Now showing items 2854-2873 of 17918

    • Cold Blockade of Axonal Transport Activates Premitotic Activity of Schwann Cells and Wallerian Degeneration 

      Oaklander, Anne Louise; Spencer, Peter S. (Wiley, 1988)
      Between 3 and 4 days after transection of cat sciatic nerve, Schwann cell-associated premitotic activity spreads anterogradely along degenerating distal nerve stumps at a rate of approximately 200 mm/day. We inves- tigated ...
    • The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue 

      Lynes, Matthew David; Leiria, Luiz; Lundh, Morten; Bartelt, Alexander; Shamsi, Farnaz; Huang, Tianwen; Takahashi, Hirokazu; Hirshman, Michael F; Schlein, Christian; Lee, Alexandra; Baer, Lisa A; May, Francis J; Gao, Fei; Narain, Niven R; Chen, Emily Y; Kiebish, Michael A; Cypess, Aaron; Blüher, Matthias; Goodyear, Laurie Joy; Hotamisligil, Gokhan S.; Stanford, Kristin I; Tseng, Yu-Hua (Springer Nature, 2017)
      Brown adipose tissue (BAT) and beige adipose tissue combust fuels for heat production in adult humans, and so constitute an appealing target for the treatment of metabolic disorders such as obesity, diabetes and ...
    • COLD-PCR Amplification of Bisulfite-Converted DNA Allows the Enrichment and Sequencing of Rare Un-Methylated Genomic Regions 

      Castellanos-Rizaldos, Elena; Milbury, Coren A.; Karatza, Elli; Chen, Clark C.; Makrigiorgos, G. Mike; Merewood, Anne (Public Library of Science, 2014)
      Aberrant hypo-methylation of DNA is evident in a range of human diseases including cancer and diabetes. Development of sensitive assays capable of detecting traces of un-methylated DNA within methylated samples can be ...
    • Collaborating to Move Research Forward: Proceedings of the 10th Annual Bladder Cancer Think Tank 

      Kamat, Ashish M.; Agarwal, Piyush; Bivalacqua, Trinity; Chisolm, Stephanie; Daneshmand, Sia; Doroshow, James H.; Efstathiou, Jason A.; Galsky, Matthew; Iyer, Gopa; Kassouf, Wassim; Shah, Jay; Taylor, John; Williams, Stephen B.; Quale, Diane Zipursky; Rosenberg, Jonathan E. (IOS Press, 2016)
      The 10th Annual Bladder Cancer Think Tank was hosted by the Bladder Cancer Advocacy Network and brought together a multidisciplinary group of clinicians, researchers, representatives and Industry to advance bladder cancer ...
    • Collaboration gets the most out of software 

      Morin, Andrew; Eisenbraun, Ben; Key, Jason; Sanschagrin, Paul C; Timony, Michael A; Ottaviano, Michelle; Sliz, Piotr (eLife Sciences Publications, Ltd, 2013)
      By centralizing many of the tasks associated with the upkeep of scientific software, SBGrid allows researchers to spend more of their time on research.
    • Collagen Type IV and Laminin Expressions during Cartilage Repair and in Late Clinically Failed Repair Tissues from Human Subjects 

      Foldager, Casper Bindzus; Toh, Wei Seong; Christensen, Bjørn Borsøe; Lind, Martin; Gomoll, Andreas H.; Spector, Myron (SAGE Publications, 2015)
      Objective: To identify the collagen type IV (Col4) isoform in articular cartilage and to evaluate the expressions of Col4 and laminin in the pericellular matrix (PCM) in damaged cartilage and during cartilage repair. Design: ...
    • Collagen XXIII: A Potential Biomarker for the Detection of Primary and Recurrent Non–Small Cell Lung Cancer 

      Spivey, Kristin A.; Banyard, Jacqueline; Solis, Luisa M.; Wistuba, Ignacio I.; Barletta, Justine; Gandhi, Leena; Feldman, Henry; Rodig, Scott; Chirieac, Lucian; Zetter, Bruce (American Association for Cancer Research (AACR), 2010-05)
      Background Collagen XXIII is a transmembrane collagen previously shown to be upregulated in metastatic prostate cancer. This study’s purpose was to determine the protein expression of collagen XXIII in tumor tissues from ...
    • Collection of Bilateral Cleft Lip and Palate Standard Set Variables 

      Citron, Isabelle; Ganske, Ingrid; Massenburg, Benjamin B.; Doyle, Michael; Meara, John; Rogers-Vizena, Carolyn R. (Ovid Technologies (Wolters Kluwer Health), 2018-08-16)
      Background: The International Consortium for Healthcare Outcomes Measurement recently published a consensus Standard Set of clinical and patient-centered metrics to measure outcomes for patients with cleft lip and/or palate ...
    • Collective and Individual Migration following the Epithelial-Mesenchymal Transition 

      Wong, Ian Y.; Javaid, Sarah; Wong, Elisabeth A.; Perk, Sinem; Haber, Daniel A.; Toner, Mehmet; Irimia, Daniel (2014)
      During cancer progression, malignant cells in the tumour invade surrounding tissues. This transformation of adherent cells to a motile phenotype has been associated with the epithelial mesenchymal transition (EMT). Here, ...
    • Collective Epithelial Migration Drives Kidney Repair after Acute Injury 

      Palmyre, Aurélien; Lee, Jeongeun; Ryklin, Gennadiy; Camarata, Troy; Selig, Martin K.; Duchemin, Anne-Laure; Nowak, Paul; Arnaout, M. Amin; Drummond, Iain A.; Vasilyev, Aleksandr (Public Library of Science, 2014)
      Acute kidney injury (AKI) is a common and significant medical problem. Despite the kidney’s remarkable regenerative capacity, the mortality rate for the AKI patients is high. Thus, there remains a need to better understand ...
    • Colocalization of 14-3-3 Proteins with SOD1 in Lewy Body-Like Hyaline Inclusions in Familial Amyotrophic Lateral Sclerosis Cases and the Animal Model 

      Okamoto, Yoko; Shirakashi, Yoshitomo; Ihara, Masafumi; Urushitani, Makoto; Oono, Miki; Kawamoto, Yasuhiro; Yamashita, Hirofumi; Shimohama, Shun; Kato, Shinsuke; Hirano, Asao; Tomimoto, Hidekazu; Ito, Hidefumi; Takahashi, Ryosuke; Feany, Mel B. (Public Library of Science, 2011)
      Background and Purpose: Cu/Zn superoxide dismutase (SOD1) is a major component of Lewy body-like hyaline inclusion (LBHI) found in the postmortem tissue of SOD1-linked familial amyotrophic lateral sclerosis (FALS) patients. ...
    • Colocalized Structural and Functional Changes in the Cortex of Patients with Trigeminal Neuropathic Pain 

      DaSilva, Alexandre F.; Becerra, Lino Renan; Pendse, Gautam; Chizh, Boris; Tully, Shannon; Borsook, David (Public Library of Science, 2008)
      Background: Recent data suggests that in chronic pain there are changes in gray matter consistent with decreased brain volume, indicating that the disease process may produce morphological changes in the brains of those ...
    • Colon cancer surgery following emergency presentation: effects on admission and stage-adjusted outcomes. 

      Amri, Ramzi; Bordeianou, Liliana Grigorievna; Sylla, Patricia; Berger, David Lawrence (Elsevier, 2015)
      Background: Emergency presentation with colon cancer is intuitively related to advanced disease. We measured its effect on outcomes of surgically treated colon cancer. Methods: A retrospective cohort of 1,071 surgical ...
    • Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab 

      Cho, Jeonghee; Bass, Adam J; Lawrence, Michael S; Cibulskis, Kristian; Cho, Ahye; Lee, Shi-Nai; Yamauchi, Mai; Wagle, Nikhil; Pochanard, Panisa; Kim, Nayoung; Park, Angela KJ; Won, Jonghwa; Hur, Hyung-Suk; Greulich, Heidi; Ogino, Shuji; Sougnez, Carrie; Voet, Douglas; Tabernero, Josep; Jimenez, Jose; Baselga, Jose; Gabriel, Stacey B; Lander, Eric S; Getz, Gad; Eck, Michael J; Park, Woong-Yang; Meyerson, Matthew (BioMed Central, 2014)
      Background: Inhibition of the activated epidermal growth factor receptor (EGFR) with either enzymatic kinase inhibitors or anti-EGFR antibodies such as cetuximab, is an effective modality of treatment for multiple human ...
    • Colonic Patch and colonic SILT development are independent and differentially-regulated events 

      Baptista, AP; Olivier, BJ; Goverse, G; Greuter, M; Knippenberg, M; Kusser, K; Domingues, RG.; Veiga-Fernandes, H; Luster, AD; Lugering, A; Randall, TD; Cupedo, T; Mebius, RE (2012)
      Intestinal lymphoid tissues have to simultaneously ensure protection against pathogens and tolerance towards commensals. Despite such vital functions, their development in the colon is poorly understood. Here, we show that ...
    • Colonization with Antibiotic-Susceptible Strains Protects against Methicillin-Resistant Staphylococcus aureus but not Vancomycin-Resistant Enterococci Acquisition: A Nested Case-Control Study 

      Huang, Susan Shih; Datta, Rupak; Rifas-Shiman, Sheryl Lynn; Kleinman, Ken Paul; Placzek, Hilary; Lankiewicz, Julie D.; Platt, Richard (BioMed Central, 2011)
      Introduction: Harboring sensitive strains may prevent acquisition of resistant pathogens by competing for colonization of ecological niches. Competition may be relevant to decolonization strategies that eliminate sensitive ...
    • Color Standardization and Optimization in Whole Slide Imaging 

      Yagi, Yukako (BioMed Central, 2011)
      Introduction: Standardization and validation of the color displayed by digital slides is an important aspect of digital pathology implementation. While the most common reason for color variation is the variance in the ...
    • Colorectal Cancers from Distinct Ancestral Populations Show Variations in BRAF Mutation Frequency 

      Hanna, Megan C.; Go, Christina; Roden, Christine; Jones, Robert T.; Pochanard, Panisa; Javed, Ahmed Yasir; Javed, Awais; Mondal, Chandrani; Palescandolo, Emanuele; Van Hummelen, Paul; Hatton, Charles; Bass, Adam J.; Chun, Sung Min; Na, Deuk Chae; Kim, Tae-Im; Jang, Se Jin; Osarogiagbon, Raymond U.; Hahn, William C.; Meyerson, Matthew; Garraway, Levi A.; MacConaill, Laura E. (Public Library of Science, 2013)
      It has been demonstrated for some cancers that the frequency of somatic oncogenic mutations may vary in ancestral populations. To determine whether key driver alterations might occur at different frequencies in colorectal ...
    • Colorimetric and Longitudinal Analysis of Leukocoria in Recreational Photographs of Children with Retinoblastoma 

      Abdolvahabi, Alireza; Taylor, Brandon W.; Holden, Rebecca L.; Shaw, Elizabeth V.; Kentsis, Alex; Rodriguez-Galindo, Carlos; Mukai, Shizuo; Shaw, Bryan F. (Public Library of Science, 2013)
      Retinoblastoma is the most common primary intraocular tumor in children. The first sign that is often reported by parents is the appearance of recurrent leukocoria (i.e., “white eye”) in recreational photographs. A ...
    • Columnar Cell Lesions and Subsequent Breast Cancer Risk: A Nested Case-Control Study 

      Aroner, Sarah A.; Collins, Laura Christine; Schnitt, Stuart Jay; Connolly, James Leo; Colditz, Graham A.; Tamimi, Rulla May (BioMed Central, 2010)
      Introduction: Histologic and genetic evidence suggests that at least some columnar cell lesions (CCL) of the breast represent precursor lesions in the low-grade breast neoplasia pathway. However, the risk of subsequent ...