Browsing HMS Scholarly Articles by Title

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    • Citicoline Treatment Improves Measures of Impulsivity and Task Performance in Chronic Marijuana Smokers: A Pilot BOLD fMRI Study 

      Gruber, Staci A.; Sagar, Kelly A.; Dahlgren, Mary Kathryn; Gonenç, Atilla; Conn, Nina A.; Winer, Jeffrey P.; Penetar, David; Lukas, Scott E. (2015)
      Objective: Citicoline is an endogenous nucleotide that has historically been used to treat stroke, traumatic brain injury, and cognitive dysfunction. Research has also shown that citicoline treatment is associated with ...

    • Citrus Fruit Intake Substantially Reduces the Risk of Esophageal Cancer: A Meta-Analysis of Epidemiologic Studies 

      Wang, Anqiang; Zhu, Chengpei; Fu, Lilan; Wan, Xueshuai; Yang, Xiaobo; Zhang, Haohai; Miao, Ruoyu; He, Lian; Sang, Xinting; Zhao, Haitao (Wolters Kluwer Health, 2015)
      Abstract Many epidemiologic studies indicate a potential association between fruit and vegetable intake and various cancers. The purpose of this meta-analysis is to investigate the association between citrus fruit intake ...

    • CK1\(\varepsilon\) is Required for Breast Cancers Dependent on \(\beta\)-Catenin Activity 

      Firestein, Ron; Gupta, Piyush; Repich, Kara; Silver, Serena J.; Boehm, Jesse S.; Kim, So Young; Dunn, Ian Frederick; Wardwell, Leslie; Schinzel, Anna; Wittner, Ben; Root, David E.; Ramaswamy, Sridhar; Lander, Eric Steven; Hahn, William C. (Public Library of Science, 2010)
      Background: Aberrant \(\beta\)-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate \(\beta\)-catenin activity for therapeutic purposes have ...

    • CKA, a Novel Multidomain Protein, Regulates the JUN N-Terminal Kinase Signal Transduction Pathway in Drosophila 

      Chen, Hua-Wei; Marinissen, Maria Julia; Oh, Su-Wan; Chen, Xiu; Melnick, Michael; Perrimon, Norbert; Gutkind, J. Silvio; Hou, Steven X. (American Society for Microbiology, 2002)
      The Drosophila melanogaster JUN N-terminal kinase (DJNK) and DPP (decapentaplegic) signal transduction pathways coordinately regulate epithelial cell sheet movement during the process of dorsal closure in the embryo. By a ...

    • Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence 

      Rao, Vasudev R; Neogi, Ujjwal; Talboom, Joshua S; Padilla, Ligia; Rahman, Mustafizur; Fritz-French, Cari; Gonzalez-Ramirez, Sandra; Verma, Anjali; Wood, Charles; Ruprecht, Ruth M; Ranga, Udaykumar; Azim, Tasnim; Joska, John; Eugenin, Eliseo; Shet, Anita; Bimonte-Nelson, Heather; Tyor, William R; Prasad, Vinayaka R (BioMed Central, 2013)
      Background: HIV-1 Clade C (Subtype C; HIV-1C) is responsible for greater than 50% of infections worldwide. Unlike clade B HIV-1 (Subtype B; HIV-1B), which is known to cause HIV associated dementia (HAD) in approximately ...

    • Clarifying the Origin of Biological Abnormalities in PTSD Through the Study of Identical Twins Discordant for Combat Exposure 

      Pitman, roger Keith; Gilbertson, Mark; Gurvits, Tamara; May, Flavia S.; Lasko, Natasha B.; Metzger, Linda J; Shenton, Martha Elizabeth; Yehuda, Rachel; Orr, Scott P. (Wiley-Blackwell, 2006)
      A biological abnormality found to be associated with post-traumatic stress disorder (PTSD) may be, among other things, a pre-trauma vulnerability factor, that is, it may have been present prior to the event’s occurrence ...

    • Class I HDAC imaging using [3H]CI-994 autoradiography 

      Wang, Yajie; Zhang, Yan-Ling; Hennig, Krista; Gale, Jennifer P.; Hong, Yijia; Cha, Anna; Riley, Misha; Wagner, Florence; Haggarty, Stephen John; Holson, Edward; Hooker, Jacob M (Landes Bioscience, 2013)
      [3H]CI-994, a radioactive isotopologue of the benzamide CI-994, a class I histone deacetylase inhibitor (HDACi), was evaluated as an autoradiography probe for ex vivo labeling and localizing of class I HDAC (isoforms 1–3) ...

    • Class I HDAC Inhibition Blocks Cocaine-Induced Plasticity Through Targeted Changes in Histone Methylation 

      Kennedy, Pamela J.; Feng, Jian; Robison, A.J.; Maze, Ian; Badimon, Ana; Mouzon, Ezekiell; Chaudhury, Dipesh; Damez-Werno, Diane M.; Haggarty, Stephen J.; Han, Ming-Hu; Bassel-Duby, Rhonda; Olson, Eric N.; Nestler, Eric J. (2013)
      Induction of histone acetylation in the nucleus accumbens (NAc), a key brain reward region, promotes cocaine-induced alterations in gene expression. Histone deacetylases (HDACs) tightly regulate the acetylation of histone ...

    • Class II Integrase Mutants with Changes in Putative Nuclear Localization Signals Are Primarily Blocked at a Postnuclear Entry Step of Human Immunodeficiency Virus Type 1 Replication 

      Lu, Richard; Limón, Ana; Devroe, Eric; Silver, Pamela A.; Cherepanov, Peter; Engelman, Alan (American Society for Microbiology, 2004)
      Integrase has been implicated in human immunodeficiency virus type 1 (HIV-1) nuclear import. Integrase analyses, however, can be complicated by the pleiotropic nature of mutations: whereas class I mutants are integration ...

    • Class II MHC Self-Antigen Presentation in Human B and T Lymphocytes 

      Costantino, Cristina Maria; Spooner, Eric; Ploegh, Hidde L.; Hafler, David A. (Public Library of Science, 2012)
      Human CD4\(^+\) T cells process and present functional class II MHC-peptide complexes, but the endogenous peptide repertoire of these non-classical antigen presenting cells remains unknown. We eluted and sequenced HLA-DR-bound ...

    • Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma 

      Kikuchi, Shohei; Suzuki, Rikio; Ohguchi, Hiroto; Yoshida, Yashiro; Lu, Duo; Cottini, Francesca; Jakubikova, Jana; Bianchi, Giada; Harada, Takeshi; Gorgun, Guliu; Tai, Yu-Tzu; Richardson, Paul Gerard Guy; Hideshima, Teru; Anderson, Kenneth Carl (Springer Science and Business Media LLC, 2015-03-24)
      Histone deacetylase (HDAC) inhibitors have been extensively investigated as therapeutic agents in cancer. However, the biologic role of class IIa HDACs (HDAC4, 5, 7 and 9) in cancer cells, including multiple myeloma (MM), ...

    • Classical Conditioned Responses to Absent Tones 

      Bangert, Marc; Jürgens, Uwe; Häusler, Udo; Altenmüller, Eckart (BioMed Central, 2006)
      Background: Recent evidence for a tight coupling of sensorimotor processes in trained musicians led to the question of whether this coupling extends to preattentively mediated reflexes; particularly, whether a classically ...

    • Classical Flt3L-dependent dendritic cells control immunity to protein vaccine 

      Anandasabapathy, Niroshana; Feder, Rachel; Mollah, Shamim; Tse, Sze-Wah; Longhi, Maria Paula; Mehandru, Saurabh; Matos, Ines; Cheong, Cheolho; Ruane, Darren; Brane, Lucas; Teixeira, Angela; Dobrin, Joseph; Mizenina, Olga; Park, Chae Gyu; Meredith, Matthew; Clausen, Björn E.; Nussenzweig, Michel C.; Steinman, Ralph M. (The Rockefeller University Press, 2014)
      DCs are critical for initiating immunity. The current paradigm in vaccine biology is that DCs migrating from peripheral tissue and classical lymphoid-resident DCs (cDCs) cooperate in the draining LNs to initiate priming ...

    • Classical pathology and mutational load of breast cancer – integration of two worlds 

      Budczies, Jan; Bockmayr, Michael; Denkert, Carsten; Klauschen, Frederick; Lennerz, Jochen K; Györffy, Balázs; Dietel, Manfred; Loibl, Sibylle; Weichert, Wilko; Stenzinger, Albrecht (John Wiley and Sons Inc., 2015)
      Abstract Breast cancer is a complex molecular disease comprising several biological subtypes. However, daily routine diagnosis is still based on a small set of well‐characterized clinico‐pathological variables. Here, we ...

    • The Classical Pink-Eyed Dilution Mutation Affects Angiogenic Responsiveness 

      Rogers, Michael S.; Boyartchuk, Victor; Rohan, Richard M.; Birsner, Amy E.; Dietrich, William F.; D’Amato, Robert J. (Public Library of Science, 2012)
      Angiogenesis is the process by which new blood vessels are formed from existing vessels. Mammalian populations, including humans and mice, harbor genetic variations that alter angiogenesis. Angiogenesis-regulating gene ...

    • Classification of Human Coronary Atherosclerotic Plaques with T1, T2 and Ultrashort TE MRI 

      Karolyi, Mihaly; Seifarth, Harald Dirk; Liew, Gary; Schlett, Christopher L; Maurovich-Horvat, Pal; Dai, Guangping; Huang, Shuning; Goergen, Craig J; Hoffmann, Udo; Sosnovik, David E. (BioMed Central, 2012)
      Multicontrast MRI with T1, T2 and Ultrashort TE (UTE) sequences is used to image atherosclerotic plaque in human coronary arteries. MRI classification of the plaques is compared with their histological classification and ...

    • Classify Hyperdiploidy Status of Multiple Myeloma Patients Using Gene Expression Profiles 

      Li, Yingxiang; Wang, Xujun; Zheng, Haiyang; Wang, Chengyang; Minvielle, Stéphane; Magrangeas, Florence; Avet-Loiseau, Hervé; Shah, Parantu K.; Zhang, Yong; Munshi, Nikhil C; Li, Cheng (Public Library of Science, 2013)
      Multiple myeloma (MM) is a cancer of antibody-making plasma cells. It frequently harbors alterations in DNA and chromosome copy numbers, and can be divided into two major subtypes, hyperdiploid (HMM) and non-hyperdiploid ...

    • Classroom to Clinic: Merging Education and Research to Efficiently Prototype Medical Devices 

      Hanumara, Nevan C.; Begg, Nikolai D.; Walsh, Conor; Custer, David; Gupta, Rajiv; Osborn, Lynn R.; Slocum, Alexander H. (IEEE, 2013)
      Innovation in patient care requires both clinical and technical skills, and this paper presents the methods and outcomes of a nine-year, clinical-academic collaboration to develop and evaluate new medical device technologies, ...

    • Claudin-2-dependent paracellular channels are dynamically gated 

      Weber, Christopher R; Liang, Guo Hua; Wang, Yitang; Das, Sudipto; Shen, Le; Yu, Alan S L; Nelson, Deborah J; Turner, Jerrold R (eLife Sciences Publications, Ltd, 2015)
      Intercellular tight junctions form selectively permeable barriers that seal the paracellular space. Trans-tight junction flux has been measured across large epithelial surfaces, but conductance across individual channels ...

    • Claudin-8 Expression in Madin-Darby Canine Kidney Cells Augments the Paracellular Barrier to Cation Permeation 

      Yu, Alan S. L.; Enck, Alissa H.; Lencer, Wayne I.; Schneeberger, Eveline E. (American Society for Biochemistry and Molecular Biology, 2003)
      Claudins are a family of integral membrane proteins of the tight junction that are thought to participate in the permeation of solutes across epithelia via the paracellular pathway. Claudin-8 is expressed in the distal ...