalate metabolites are frequently used as biomarkers in epidemiologic studies, variability during pregnancy has not been characterized. Methods: We measured phthalate ... -
Characterization of Planctomyces limnophilus and Development of Genetic Tools for Its Manipulation Establish It as a Model Species for the Phylum Planctomycetes
(American Society for Microbiology, 2011)Planctomycetes represent a remarkable clade in the domain Bacteria because they play crucial roles in global carbon and nitrogen cycles and display cellular structures that closely parallel those of eukaryotic cells. Studies ... -
Characterization of plasma thiol redox potential in a common marmoset model of aging☆
(Elsevier, 2013)Due to its short lifespan, ease of use and age-related pathologies that mirror those observed in humans, the common marmoset (Callithrix jacchus) is poised to become a standard nonhuman primate model of aging. Blood and ... -
Characterization of Poliovirus Neutralization Escape Mutants of Single-Domain Antibody Fragments (VHHs)
(American Society for Microbiology, 2015)To complete the eradication of poliovirus and to protect unvaccinated people subsequently, the development of one or more antiviral drugs will be necessary. A set of five single-domain antibody fragments (variable parts ... -
Characterization of protein kinase C isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization
(Proceedings of the National Academy of Sciences, 2002)Retinal neovascularization is a major cause of blindness and requires the activities of several signaling pathways and multiple cytokines. Activation of protein kinase C (PKC) enhances the angiogenic process and is involved ... -
Characterization of Receptor-Mediated Signal Transduction by Escherichia coli Type IIa Heat-Labile Enterotoxin in the Polarized Human Intestinal Cell Line T84
(American Society for Microbiology, 2001) -
Characterization of Respiratory and Cardiac Motion from Electro-Anatomical Mapping Data for Improved Fusion of MRI to Left Ventricular Electrograms
(Public Library of Science, 2013)Accurate fusion of late gadolinium enhancement magnetic resonance imaging (MRI) and electro-anatomical voltage mapping (EAM) is required to evaluate the potential of MRI to identify the substrate of ventricular tachycardia. ... -
Characterization of Ribeye Subunits in Zebrafish Hair Cells Reveals That Exogenous Ribeye B-Domain and CtBP1 Localize to the Basal Ends of Synaptic Ribbons
(Public Library of Science, 2014)Synaptic ribbons are presynaptic structures formed by the self-association of RIBEYE–the main structural component of ribbon synapses. RIBEYE consists of two domains: a unique N-terminal A-domain and a C-terminal B-domain ... -
Characterization of selective and potent PI3Kδ inhibitor (PI3KD-IN-015) for B-Cell malignances
(Impact Journals LLC, 2016)PI3Kδ is predominately expressed in leukocytes and has been found overexpressed in B-cell related malignances such as CLL and AML. We have discovered a highly selective ATP competitive PI3Kd inhibitor PI3KD-IN-015, which ... -
Characterization of smooth muscle-like cells in circulating human peripheral blood
(Elsevier BV, 2006)Smooth muscle cells play an important role in human vascular diseases. Several lines of evidence demonstrate that circulating smooth muscle precursor cells contribute to intimal hyperplasia in animal models. We obtained ... -
Characterization of the "Deqi" Response in Acupuncture
(Springer Science and Business Media LLC, 2007-10-31)Background: Acupuncture stimulation elicits deqi, a composite of unique sensations that is essential for clinical efficacy according to traditional Chinese medicine (TCM). There is lack of adequate experimental data to ...