Browsing HMS Scholarly Articles by Title

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    • Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture. 

      Lipton, S. A.; Wagner, John A.; Madison, Roger D.; D'Amore, Patricia Ann (Proceedings of the National Academy of Sciences, 1988)
      Postnatal rat retinal ganglion cells (RGCs) were identified with specific fluorescent labels and placed in culture. Under these conditions, the outgrowth of processes by RGCs was found to be promoted to a far greater degree ...

    • Acid–base balance, serum electrolytes and need for non-invasive ventilation in patients with hypercapnic acute exacerbation of chronic obstructive pulmonary disease admitted to an internal medicine ward 

      Schiavo, Alfonso; Renis, Maurizio; Polverino, Mario; Iannuzzi, Arcangelo; Polverino, Francesca (BioMed Central, 2016)
      Background: Hypoventilation produces or worsens respiratory acidosis in patients with hypercapnia due to acute exacerbations of chronic obstructive pulmonary disease (AECOPD). In these patients acid–base and hydroelectrolite ...

    • Acinar Cystadenoma of the Pancreas 

      Khor, Tze S.; Badizadegan, Kamran; Ferrone, Cristina Rosa; Fernandez-Del Castillo, Carlos F.; Desai, Gaurav S.; Saenz, Adam; Le, Long Phi; Lauwers, Gregory Y.; Deshpande, Vikram (Ovid Technologies (Wolters Kluwer Health), 2012)
      Pancreatic acinar cystadenomas (ACAs) are rare cystic lesions showing acinar differentiation with benign outcome. Although debated, ACAs are favored to be neoplastic and potentially the benign counterpart of acinar ...

    • ACME: Automated Cell Morphology Extractor for Comprehensive Reconstruction of Cell Membranes 

      Mosaliganti, Kishore Rao; Noche, Ramil; Xiong, Fengzhu; Swinburne, Ian A; Megason, Sean G. (Public Library of Science, 2012)
      The quantification of cell shape, cell migration, and cell rearrangements is important for addressing classical questions in developmental biology such as patterning and tissue morphogenesis. Time-lapse microscopic imaging ...

    • Acne Treatment Based on Selective Photothermolysis of Sebaceous Follicles with Topically Delivered Light-Absorbing Gold Microparticles 

      Paithankar, Dilip Y; Sakamoto, Fernanda H; Farinelli, William A; Kositratna, Garuna; Blomgren, Richard D; Meyer, Todd J; Faupel, Linda J; Kauvar, Arielle N B; Lloyd, Jenifer R; Cheung, Wang L; Owczarek, Witold D; Suwalska, Anna M; Kochanska, Katarzyna B; Nawrocka, Agnieszka K; Paluchowska, Elwira B; Podolec, Katarzyna M; Pirowska, Magdalena M; Wojas-Pelc, Anna B; Anderson, R Rox (Nature Publishing Group, 2015)
      The pathophysiology of acne vulgaris depends on active sebaceous glands, implying that selective destruction of sebaceous glands could be an effective treatment. We hypothesized that light-absorbing microparticles could ...

    • An acoustic gap between the NICU and womb: a potential risk for compromised neuroplasticity of the auditory system in preterm infants 

      Lahav, Amir; Skoe, Erika (Frontiers Media S.A., 2014)
      The intrauterine environment allows the fetus to begin hearing low-frequency sounds in a protected fashion, ensuring initial optimal development of the peripheral and central auditory system. However, the auditory nursery ...

    • Acoustic Purification of Extracellular Microvesicles 

      Lee, Kyungheon; Shao, Huilin; Weissleder, Ralph; Lee, Hakho (American Chemical Society, 2015)
      Microvesicles (MVs) are an increasingly important source for biomarker discovery and clinical diagnostics. The small size of MVs and their presence in complex biological environment, however, pose technical challenges in ...

    • Acquired acrodermatitis enteropathica after gastric bypass surgery responsive to IV supplementation 

      Rana, Jasmine Kaur; Plovanich, Molly Elizabeth; Wallace, Elizabeth B; Yang, Chao Hui; Canales, Alvaro Laga; Mostaghimi, Arash (University of California, Davis, 2016)
      Nutritional deficiency is rare in developed countries, but can be acquired from decreased nutrient intake, reduced absorption, and increased gastrointestinal excretion. We report a patient with acquired acrodermatitis ...

    • Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants 

      Odone, Anna; Calderon, Roger; Becerra, Mercedes C.; Zhang, Zibiao; Contreras, Carmen C.; Yataco, Rosa; Galea, Jerome; Lecca, Leonid; Bonds, Matthew H.; Mitnick, Carole D.; Murray, Megan B. (Public Library of Science, 2016)
      Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different ...

    • Acquired MET Expression Confers Resistance to EGFR Inhibition In a Mouse Model of Glioblastoma Multiforme 

      Jun, Hyun Jung; Acquaviva, Jaime; Chi, Dorcas; Lessard, Julie; Zhu, Haihao; Woolfenden, Steve; Bronson, Roderick T.; Pfannl, Rolf; White, Forest; Housman, David E.; Iyer, Lakshmanan; Whittaker, Charles A.; Boskovitz, Abraham; Raval, Ami; Charest, Alain (2013)
      Glioblastoma Multiforme (GBM) is an aggressive brain tumor for which there is no cure. Overexpression of wild-type EGFR and loss of the tumor suppressor genes Ink4a/Arf and PTEN are salient features of this deadly cancer. ...

    • Across-cohort QC analyses of GWAS summary statistics from complex traits 

      Chen, Guo-Bo; Lee, Sang Hong; Robinson, Matthew R; Trzaskowski, Maciej; Zhu, Zhi-Xiang; Winkler, Thomas W; Day, Felix R; Croteau-Chonka, Damien C; Wood, Andrew R; Locke, Adam E; Kutalik, Zoltán; Loos, Ruth J F; Frayling, Timothy M; Hirschhorn, Joel N; Yang, Jian; Wray, Naomi R; Visscher, Peter M (Nature Publishing Group, 2017)
      Genome-wide association studies (GWASs) have been successful in discovering SNP trait associations for many quantitative traits and common diseases. Typically, the effect sizes of SNP alleles are very small and this requires ...

    • Actin Binding Domains Direct Actin-Binding Proteins to Different Cytoskeletal Locations 

      Washington, Raymond William; Knecht, David A (BioMed Central, 2008)
      Background: Filamin (FLN) and non-muscle α-actinin are members of a family of F-actin cross-linking proteins that utilize Calponin Homology domains (CH-domain) for actin binding. Although these two proteins have been ...

    • Actin Disassembly by Cofilin, Coronin, and Aip1 Occurs in Bursts and Is Inhibited by Barbed-end Cappers 

      Kueh, Hao Yuan; Charras, Guillaume T.; Mitchison, Timothy J.; Brieher, William M. (The Rockefeller University Press, 2008)
      Turnover of actin filaments in cells requires rapid actin disassembly in a cytoplasmic environment that thermodynamically favors assembly because of high concentrations of polymerizable monomers. We here image the disassembly ...

    • Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway 

      Kumari, Sudha; Depoil, David; Martinelli, Roberta; Judokusumo, Edward; Carmona, Guillaume; Gertler, Frank B; Kam, Lance C; Carman, Christopher V; Burkhardt, Janis K; Irvine, Darrell J; Dustin, Michael L (eLife Sciences Publications, Ltd, 2015)
      Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway ...

    • Actin polymerization stabilizes α4β1 integrin anchors that mediate monocyte adhesion 

      Rullo, Jacob; Becker, Henry; Hyduk, Sharon J.; Wong, Janice C.; Digby, Genevieve; Arora, Pamma D.; Cano, Adrianet Puig; Hartwig, John Henry; McCulloch, Christopher A.; Cybulsky, Myron I. (The Rockefeller University Press, 2012)
      Leukocytes arrested on inflamed endothelium via integrins are subjected to force imparted by flowing blood. How leukocytes respond to this force and resist detachment is poorly understood. Live-cell imaging with ...

    • An Actin-Based Wave Generator Organizes Cell Motility 

      Weiner, Orion D; Marganski, William A; Wu, Lani F; Altschuler, Steven J; Kirschner, Marc W. (Public Library of Science, 2007)
      Although many of the regulators of actin assembly are known, we do not understand how these components act together to organize cell shape and movement. To address this question, we analyzed the spatial dynamics of a key ...

    • Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function 

      Pacak, Christina A.; Preble, Janine M.; Kondo, Hiroshi; Seibel, Peter; Levitsky, Sidney; del Nido, Pedro J.; Cowan, Douglas B.; McCully, James D. (The Company of Biologists, 2015)
      Previously, we have demonstrated that the transplantation of viable, structurally intact, respiration competent mitochondria into the ischemic myocardium during early reperfusion significantly enhanced cardioprotection by ...

    • Actinobacillus actinomycetemcomitans Keratitis After Glaucoma Infiltration Surgery: A Clinical Report and Literature Review 

      Hong, Jiaxu; Xu, Jianjiang; Cao, Wenjun; Ji, Jian; Sun, Xinghuai (Wolters Kluwer Health, 2016)
      Abstract Actinobacillus actinomycetemcomitans infection is a rare and easily misdiagnosed ocular disease. In this article, the authors report a chronic, purulent, and difficult-to-treat case of A actinomycetemcomitans ...

    • Action Initiation in the Human Dorsal Anterior Cingulate Cortex 

      Srinivasan, Lakshminarayan; Asaad, Wael F.; Ginat, Daniel T; Gale, John T.; Dougherty, Darin Dean; Williams, Ziv; Sejnowski, Terrence J.; Eskandar, Emad (Public Library of Science, 2013)
      The dorsal anterior cingulate cortex (dACC) has previously been implicated in processes that influence action initiation. In humans however, there has been little direct evidence connecting dACC to the temporal onset of ...

    • Action video game play and transfer of navigation and spatial cognition skills in adolescents who are blind 

      Connors, Erin C.; Chrastil, Elizabeth R.; Sánchez, Jaime; Merabet, Lotfi B. (Frontiers Media S.A., 2014)
      For individuals who are blind, navigating independently in an unfamiliar environment represents a considerable challenge. Inspired by the rising popularity of video games, we have developed a novel approach to train ...