Browsing HMS Scholarly Articles by Title

Now showing items 3252-3271 of 17922

    • Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies 

      Li, Yun R.; van Setten, Jessica; Verma, Shefali S.; Lu, Yontao; Holmes, Michael V.; Gao, Hui; Lek, Monkol; Nair, Nikhil; Chandrupatla, Hareesh; Chang, Baoli; Karczewski, Konrad J.; Wong, Chanel; Mohebnasab, Maede; Mukhtar, Eyas; Phillips, Randy; Tragante, Vinicius; Hou, Cuiping; Steel, Laura; Lee, Takesha; Garifallou, James; Guettouche, Toumy; Cao, Hongzhi; Guan, Weihua; Himes, Aubree; van Houten, Jacob; Pasquier, Andrew; Yu, Reina; Carrigan, Elena; Miller, Michael B.; Schladt, David; Akdere, Abdullah; Gonzalez, Ana; Llyod, Kelsey M.; McGinn, Daniel; Gangasani, Abhinav; Michaud, Zach; Colasacco, Abigail; Snyder, James; Thomas, Kelly; Wang, Tiancheng; Wu, Baolin; Alzahrani, Alhusain J.; Al-Ali, Amein K.; Al-Muhanna, Fahad A.; Al-Rubaish, Abdullah M.; Al-Mueilo, Samir; Monos, Dimitri S.; Murphy, Barbara; Olthoff, Kim M.; Wijmenga, Cisca; Webster, Teresa; Kamoun, Malek; Balasubramanian, Suganthi; Lanktree, Matthew B.; Oetting, William S.; Garcia-Pavia, Pablo; MacArthur, Daniel G.; de Bakker, Paul I W; Hakonarson, Hakon; Birdwell, Kelly A.; Jacobson, Pamala A.; Ritchie, Marylyn D.; Asselbergs, Folkert W.; Israni, Ajay K.; Shaked, Abraham; Keating, Brendan J. (BioMed Central, 2015)
      Background: In addition to HLA genetic incompatibility, non-HLA difference between donor and recipients of transplantation leading to allograft rejection are now becoming evident. We aimed to create a unique genome-wide ...

    • Concept, Design and Implementation of a Cardiovascular Gene-centric 50 K SNP Array for Large-scale Genomic Association Studies 

      Keating, Brendan J.; Tischfield, Sam; Murray, Sarah S.; Bhangale, Tushar; Price, Thomas S.; Glessner, Joseph T.; Galver, Luana; Barrett, Jeffrey C.; Grant, Struan F. A.; Farlow, Deborah N.; Chandrupatla, Hareesh R.; Ajmal, Saad; Papanicolaou, George J.; Guo, Yiran; Li, Mingyao; DerOhannessian, Stephanie; Bailey, Swneke D.; Montpetit, Alexandre; Edmondson, Andrew C.; Taylor, Kent; Gai, Xiaowu; Wang, Susanna S.; Fornage, Myriam; Shaikh, Tamim; Groop, Leif; Boehnke, Michael; Hall, Alistair S.; Hattersley, Andrew T.; Frackelton, Edward; Patterson, Nick; Chiang, Charleston W. K.; Kim, Cecelia E.; Fabsitz, Richard R.; Ouwehand, Willem; Munroe, Patricia; Caulfield, Mark; Drake, Thomas; Boerwinkle, Eric; Whitehead, A. Stephen; Cappola, Thomas P.; Samani, Nilesh J.; Lusis, A. Jake; Schadt, Eric; Wilson, James G.; Koenig, Wolfgang; McCarthy, Mark I.; Kathiresan, Sekar; Gabriel, Stacey B.; Hakonarson, Hakon; Anand, Sonia S.; Reilly, Muredach; Engert, James C.; Nickerson, Deborah A.; Rader, Daniel J.; FitzGerald, Garret A.; Reitsma, Pieter H.; Hansen, Mark; de Bakker, Paul I Wen; Price, Alkes; Reich, David Emil; Hirschhorn, Joel Naom (Public Library of Science, 2008)
      A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide association studies ...

    • Conceptions of decision-making capacity in psychiatry: interviews with Swedish psychiatrists 

      Sjöstrand, Manne; Karlsson, Petter; Sandman, Lars; Helgesson, Gert; Eriksson, Stefan; Juth, Niklas (BioMed Central, 2015)
      Background: Decision-making capacity is a key concept in contemporary healthcare ethics. Previous research has mainly focused on philosophical, conceptual issues or on evaluation of different tools for assessing patients’ ...

    • Concepts and Principles of Photodynamic Therapy as an Alternative Antifungal Discovery Platform 

      Dai, Tianhong; Fuchs, Beth B.; Coleman, Jeffrey James; Prates, Renato A.; Astrakas, Christos; St. Denis, Tyler G.; Ribeiro, Martha S.; Mylonakis, Eleftherios; Hamblin, Michael; Tegos, George (Frontiers Research Foundation, 2012)
      Opportunistic fungal pathogens may cause superficial or serious invasive infections, especially in immunocompromised and debilitated patients. Invasive mycoses represent an exponentially growing threat for human health due ...

    • Conceptual and Data-based Investigation of Genetic Influences and Brain Asymmetry: A Twin Study of Multiple Structural Phenotypes 

      Eyler, Lisa T.; Vuoksimaa, Eero; Panizzon, Matthew S.; Fennema-Notestine, Christine; Neale, Michael C.; Chen, Chi-Hua; Jak, Amy; Franz, Carol E.; Lyons, Michael J.; Thompson, Wesley K.; Spoon, Kelly M.; Fischl, Bruce; Dale, Anders M.; Kremen, William S. (Massachusetts Institute of Technology Press (MIT Press), 2014)
      Right-left regional cerebral differences are a feature of the human brain linked to functional abilities, aging, and neurodevelopmental and mental disorders. The role of genetic factors in structural asymmetry has been ...

    • A Conceptual Framework to Measure Systems’ Performance during Emergency Preparedness Exercises 

      Savoia, Elena; Agboola, Foluso; Biddinger, Paul D. (MDPI, 2014)
      Large-scale public health emergencies require a sophisticated, coordinated response involving multiple entities to protect health and minimize suffering. However, the rarity of such emergencies presents a barrier to gathering ...

    • Conceptualizing Integration: A Framework for Analysis Applied to Neglected Tropical Disease Control Partnerships 

      Grépin, Karen A.; Reich, Michael Robin (Public Library of Science, 2008)

    • Concerning RNA-guided gene drives for the alteration of wild populations 

      Esvelt, Kevin M; Smidler, Andrea L; Catteruccia, Flaminia; Church, George M (eLife Sciences Publications, Ltd, 2014)
      Gene drives may be capable of addressing ecological problems by altering entire populations of wild organisms, but their use has remained largely theoretical due to technical constraints. Here we consider the potential for ...

    • Concerted nucleophilic aromatic substitution with 19F− and 18F− 

      Neumann, Constanze N.; Hooker, Jacob M.; Ritter, Tobias (2016)
      Nucleophilic aromatic substitution (SNAr) is widely used by organic chemists to functionalize aromatic molecules, and it is the most commonly used method to generate arenes that contain a 18F for use in PET imaging.1 A ...

    • Concise Review: Comparison of Culture Membranes Used for Tissue Engineered Conjunctival Epithelial Equivalents 

      Eidet, Jon Roger; Dartt, Darlene A.; Utheim, Tor Paaske (MDPI, 2015)
      The conjunctival epithelium plays an important role in ensuring the optical clarity of the cornea by providing lubrication to maintain a smooth, refractive surface, by producing mucins critical for tear film stability and ...

    • Concomitant Enterotoxigenic Escherichia coli Infection Induces Increased Immune Responses to Vibrio cholerae O1 Antigens in Patients with Cholera in Bangladesh 

      Chowdhury, Fahima; Begum, Yasmin A.; Alam, Mohammad Murshid; Khan, Ashraful I.; Ahmed, Tanvir; Bhuiyan, M. Saruar; Harris, Jason B.; LaRocque, Regina C.; Faruque, Abu G.; Endtz, Hubert; Ryan, Edward T.; Cravioto, Alejandro; Svennerholm, Ann-Mari; Calderwood, Stephen B.; Qadri, Firdausi (American Society for Microbiology, 2010)
      Vibrio cholerae O1 and enterotoxigenic Escherichia coli (ETEC) are major bacterial pathogens that cause dehydrating disease requiring hospitalization of children and adults. The cholera toxin (CT) produced by V. cholerae ...

    • Concomitant Socioeconomic, Behavioral, and Biological Factors Associated with the Disproportionate HIV Infection Burden among Black Men Who Have Sex with Men in 6 U.S. Cities 

      Mayer, Kenneth H.; Wang, Lei; Koblin, Beryl; Mannheimer, Sharon; Magnus, Manya; del Rio, Carlos; Buchbinder, Susan; Wilton, Leo; Cummings, Vanessa; Watson, Christopher C.; Piwowar-Manning, Estelle; Gaydos, Charlotte; Eshleman, Susan H.; Clarke, William; Liu, Ting-Yuan; Mao, Cherry; Griffith, Samuel; Wheeler, Darrell (Public Library of Science, 2014)
      Background: American Black men who have sex with men (MSM) are disproportionately affected by HIV, but the factors associated with this concentrated epidemic are not fully understood. Methods: Black MSM were enrolled in 6 ...

    • Concomitant Use of Single Antiplatelet Therapy With Edoxaban or Warfarin in Patients With Atrial Fibrillation: Analysis From the ENGAGE AF‐TIMI48 Trial 

      Xu, Haiyan; Ruff, Christian T.; Giugliano, Robert P.; Murphy, Sabina A.; Nordio, Francesco; Patel, Indravadan; Shi, Minggao; Mercuri, Michele; Antman, Elliott M.; Braunwald, Eugene (John Wiley and Sons Inc., 2016)
      Background: We studied the concomitant use of single antiplatelet therapy (SAPT) on the efficacy and safety of the anti‐Xa agent edoxaban in patients with atrial fibrillation (AF). Methods and Results: ENGAGE AF‐TIMI 48 ...

    • Concordance and predictive value of two adverse drug event data sets 

      Cami, Aurel; Reis, Ben Y (BioMed Central, 2014)
      Background: Accurate prediction of adverse drug events (ADEs) is an important means of controlling and reducing drug-related morbidity and mortality. Since no single “gold standard” ADE data set exists, a range of different ...

    • Concordance Between BeamF3 and MRI-neuronavigated Target Sites for Repetitive Transcranial Magnetic Stimulation of the Left Dorsolateral Prefrontal Cortex 

      Mir-Moghtadaei, Arsalan; Caballero, Ruth; Fried, Peter; Fox, Michael D.; Lee, Katherine; Giacobbe, Peter; Daskalakis, Zafiris J.; Blumberger, Daniel M.; Downar, Jonathan (2016)
      Background: The dorsolateral prefrontal cortex (DLPFC) is a common target for repetitive transcranial magnetic stimulation (rTMS) in major depression, but the conventional “5 cm rule” misses DLPFC in > 1/3 cases. Another ...

    • Concordance between DSM-IV and DSM-5 criteria for delirium diagnosis in a pooled database of 768 prospectively evaluated patients using the delirium rating scale-revised-98 

      Meagher, David J; Morandi, Alessandro; Inouye, Sharon K; Ely, Wes; Adamis, Dimitrios; Maclullich, Alasdair J; Rudolph, James L; Neufeld, Karin; Leonard, Maeve; Bellelli, Giuseppe; Davis, Daniel; Teodorczuk, Andrew; Kreisel, Stefan; Thomas, Christine; Hasemann, Wolfgang; Timmons, Suzanne; O’Regan, Niamh; Grover, Sandeep; Jabbar, Faiza; Cullen, Walter; Dunne, Colum; Kamholz, Barbara; Van Munster, Barbara C; De Rooij, Sophia E; De Jonghe, Jos; Trzepacz, Paula T (BioMed Central, 2014)
      Background: The Diagnostic and Statistical Manual fifth edition (DSM-5) provides new criteria for delirium diagnosis. We examined delirium diagnosis using these new criteria compared with the Diagnostic and Statistical ...

    • Concordance of gene expression in human protein complexes reveals tissue specificity and pathology 

      Börnigen, Daniela; Pers, Tune H.; Thorrez, Lieven; Huttenhower, Curtis; Moreau, Yves; Brunak, Søren (Oxford University Press, 2013)
      Disease-causing variants in human genes usually lead to phenotypes specific to only a few tissues. Here, we present a method for predicting tissue specificity based on quantitative deregulation of protein complexes. The ...

    • Concurrent Chemoradiation for Vaginal Cancer 

      Miyamoto, David T.; Viswanathan, Akila N. (Public Library of Science, 2013)
      Background: It is not known whether the addition of chemotherapy to radiation therapy improves outcomes in primary vaginal cancer. Here, we review clinical outcomes in patients with primary vaginal cancer treated with ...

    • Concurrent muscle and bone deterioration in a murine model of cancer cachexia 

      Choi, EunHi; Carruthers, Kadir; Zhang, Li; Thomas, Nathan; Battaglino, Ricardo A; Morse, Leslie R; Widrick, Jeffrey J (Blackwell Publishing Ltd, 2013)
      Cachexia is defined as an excessive, involuntary loss of fat and lean tissue. We tested the validity of the Lewis lung carcinoma (LLC) as a model of cancer cachexia and examined its effect on the two major lean tissue ...

    • Concussion management in US college football: progress and pitfalls 

      Baugh, Christine M; Kroshus, Emily (2015)
      Reducing the frequency and severity of concussions from sport is an important issue in public health currently addressed by a multifaceted approach. Given the large number of participants and the comparatively high risk ...