Browsing HMS Scholarly Articles by Title

Now showing items 3369-3388 of 17922

    • Context-Specific Ontology Integration: A Bayesian Approach 

      Marwah, Kshitij; Katzin, Dustin; Zollanvari, Amin; Noy, Natalya F.; Ramoni, Marco; Alterovitz, Gil (American Medical Informatics Association, 2012)
      We introduce a principled computational framework and methodology for automated discovery of context-specific functional links between ontologies. Our model leverages over disparate free-text literature resources to score ...

    • Contextual role for angiopoietins and TGFbeta1 in blood vessel stabilization 

      Ramsauer, Markus; D'Amore, Patricia Ann (The Company of Biologists, 2007)
      We used a 3D in-vitro model of angiogenesis to investigate the effects of different growth factors on vessel formation and stabilization in vitro. Vascular endothelial growth factor (VEGF) was the only factor that induced ...

    • Contextualized analysis of a needs assessment using the Theoretical Domains Framework: a case example in endocrinology 

      Lazure, Patrice; Bartel, Robert C; Biller, Beverly MK; Molitch, Mark E; Rosenthal, Stephen M; Ross, Judith L; Bernsten, Brock D; Hayes, Sean M (BioMed Central, 2014)
      Background: The Theoretical Domains Framework (TDF) is a set of 14 domains of behavior change that provide a framework for the critical issues and factors influencing optimal knowledge translation. Considering that a ...

    • Contextualizing mental health: gendered experiences in a Mumbai slum 

      Parkar, Shubhangi R.; Fernandes, Johnson; Weiss, Mitchell Gralnick (Informa UK Limited, 2003)
      Urban mental health programmes in developing countries remain in their infancy. To serve low-income communities, research needs to consider the impact of common life experience in slums, including poverty, bad living ...

    • Continuous directed evolution of DNA-binding proteins to improve TALEN specificity 

      Hubbard, Basil P.; Badran, Ahmed H.; Zuris, John A.; Guilinger, John P.; Davis, Kevin M.; Chen, Liwei; Tsai, Shengdar Q.; Sander, Jeffry D.; Joung, J. Keith; Liu, David R. (2015)
      Nucleases containing programmable DNA-binding domains can alter the genomes of model organisms and have the potential to become human therapeutics. Here we present DNA-binding phage-assisted continuous evolution (DB-PACE) ...

    • Continuous Flow Microfluidic Bioparticle Concentrator 

      Martel, Joseph M.; Smith, Kyle C.; Dlamini, Mcolisi; Pletcher, Kendall; Yang, Jennifer; Karabacak, Murat; Haber, Daniel A.; Kapur, Ravi; Toner, Mehmet (Nature Publishing Group, 2015)
      Innovative microfluidic technology has enabled massively parallelized and extremely efficient biological and clinical assays. Many biological applications developed and executed with traditional bulk processing techniques ...

    • Continuous Flow-Driven Inversion for Arterial Spin Labeling Using Pulsed Radio Frequency and Gradient Fields 

      Dai, Weiying; Garcia, Dairon; de Bazelaire, Cedric; Alsop, David (Wiley, 2008-12)
      Continuous labeling by flow driven adiabatic inversion is advantageous for arterial spin labeling (ASL) perfusion studies, but details of the implementation, including inefficiency, magnetization transfer, and limited ...

    • Continuous Positive Airway Pressure 

      Babar, Sardar I.; Quan, Stuart (American Medical Association (AMA), 2003-03-10)

    • Continuous Spikes and Waves during Sleep: Electroclinical Presentation and Suggestions for Management 

      Sánchez Fernández, Iván; Chapman, Kevin E.; Peters, Jurriaan M.; Harini, Chellamani; Rotenberg, Alexander; Loddenkemper, Tobias (Hindawi Publishing Corporation, 2013)
      Continuous spikes and waves during sleep (CSWS) is an epileptic encephalopathy characterized in most patients by (1) difficult to control seizures, (2) interictal epileptiform activity that becomes prominent during sleep ...

    • The Continuous Wagon Wheel Illusion and the ‘When’ Pathway of the Right Parietal Lobe: A Repetitive Transcranial Magnetic Stimulation Study 

      VanRullen, Rufin; Pascual-Leone, Alvaro; Battelli, Lorella (Public Library of Science, 2008)
      A continuous periodic motion stimulus can sometimes be perceived moving in the wrong direction. These illusory reversals have been taken as evidence that part of the motion perception system samples its inputs as a series ...

    • Contraction and AICAR Stimulate IL-6 Vesicle Depletion From Skeletal Muscle Fibers In Vivo 

      Lauritzen, Hans P.M.M.; Brandauer, Josef; Schjerling, Peter; Koh, Ho-Jin; Treebak, Jonas T.; Hirshman, Michael F.; Galbo, Henrik; Goodyear, Laurie J. (American Diabetes Association, 2013)
      Recent studies suggest that interleukin 6 (IL-6) is released from contracting skeletal muscles; however, the cellular origin, secretion kinetics, and signaling mechanisms regulating IL-6 secretion are unknown. To address ...

    • Contraction stimulates muscle glucose uptake independent of atypical PKC 

      Yu, Haiyan; Fujii, Nobuharu L; Toyoda, Taro; An, Ding; Farese, Robert V; Leitges, Michael; Hirshman, Michael F; Mul, Joram D; Goodyear, Laurie J (John Wiley & Sons, Ltd, 2015)
      Exercise increases skeletal muscle glucose uptake, but the underlying mechanisms are only partially understood. The atypical protein kinase C (PKC) isoforms λ and ζ (PKC-λ/ζ) have been shown to be necessary for insulin-, ...

    • Contralateral Clinically Unaffected Eyes of Patients With Unilateral Infectious Keratitis Demonstrate a Sympathetic Immune Response 

      Cruzat, Andrea; Schrems, Wolfgang A.; Schrems-Hoesl, Laura M.; Cavalcanti, Bernardo M.; Baniasadi, Neda; Witkin, Deborah; Pavan-Langston, Deborah; Dana, Reza; Hamrah, Pedram (Association for Research in Vision and Ophthalmology (ARVO), 2015)
      Purpose To analyze the contralateral unaffected eyes of patients with microbial keratitis (MK) for any immune cell or nerve changes by laser in vivo confocal microscopy (IVCM). Methods A prospective study was ...

    • Contrast inhomogeneity in CT angiography of the abdominal aortic aneurysm 

      George, Elizabeth; Giannopoulos, Andreas A.; Aghayev, Ayaz; Rohatgi, Saurabh; Imanzadeh, Amir; Antoniadis, Antonios P.; Kumamaru, Kanako; Chatzizisis, Yiannis; Dunne, Ruth Mary; Steigner, Michael L.; Hanley, Michael; Gravereaux, Edwin Charles; Rybicki, Frank; Mitsouras, Dimitrios (Elsevier BV, 2016)
      Background If undetected, infrarenal Abdominal Aortic Aneurysm (AAA) growth can lead to rupture, a high-mortality complication. Some AAA patients exhibit inhomogeneous luminal contrast attenuation at first-pass CT ...

    • Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance components analysis 

      Loh, Po-Ru; Bhatia, Gaurav; Gusev, Alexander; Finucane, Hilary K; Bulik-Sullivan, Brendan K; Pollack, Samuela J; de Candia, Teresa R; Lee, Sang Hong; Wray, Naomi R; Kendler, Kenneth S; O’Donovan, Michael C; Neale, Benjamin M; Patterson, Nick; Price, Alkes L (2015)
      Heritability analyses of GWAS cohorts have yielded important insights into complex disease architecture, and increasing sample sizes hold the promise of further discoveries. Here, we analyze the genetic architecture of ...

    • Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 Diabetes 

      Thornley, Thomas B.; Agarwal, Krishna A.; Kyriazis, Periklis; Ma, Lingzhi; Chipashvili, Vaja; Aker, Jonathan E.; Korniotis, Sarantis; Csizmadia, Eva; Strom, Terry B.; Koulmanda, Maria (Public Library of Science, 2016)
      The innate immune system critically shapes diabetogenic adaptive immunity during type 1 diabetes (T1D) pathogenesis. While the role of tissue-infiltrating monocyte-derived macrophages in T1D is well established, the role ...

    • Contrasting within- and between-host immune selection shapes Neisseria Opa repertoires 

      Watkins, Eleanor R.; Grad, Yonatan H.; Gupta, Sunetra; Buckee, Caroline O. (Nature Publishing Group, 2014)
      Pathogen evolution is influenced strongly by the host immune response. Previous studies of the effects of herd immunity on the population structure of directly transmitted, short-lived pathogens have primarily focused on ...

    • Contribution of a Low-Barrier Hydrogen Bond to Catalysis Is Not Significant in Ketosteroid Isomerase 

      Jang, Do Soo; Choi, Gildon; Cha, Hyung Jin; Shin, Sejeong; Hong, Bee Hak; Lee, Hyeong Ju; Lee, Hee Cheon; Choi, Kwan Yong (Korean Society for Molecular and Cellular Biology, 2015)
      Low-barrier hydrogen bonds (LBHBs) have been proposed to have important influences on the enormous reaction rate increases achieved by many enzymes. Δ5-3-ketosteroid isomerase (KSI) catalyzes the allylic isomerization of ...

    • The Contribution of Cervicovaginal Infections to the Immunomodulatory Effects of Hormonal Contraception 

      Fichorova, Raina N.; Chen, Pai-Lien; Morrison, Charles S.; Doncel, Gustavo F.; Mendonca, Kevin; Kwok, Cynthia; Chipato, Tsungai; Salata, Robert; Mauck, Christine (American Society of Microbiology, 2015)
      ABSTRACT Particular types of hormonal contraceptives (HCs) and genital tract infections have been independently associated with risk of HIV-1 acquisition. We examined whether immunity in women using injectable depot ...

    • The Contribution of Cortical Lesions to a Composite MRI Scale of Disease Severity in Multiple Sclerosis 

      Yousuf, Fawad; Kim, Gloria; Tauhid, Shahamat; Glanz, Bonnie I.; Chu, Renxin; Tummala, Subhash; Healy, Brian C.; Bakshi, Rohit (Frontiers Media S.A., 2016)
      Objective: To test a new version of the Magnetic Resonance Disease Severity Scale (v.3 = MRDSS3) for multiple sclerosis (MS), incorporating cortical gray matter lesions (CLs) from 3T magnetic resonance imaging (MRI). ...