Browsing HMS Scholarly Articles by Title
Now showing items 2817-2836 of 17922
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Cocaine Enhances DC to T-cell HIV-1 Transmission by Activating DC-SIGN/LARG/LSP1 Complex and Facilitating Infectious Synapse Formation
(Nature Publishing Group, 2017)DC-SIGN is a dendritic cell surface structure which participates in binding and transmission of HIV-1. Here, for the first time we demonstrate that cocaine induces over expression of DC-SIGN and significantly enhances virus ... -
Cocaine enhances HIV-1 gp120-induced lymphatic endothelial dysfunction in the lung
(John Wiley & Sons, Ltd, 2015)Pulmonary complications are common in both AIDS patients and cocaine users. We addressed the cellular and molecular mechanisms by which HIV and cocaine may partner to induce their deleterious effects. Using primary lung ... -
Cocaine-conditioned odor cues without chronic exposure: Implications for the development of addiction vulnerability
(Elsevier, 2015)Adolescents are highly vulnerable to addiction and are four times more likely to become addicted at first exposure than at any other age. The dopamine D1 receptor, which is typically overexpressed in the normal adolescent ... -
Cochlear neuropathy and the coding of supra-threshold sound
(Frontiers Media S.A., 2014)Many listeners with hearing thresholds within the clinically normal range nonetheless complain of difficulty hearing in everyday settings and understanding speech in noise. Converging evidence from human and animal studies ... -
Cockayne Syndrome Protein B Interacts with and Is Phosphorylated by c-Abl Tyrosine Kinase
(Oxford University Press, 2007)The Cockayne Syndrome group B (CSB) protein plays important roles in transcription, transcription-coupled nucleotide excision repair and base excision DNA repair. c-Abl kinase also plays a role in DNA repair as a ... -
Codifying Collegiality: Recent Developments in Data Sharing Policy in the Life Sciences
(Public Library of Science, 2014)Over the last decade, there have been significant changes in data sharing policies and in the data sharing environment faced by life science researchers. Using data from a 2013 survey of over 1600 life science researchers, ... -
Codifying healthcare – big data and the issue of misclassification
(BioMed Central, 2015)The rise of electronic medical records has led to a proliferation of large observational studies that examine the perioperative period. In contrast to randomized controlled trials, these studies have the ability to provide ... -
Codon-Optimized Gaussia Luciferase cDNA for Mammalian Gene Expression in Culture and in Vivo
(Elsevier (Cell Press), 2005)Photoproteins have played a major role in advancing our understanding of biological processes. A broader array of biocompatible, nontoxic, and novel reporters can serve to expand this potential. Here we describe the ... -
Coevolution of interacting proteins through non-contacting and non-specific mutations
(Cold Spring Harbor Laboratory, 2021-10-08)<jats:title>Summary</jats:title><jats:p>Proteins often accumulate neutral mutations that do not affect current functions<jats:sup>1</jats:sup> but can profoundly influence future mutational possibilities and functions<ja ... -
Coexistence of Histologically Confirmed Hashimoto's Thyroiditis with Different Stages of Papillary Thyroid Carcinoma in a Consecutive Chinese Cohort
(Hindawi Publishing Corporation, 2014)Purpose. To determine the relationship between Hashimoto's thyroiditis (HT) and all stages of papillary thyroid carcinoma (PTC) with or without local lymph node metastasis (LNM). Methods:. We conducted a retrospective study ... -
Coexistent Types of Atrioventricular Nodal Re-Entrant Tachycardia: Implications for the Tachycardia Circuit
(Lippincott Williams & Wilkins, 2015)Background— There is evidence that atypical fast–slow and typical atrioventricular nodal re-entrant tachycardia (AVNRT) do not use the same limb for fast conduction, but no data exist on patients who have presented with ... -
Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance.
(American Society for Clinical Investigation, 1990)The present studies investigated the expression of the two PDGF genes (c-sis/PDGF-2 and PDGF-1) and the PDGF-receptor b gene (PDGF-R) in 34 primary human astrocytomas. Northern blot analysis demonstrated the coexpression ... -
Coffee and Caffeine Consumption in Relation to Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Postmenopausal Women
(American Diabetes Association, 2011)OBJECTIVE: Coffee consumption has been inversely associated with type 2 diabetes risk, but its mechanisms are largely unknown. We aimed to examine whether plasma levels of sex hormones and sex hormone–binding globulin ... -
Coffee and cancer risk: A meta-analysis of prospective observational studies
(Nature Publishing Group, 2016)Meta-analyses on coffee and cancer incidence mainly restricted to limited cancers. We carried out a more comprehensive meta-analysis of cohort studies to explore association between coffee and most cancer types. We conducted ... -
Coffee Consumption and Risk of Cardiovascular Diseases and All-Cause Mortality Among Men With Type 2 Diabetes
(American Diabetes Association, 2009)OBJECTIVE: Coffee consumption has been linked to detrimental acute metabolic and hemodynamic effects. We investigated coffee consumption in relation to risk of CVDs and mortality in diabetic men. RESEARCH DESIGN AND METHODS: ... -
Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer
(Springer Science + Business Media, 2008)We evaluated whether genetic variability, as well as menopausal status, modify the association between coffee intake and risk of ovarian cancer. Risk factor information and biologic specimens from three large epidemiological ... -
Cognitive and Brain Reserve and the Risk of Postoperative Delirium in Older Patients: Analysis of Data From a Prospective Observational Study
(Elsevier BV, 2014-11-01)Background Cognitive and brain reserve theories suggest that aspects of neural architecture or cognitive processes modify the impact of neuropathological processes on cognitive outcomes. While frequently studied in the ... -
Cognitive and Other Adverse Effects of Diphenhydramine Use in Hospitalized Older Patients
(American Medical Association (AMA), 2001) -
Cognitive and Physical Demands of Activities of Daily Living In Older Adults: Validation of Expert Panel Ratings: The SAGES Functional Measures Working Group
(2015)Background: Difficulties with performance of functional activities may result from cognitive and/or physical impairments. To date, there has not been a clear delineation of the physical and cognitive demands of activities ... -
Cognitive changes associated with switching to frequent nocturnal hemodialysis or renal transplantation
(BioMed Central, 2016)Background: It is uncertain whether switching to frequent nocturnal hemodialysis improves cognitive function in well-dialyzed patients and how this compares to patients who receive a kidney transplant. Methods: We conducted ...