Browsing HMS Scholarly Articles by Title
Now showing items 2959-2978 of 17918
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Common variant rs356182 near SNCA defines a Parkinson's disease endophenotype
(John Wiley and Sons Inc., 2016)Abstract Objective: Parkinson's disease (PD) presents clinically with several motor subtypes that exhibit variable treatment response and prognosis. Here, we investigated genetic variants for their potential association ... -
Common variants associated with plasma triglycerides and risk for coronary artery disease
(2013)Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiologic studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear ... -
Common Variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 Are Associated with Breast Cancer Risk for BRCA1 and/or BRCA2 Mutation Carriers
(BioMed Central, 2012)Introduction: Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified ... -
Common variants at 12q14 and 12q24 are associated with hippocampal volume
(2012)Aging is associated with reductions in hippocampal volume (HV) that are accelerated by Alzheimer’s disease and vascular risk factors. Our genome-wide association study of dementia-free persons (n=9,232) identified 46 SNPs ... -
Common variants at 19p13 are associated with susceptibility to ovarian cancer
(Nature Publishing Group, 2010)Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world accounting for 4 percent of deaths from cancer in women1. We performed a three-phase genome-wide association ... -
Common Variants at 9p21 and 8q22 Are Associated with Increased Susceptibility to Optic Nerve Degeneration in Glaucoma
(Public Library of Science, 2012)Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide. Patients affected by the normal-pressure form of glaucoma are more likely to harbor risk alleles for glaucoma-related optic nerve ... -
Common variants at theCHEK2gene locus and risk of epithelial ovarian cancer
(Oxford University Press (OUP), 2015)Genome-wide association studies have identified 20 genomic regions associated with risk of epithelial ovarian cancer (EOC), but many additional risk variants may exist. Here, we evaluated associations between common genetic ... -
Common Variants in 40 Genes Assessed for Diabetes Incidence and Response to Metformin and Lifestyle Intervention in the Diabetes Prevention Program
(American Diabetes Association, 2010)OBJECTIVE: Genome-wide association studies have begun to elucidate the genetic architecture of type 2 diabetes. We examined whether single nucleotide polymorphisms (SNPs) identified through targeted complementary approaches ... -
Common Variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE Genes Are Associated With Type 2 Diabetes and Impaired Fasting Glucose in a Chinese Han Population
(American Diabetes Association, 2008)OBJECTIVE— Genome-wide association studies have identified common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, HHEX/IDE, EXT2, and LOC387761 loci that significantly increase the risk of type 2 diabetes. We aimed to ... -
Common Variants in the Adiponectin Gene (ADIPOQ) Associated with Plasma Adiponectin Levels, Type 2 Diabetes, and Diabetes-Related Quantitative Traits
(American Diabetes Association, 2008)OBJECTIVE— Variants in ADIPOQ have been inconsistently associated with adiponectin levels or diabetes. Using comprehensive linkage disequilibrium mapping, we genotyped single nucleotide polymorphisms (SNPs) in ADIPOQ to ... -
Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma
(2014)Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness worldwide. We performed a genome-wide association study in an Australian discovery cohort comprising 1,155 advanced POAG cases and 1,992 controls. ... -
Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals
(Public Library of Science, 2011)Common genetic variants have been shown to explain a fraction of the inherited variation for many common diseases and quantitative traits, including height, a classic polygenic trait. The extent to which common variation ... -
The Commonality of Loss Aversion across Procedures and Stimuli
(Public Library of Science, 2015)Individuals tend to give losses approximately 2-fold the weight that they give gains. Such approximations of loss aversion (LA) are almost always measured in the stimulus domain of money, rather than objects or pictures. ... -
Communicating new knowledge on previously reported genetic variants
(Nature Publishing Group, 2012)Genetic tests often identify variants whose significance cannot be determined at the time they are reported. In many situations, it is critical that clinicians be informed when new information emerges on these variants. ... -
Communication between subunits critical to DNA binding by hexameric helicase of bacteriophage T7
(National Academy of Sciences, 2008)The DNA helicase encoded by bacteriophage T7 consists of six identical subunits that form a ring through which the DNA passes. Binding of ssDNA is a prior step to translocation and unwinding of DNA by the helicase. Arg-493 ... -
Community attitudes towards culture-influenced mental illness: scrupulosity vs. nonreligious OCD among orthodox jews
(Wiley-Blackwell, 2009)Culture may particularly influence community attitudes towards mental illness, when the illness itself is shaped by a cultural context. To explore the influence of culture-specific, religious symptoms on Orthodox Jewish ... -
Community awareness, use and preference for pandemic influenza vaccines in Pune, India
(Informa UK Limited, 2015)Vaccination is a cornerstone of influenza prevention, but limited vaccine uptake was a problem worldwide during the 2009–2010 pandemic. Community acceptance of a vaccine is a critical determinant of its effectiveness, but ... -
Community Concepts of Malaria-Related Illness With and Without Convulsions in Southern Ghana
(BMC, 2005-09-27)Background Malaria, both with or without convulsions, is a serious hardship for people living in endemic areas, especially in sub-Saharan Africa. Community references to malaria, however, may encompass other conditions, ... -
Community Cultural Norms, Stigma and Disclosure to Sexual Partners among Women Living with HIV in Thailand, Brazil and Zambia (HPTN 063)
(Public Library of Science, 2016)Background: Serostatus disclosure may facilitate decreased HIV transmission between serodiscordant partners by raising risk awareness and heightening the need for prevention. For women living with HIV (WLWH), the decision ... -
Community mental health and concepts of mental illness in the Sundarban Delta of West Bengal, India
(Informa UK Limited, 2001)The Sundarban Delta of West Bengal is a remote, rural region with poor infrastructure and until recently without designated mental health services or a community mental health programme. To inform development of such a ...