Browsing HMS Scholarly Articles by Title

Now showing items 3570-3589 of 17922

    • Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner 

      Xie, Liang; Duncan, Michael B.; Pahler, Jessica; Sugimoto, Hikaru; Martino, Margot; Lively, Julie; Mundel, Thomas; Soubasakos, Mary; Rubin, Kristofer; Takeda, Takaaki; Inoue, Masahiro; Lawler, Jack; Hynes, Richard O.; Hanahan, Douglas; Kalluri, Raghu (National Academy of Sciences, 2011)
      Whereas the roles of proangiogenic factors in carcinogenesis are well established, those of endogenous angiogenesis inhibitors (EAIs) remain to be fully elaborated. We investigated the roles of three EAIs during de novo ...

    • Countervailing effects of income, air pollution, smoking, and obesity on aging and life expectancy: population-based study of U.S. Counties 

      Allen, Ryan T.; Hales, Nicholas M.; Baccarelli, Andrea; Jerrett, Michael; Ezzati, Majid; Dockery, Douglas W.; Pope, C. Arden (BioMed Central, 2016)
      Background: Income, air pollution, obesity, and smoking are primary factors associated with human health and longevity in population-based studies. These four factors may have countervailing impacts on longevity. This ...

    • Countrywise results of total hip replacement: An analysis of 438,733 hips based on the Nordic Arthroplasty Register Association database 

      Mäkelä, Keijo T; Matilainen, Markus; Pulkkinen, Pekka; Fenstad, Anne M; Havelin, Leif I; Engesaeter, Lars; Furnes, Ove; Overgaard, Søren; Pedersen, Alma B; Kärrholm, Johan; Malchau, Henrik; Garellick, Göran; Ranstam, Jonas; Eskelinen, Antti (Informa Healthcare, 2014)
      Background and purpose An earlier Nordic Arthroplasty Register Association (NARA) report on 280,201 total hip replacements (THRs) based on data from 1995–2006, from Sweden, Norway, and Denmark, was published in 2009. The ...

    • County Poverty Concentration and Disparities in Unintentional Injury Deaths: A Fourteen-Year Analysis of 1.6 Million U.S. Fatalities 

      Karb, Rebecca A.; Subramanian, S.V. Venkata; Fleegler, Eric William (Public Library of Science (PLoS), 2016)
      Unintentional injury is the fourth leading cause of death in the United States, and mortality due to injury has risen over the past decade. The social determinants behind these rising trends have not been well documented. ...

    • Coupling dTTP Hydrolysis with DNA Unwinding by the DNA Helicase of Bacteriophage T7 

      Satapathy, Ajit K.; Kulczyk, Arkadiusz W.; Ghosh, Sharmistha; Oijen, Antoine van; Richardson, Charles C. (American Society for Biochemistry and Molecular Biology, 2011)
      The DNA helicase encoded by gene 4 of bacteriophage T7 assembles on single-stranded DNA as a hexamer of six identical subunits with the DNA passing through the center of the toroid. The helicase couples the hydrolysis of ...

    • The Course of Persistent Airflow Limitation in Subjects With and Without Asthma 

      Guerra, Stefano; Sherrill, Duane L.; Kurzius-Spencer, Margaret; Venker, Claire; Halonen, Marilyn; Quan, Stuart; Martinez, Fernando D. (Elsevier BV, 2008-10)
      Rationale Most patients who develop persistent airflow limitation do so either as a manifestation of chronic obstructive pulmonary disease that is largely related to smoking or as a consequence of persistent asthma. We ...

    • The Course of Response to Focal/grid Photocoagulation for Diabetic Macular Edema 

      Aiello, Lloyd Paul (Ovid, 2009)
      Purpose: To determine whether eyes with center involved diabetic macular edema (DME), treated with focal/grid photocoagulation, in which there is a reduction in central subfield thickness (CST) measured with optical coherence ...

    • Covalent inhibition of pro-apoptotic BAX 

      Mchenry, Matthew; Shi, Peiwen; Camara, Christina M.; Cohen, Daniel T.; Rettenmaier, T. Justin; Adhikary, Utsarga; Gygi, Micah A.; Yang, Ka; Gygi, Steven P.; Wales, Thomas E.; Engen, John R.; Wells, James A.; Walensky, Loren D. (Springer Science and Business Media LLC, 2024-01-17)

    • Coverage and timing of antenatal care among poor women in 6 Mesoamerican countries 

      Dansereau, Emily; McNellan, Claire R.; Gagnier, Marielle C.; Desai, Sima S.; Haakenstad, Annie; Johanns, Casey K.; Palmisano, Erin B.; Ríos-Zertuche, Diego; Schaefer, Alexandra; Zúñiga-Brenes, Paola; Hernandez, Bernardo; Iriarte, Emma; Mokdad, Ali H. (BioMed Central, 2016)
      Background: Poor women in the developing world have a heightened need for antenatal care (ANC) but are often the least likely to attend it. This study examines factors associated with the number and timing of ANC visits ...

    • Coverage by the News Media of the Benefits and Risks of Medications 

      Moynihan, Ray; Bero, Lisa; Ross-Degnan, Dennis; Henry, David; Lee, Kirby; Watkins, Judy; Mah, Connie; Soumerai, Stephen Bertram (New England Journal of Medicine (NEJM/MMS), 2000)
      Background The news media are an important source of information about new medical treatments, but there is concern that some coverage may be in- accurate and overly enthusiastic. Methods We studied coverage by U.S. news ...

    • Coverage recommendations for methylation analysis by whole genome bisulfite sequencing 

      Ziller, Michael J.; Hansen, Kasper D.; Meissner, Alexander; Aryee, Martin J. (2014)
      Whole genome bisulfite sequencing (WGBS) allows genome-wide DNA methylation profiling but the associated high sequencing costs continue to limit its widespread application. We utilized several high coverage reference data ...

    • Covert Waking Brain Activity Reveals Instantaneous Sleep Depth 

      McKinney, Scott M.; Dang-Vu, Thien Thanh; Buxton, Orfeu Marcello; Solet, Jo Marie; Ellenbogen, Jeffrey Michael (Public Library of Science, 2011)
      The neural correlates of the wake-sleep continuum remain incompletely understood, limiting the development of adaptive drug delivery systems for promoting sleep maintenance. The most useful measure for resolving early ...

    • COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets 

      Shalek, Alex K. (Springer Science and Business Media LLC, 2021-04-29)
      COVID-19, caused by SARS-CoV-2, can result in acute respiratory distress syndrome and multiple-organ failure, but little is known about its pathophysiology. Here, we generated single-cell atlases of 23 lung, 16 kidney, 16 ...

    • Cox Model Setup: Garshick et al. Respond 

      Garshick, Eric; Laden, Francine; Hart, Jaime Elizabeth; Davis, Mary Elizabeth; Eisen, Ellen A.; Smith, Thomas J. (National Institute of Environmental Health Sciences, 2012)

    • Cox-2 Inhibition Enhances the Activity of Sunitinib in Human Renal Cell Carcinoma Xenografts 

      Wang, Xiaoen; Zhang, L; O'Neill, A; Bahamon, B; Alsop, David C.; Mier, James W.; Goldberg, S. Nahum; Signoretti, Sabina; Atkins, M B; Wood, C G; Bhatt, Rupal Satish (Nature Publishing Group, 2013)
      Background: Sunitinib (Su), a tyrosine kinase inhibitor of VEGFR, is effective at producing tumour response in clear cell renal cell carcinoma (cRCC), but resistance to therapy is inevitable. As COX-2 is a known mediator ...

    • CPAP versus Oxygen in Obstructive Sleep Apnea 

      Gottlieb, Daniel; Punjabi, Naresh M.; Mehra, Reena; Patel, Sanjay R.; Quan, Stuart; Babineau, Denise C.; Tracy, Russell P.; Rueschman, Michael; Blumenthal, Roger S.; Lewis, Eldrin F.; Bhatt, Deepak; Redline, Susan (Massachusetts Medical Society, 2014-06-12)
      Background Obstructive sleep apnea is associated with hypertension, inflammation, and increased cardiovascular risk. Continuous positive airway pressure (CPAP) reduces blood pressure, but adherence is often suboptimal, ...

    • CPSF6 LICENSES HIV-1 INTEGRATION INTO POL II-PAUSED GENES REGULATED by P-TEFb and U2 snRNP 

      Singh, Parmit; Annamalai, Arun; Kvaratskhelia, Mamuka; Engelman, Alan (2023-05)
      Pre-mRNA splicing regulates promoter-proximal Pol II pausing and alternative polyadenylation (APA). Splicing inhibitors increase pausing and use of proximal polyadenylation sites (PAS) for comparatively long (>4 introns) ...

    • CR Cistrome: a ChIP-Seq database for chromatin regulators and histone modification linkages in human and mouse 

      Wang, Qixuan; Huang, Jinyan; Sun, Hanfei; Liu, Jing; Wang, Juan; Wang, Qian; Qin, Qian; Mei, Shenglin; Zhao, Chengchen; Yang, Xiaoqin; Liu, X. Shirley; Zhang, Yong (Oxford University Press, 2013)
      Diversified histone modifications (HMs) are essential epigenetic features. They play important roles in fundamental biological processes including transcription, DNA repair and DNA replication. Chromatin regulators (CRs), ...

    • CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer's disease 

      Byun, J; Son, S M; Cha, M-Y; Shong, M; Hwang, Y J; Kim, Y; Ryu, H; Moon, M; Kim, K-S; Mook-Jung, I (Nature Publishing Group, 2015)
      Mitochondrial dysfunction, often characterized by massive fission and other morphological abnormalities, is a well-known risk factor for Alzheimer's disease (AD). One causative mechanism underlying AD-associated mitochondrial ...

    • Craft and Science in the Treatment of Traumatized People 

      Herman, Judith Lewis (Informa UK Limited, 2008)