Browsing HMS Scholarly Articles by Title

Now showing items 2993-3012 of 17922

    • Comparative Analysis of Erk Phosphorylation Suggests a Mixed Strategy for Measuring Phospho-Form Distributions 

      Prabakaran, Sudhakaran; Everley, Robert A; Landrieu, Isabelle; Wieruszeski, Jean-Michel; Lippens, Guy; Steen, Hanno; Gunawardena, Jeremy H. (Nature Publishing Group, 2011)
      The functional impact of multisite protein phosphorylation can depend on both the numbers and the positions of phosphorylated sites—the global pattern of phosphorylation or ‘phospho-form’—giving biological systems profound ...

    • A comparative analysis of family-based and population-based association tests using whole genome sequence data 

      Zhou, Jin J; Yip, Wai-Ki; Cho, Michael H; Qiao, Dandi; McDonald, Merry-Lynn N; Laird, Nan M (BioMed Central, 2014)
      The revolution in next-generation sequencing has made obtaining both common and rare high-quality sequence variants across the entire genome feasible. Because researchers are now faced with the analytical challenges of ...

    • A Comparative Analysis of Genetic and Epigenetic Events of Breast and Ovarian Cancer Related to Tumorigenesis 

      Longacre, Mckenna; Snyder, Nicole A.; Housman, Genevieve; Leary, Meghan; Lapinska, Karolina; Heerboth, Sarah; Willbanks, Amber; Sarkar, Sibaji (MDPI, 2016)
      Breast cancer persists as the most common cause of cancer death in women worldwide. Ovarian cancer is also a significant source of morbidity and mortality, as the fifth leading cause of cancer death among women. This ...

    • Comparative analysis of mycobacterium and related actinomycetes yields insight into the evolution of mycobacterium tuberculosis pathogenesis 

      Weiner, Brian; Raman, Sahadevan; Dolganov, Gregory; Peterson, Matthew; Riley, Robert; Abeel, Thomas; White, Jared; Sisk, Peter; Stolte, Christian; Koehrsen, Mike; Yamamoto, Robert T; Iacobelli-Martinez, Milena; Kidd, Matthew J; Maer, Andreia M; Schoolnik, Gary K; Regev, Aviv; McGuire, Abigail Manson; Park, Sang T.; Wapinski, Ilan Neustat; Zucker, Jeremy Daniel Hofeld; Galagan, James E. (BioMed Central, 2012)
      Background: The sequence of the pathogen Mycobacterium tuberculosis (Mtb) strain H37Rv has been available for over a decade, but the biology of the pathogen remains poorly understood. Genome sequences from other Mtb strains ...

    • A Comparative Analysis of Speed Profile Models for Ankle Pointing Movements: Evidence that Lower and Upper Extremity Discrete Movements are Controlled by a Single Invariant Strategy 

      Michmizos, Konstantinos P.; Vaisman, Lev; Krebs, Hermano Igo (Frontiers Media S.A., 2014)
      Little is known about whether our knowledge of how the central nervous system controls the upper extremities (UE), can generalize, and to what extent to the lower limbs. Our continuous efforts to design the ideal adaptive ...

    • Comparative analysis of the human saliva microbiome from different climate zones: Alaska, Germany, and Africa 

      Li, Jing; Quinque, Dominique; Horz, Hans-Peter; Li, Mingkun; Rzhetskaya, Margarita; Raff, Jennifer A; Hayes, M Geoffrey; Stoneking, Mark (BioMed Central, 2014)
      Background: Although the importance of the human oral microbiome for health and disease is increasingly recognized, variation in the composition of the oral microbiome across different climates and geographic regions is ...

    • Comparative Analysis of the Transcriptome Across Distant Species 

      Gerstein, Mark B.; Rozowsky, Joel; Yan, Koon-Kiu; Wang, Daifeng; Cheng, Chao; Brown, James B.; Davis, Carrie A.; Hillier, LaDeana; Sisu, Cristina; Li, Jingyi Jessica; Pei, Baikang; Harmanci, Arif O.; Duff, Michael O.; Djebali, Sarah; Alexander, Roger P.; Alver, Burak; Auerbach, Raymond; Bell, Kimberly; Bickel, Peter J.; Boeck, Max E.; Boley, Nathan P.; Booth, Benjamin W.; Cherbas, Lucy; Cherbas, Peter; Di, Chao; Dobin, Alex; Drenkow, Jorg; Ewing, Brent; Fang, Gang; Fastuca, Megan; Feingold, Elise A.; Frankish, Adam; Gao, Guanjun; Good, Peter J.; Guigó, Roderic; Hammonds, Ann; Harrow, Jen; Hoskins, Roger A.; Howald, Cédric; Hu, Long; Huang, Haiyan; Hubbard, Tim J. P.; Huynh, Chau; Jha, Sonali; Kasper, Dionna; Kato, Masaomi; Kaufman, Thomas C.; Kitchen, Robert R.; Ladewig, Erik; Lagarde, Julien; Lai, Eric; Leng, Jing; Lu, Zhi; MacCoss, Michael; May, Gemma; McWhirter, Rebecca; Merrihew, Gennifer; Miller, David M.; Mortazavi, Ali; Murad, Rabi; Oliver, Brian; Olson, Sara; Park, Peter; Pazin, Michael J.; Perrimon, Norbert; Pervouchine, Dmitri; Reinke, Valerie; Reymond, Alexandre; Robinson, Garrett; Samsonova, Anastasia; Saunders, Gary I.; Schlesinger, Felix; Sethi, Anurag; Slack, Frank J.; Spencer, William C.; Stoiber, Marcus H.; Strasbourger, Pnina; Tanzer, Andrea; Thompson, Owen A.; Wan, Kenneth H.; Wang, Guilin; Wang, Huaien; Watkins, Kathie L.; Wen, Jiayu; Wen, Kejia; Xue, Chenghai; Yang, Li; Yip, Kevin; Zaleski, Chris; Zhang, Yan; Zheng, Henry; Brenner, Steven E.; Graveley, Brenton R.; Celniker, Susan E.; Gingeras, Thomas R.; Waterston, Robert (Springer Science and Business Media LLC, 2014-08-27)
      The transcriptome is the readout of the genome. Identifying common features in it across distant species can reveal fundamental principles. To this end, the ENCODE and modENCODE consortia have generated large amounts of ...

    • Comparative assessment of medicine procurement prices in the United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) 

      Ewen, Margaret; Al Sakit, Maisa; Saadeh, Rawan; Laing, Richard; Vialle-Valentin, Catherine; Seita, Akihiro; Bunders, Joske (BioMed Central, 2014)
      Objectives: The United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA), the main primary healthcare provider for 4.9 million Palestinian refugees, spent USD18.3 million on essential medicines ...

    • Comparative Cost-Effectiveness of Strategies to Prevent Postoperative Clinical Recurrence of Crohnʼs Disease 

      Doherty, Glen; Miksad, Rebecca A.; Cheifetz, Adam; Moss, Alan C. (Oxford University Press (OUP), 2012-09-01)
      Background A number of treatments have been shown to reduce the risk of postoperative recurrence of Crohn's disease (CD). The optimal strategy is unknown. The aim was to evaluate the comparative cost-effectiveness of ...

    • Comparative Definitions for Moderate-Severe Ischemia in Stress Nuclear, Echocardiography, and Magnetic Resonance Imaging 

      Shaw, Leslee J.; Berman, Daniel S.; Picard, Michael Howard; Friedrich, Matthias G.; Kwong, Raymond Yan-Kit; Stone, Gregg W.; Senior, Roxy; Min, James K.; Hachamovitch, Rory; Scherrer-Crosbie, Marielle; Mieres, Jennifer H.; Marwick, Thomas H.; Phillips, Lawrence M.; Chaudhry, Farooq A.; Pellikka, Patricia A.; Slomka, Piotr; Arai, Andrew E.; Iskandrian, Ami E.; Bateman, Timothy M.; Heller, Gary V.; Miller, Todd D.; Nagel, Eike; Goyal, Abhinav; Borges-Neto, Salvador; Boden, William E.; Reynolds, Harmony R.; Hochman, Judith S.; Maron, David J.; Douglas, Pamela S. (Elsevier BV, 2014)
      The lack of standardized reporting of the magnitude of ischemia on noninvasive imaging contributes to variability in translating the severity of ischemia across stress imaging modalities. We identified the risk of coronary ...

    • A Comparative Effectiveness Analysis of Three Continuous Glucose Monitors 

      Damiano, Edward R.; El-Khatib, Firas H.; Zheng, Hui; Nathan, David M.; Russell, Steven J. (American Diabetes Association, 2013)
      OBJECTIVE To compare three continuous glucose monitoring (CGM) devices in subjects with type 1 diabetes under closed-loop blood glucose (BG) control. RESEARCH DESIGN AND METHODS Six subjects with type 1 diabetes (age 52 ± ...

    • Comparative effectiveness of exercise and drug interventions on mortality outcomes: metaepidemiological study 

      Naci, Huseyin; Ioannidis, John P A (BMJ Publishing Group Ltd., 2013)
      Objective: To determine the comparative effectiveness of exercise versus drug interventions on mortality outcomes. Design: Metaepidemiological study. Eligibility criteria Meta-analyses of randomised controlled trials with ...

    • Comparative Effectiveness of Generic and Brand-Name Statins on Patient Outcomes 

      Gagne, Joshua J; Choudhry, Niteesh Kumar; Kesselheim, Aaron Seth; Polinski, Jennifer Milan; Hutchins, David; Matlin, Olga S.; Brennan, Troyen Anthony; Avorn, Jerry Lewis; Shrank, William (American College of Physicians, 2014)
      Background: Statins are effective in preventing cardiovascular events, but patients do not fully adhere to them. Objective: To determine whether patients are more adherent to generic statins versus brand-name statins ...

    • Comparative Effectiveness of Induction Therapy for Human Immunodeficiency Virus-Associated Cryptococcal Meningitis: A Network Meta-Analysis 

      Campbell, Jeffrey I.; Kanters, Steve; Bennett, John E.; Thorlund, Kristian; Tsai, Alexander C.; Mills, Edward J.; Siedner, Mark J. (Oxford University Press, 2015)
      Background. Multiple international treatment guidelines recommend amphotericin-based combination regimens for induction therapy of cryptococcal meningitis. Yet, only 1 trial has reported a mortality benefit for combination ...

    • Comparative effectiveness of post-discharge interventions for hospitalized smokers: Study protocol for a randomized controlled trial 

      Japuntich, Sandra J; Regan, Susan; Viana, Joseph; Tymoszczuk, Justyna; Reyen, Michele; Levy, Douglas Edward; Singer, Daniel Edwin; Park, Elyse Richelle; Chang, Yuchiao; Rigotti, Nancy Ann (BioMed Central, 2012)
      Background: A hospital admission offers smokers an opportunity to quit. Smoking cessation counseling provided in the hospital is effective, but only if it continues for more than one month after discharge. Providing smoking ...

    • Comparative effectiveness of post-discharge strategies for hospitalized smokers: study protocol for the Helping HAND 2 randomized controlled trial 

      Reid, Zachary Z; Regan, Susan; Kelley, Jennifer HK; Streck, Joanna M; Ylioja, Thomas; Tindle, Hilary A; Chang, Yuchiao; Levy, Douglas E; Park, Elyse R; Singer, Daniel E; Carpenter, Kelly M; Reyen, Michele; Rigotti, Nancy A (BioMed Central, 2015)
      Background: Smoking cessation interventions for hospitalized smokers are effective in promoting smoking cessation, but only if the tobacco dependence treatment continues after the patient leaves the hospital. Sustaining ...

    • Comparative Effectiveness Research Using Observational Data: Active Comparators to Emulate Target Trials with Inactive Comparators 

      Huitfeldt, Anders; Hernan, Miguel A.; Kalager, Mette; Robins, James M. (AcademyHealth, 2016)
      Introduction: Because a comparison of noninitiators and initiators of treatment may be hopelessly confounded, guidelines for the conduct of observational research often recommend using an “active” comparator group consisting ...

    • Comparative Effectiveness Research: An Empirical Study of Trials Registered in ClinicalTrials.gov 

      Bourgeois, Florence Tanya; Murthy, Srinivas; Mandl, Kenneth David (Public Library of Science, 2012)
      Background: The $1.1 billion investment in comparative effectiveness research will reshape the evidence-base supporting decisions about treatment effectiveness, safety, and cost. Defining the current prevalence and ...

    • Comparative efficacy and acceptability of psychotherapies for acute anxiety disorders in children and adolescents: study protocol for a network meta-analysis 

      Zhang, Yuqing; Zhou, Xinyu; James, Anthony C; Qin, Bin; Whittington, Craig J; Cuijpers, Pim; Del Giovane, Cinzia; Liu, Yiyun; Cohen, David; Weisz, John R; Xie, Peng (BMJ Publishing Group, 2015)
      Introduction: Anxiety disorders are associated with significant public health burden in young individuals. Cognitive-behavioural therapy (CBT) is the most commonly used psychotherapy for anxiety disorders in children and ...

    • A Comparative Encyclopedia of DNA Elements in the Mouse Genome 

      Yue, Feng; Cheng, Yong; Breschi, Alessandra; Vierstra, Jeff; Wu, Weisheng; Ryba, Tyrone; Sandstrom, Richard; Ma, Zhihai; Davis, Carrie; Pope, Benjamin D.; Shen, Yin; Pervouchine, Dmitri D.; Djebali, Sarah; Thurman, Bob; Kaul, Rajinder; Rynes, Eric; Kirilusha, Anthony; Marinov, Georgi K.; Williams, Brian A.; Trout, Diane; Amrhein, Henry; Fisher-Aylor, Katherine; Antoshechkin, Igor; DeSalvo, Gilberto; See, Lei-Hoon; Fastuca, Meagan; Drenkow, Jorg; Zaleski, Chris; Dobin, Alex; Prieto, Pablo; Lagarde, Julien; Bussotti, Giovanni; Tanzer, Andrea; Denas, Olgert; Li, Kanwei; Bender, M. A.; Zhang, Miaohua; Byron, Rachel; Groudine, Mark T.; McCleary, David; Pham, Long; Ye, Zhen; Kuan, Samantha; Edsall, Lee; Wu, Yi-Chieh; Rasmussen, Matthew D.; Bansal, Mukul S.; Keller, Cheryl A.; Morrissey, Christapher S.; Mishra, Tejaswini; Jain, Deepti; Dogan, Nergiz; Harris, Robert S.; Cayting, Philip; Kawli, Trupti; Boyle, Alan P.; Euskirchen, Ghia; Kundaje, Anshul; Lin, Shin; Lin, Yiing; Jansen, Camden; Malladi, Venkat S.; Cline, Melissa S.; Erickson, Drew T.; Kirkup, Vanessa M; Learned, Katrina; Sloan, Cricket A.; Rosenbloom, Kate R.; de Sousa, Beatriz Lacerda; Beal, Kathryn; Pignatelli, Miguel; Flicek, Paul; Lian, Jin; Kahveci, Tamer; Lee, Dongwon; Kent, W. James; Santos, Miguel Ramalho; Herrero, Javier; Notredame, Cedric; Johnson, Audra; Vong, Shinny; Lee, Kristen; Bates, Daniel; Neri, Fidencio; Diegel, Morgan; Canfield, Theresa; Sabo, Peter J.; Wilken, Matthew S.; Reh, Thomas A.; Giste, Erika; Shafer, Anthony; Kutyavin, Tanya; Haugen, Eric; Dunn, Douglas; Reynolds, Alex P.; Neph, Shane; Humbert, Richard; Hansen, R. Scott; De Bruijn, Marella; Selleri, Licia; Rudensky, Alexander; Josefowicz, Steven; Samstein, Robert; Eichler, Evan E.; Orkin, Stuart H.; Levasseur, Dana; Papayannopoulou, Thalia; Chang, Kai-Hsin; Skoultchi, Arthur; Gosh, Srikanta; Disteche, Christine; Treuting, Piper; Wang, Yanli; Weiss, Mitchell J.; Blobel, Gerd A.; Good, Peter J.; Lowdon, Rebecca F.; Adams, Leslie B.; Zhou, Xiao-Qiao; Pazin, Michael J.; Feingold, Elise A.; Wold, Barbara; Taylor, James; Kellis, Manolis; Mortazavi, Ali; Weissman, Sherman M.; Stamatoyannopoulos, John; Snyder, Michael P.; Guigo, Roderic; Gingeras, Thomas R.; Gilbert, David M.; Hardison, Ross C.; Beer, Michael A.; Ren, Bing (2014)
      Summary As the premier model organism in biomedical research, the laboratory mouse shares the majority of protein-coding genes with humans, yet the two mammals differ in significant ways. To gain greater insights into both ...