Browsing HMS Scholarly Articles by Title

Now showing items 3582-3601 of 17922

    • COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets 

      Shalek, Alex K. (Springer Science and Business Media LLC, 2021-04-29)
      COVID-19, caused by SARS-CoV-2, can result in acute respiratory distress syndrome and multiple-organ failure, but little is known about its pathophysiology. Here, we generated single-cell atlases of 23 lung, 16 kidney, 16 ...

    • Cox Model Setup: Garshick et al. Respond 

      Garshick, Eric; Laden, Francine; Hart, Jaime Elizabeth; Davis, Mary Elizabeth; Eisen, Ellen A.; Smith, Thomas J. (National Institute of Environmental Health Sciences, 2012)

    • Cox-2 Inhibition Enhances the Activity of Sunitinib in Human Renal Cell Carcinoma Xenografts 

      Wang, Xiaoen; Zhang, L; O'Neill, A; Bahamon, B; Alsop, David C.; Mier, James W.; Goldberg, S. Nahum; Signoretti, Sabina; Atkins, M B; Wood, C G; Bhatt, Rupal Satish (Nature Publishing Group, 2013)
      Background: Sunitinib (Su), a tyrosine kinase inhibitor of VEGFR, is effective at producing tumour response in clear cell renal cell carcinoma (cRCC), but resistance to therapy is inevitable. As COX-2 is a known mediator ...

    • CPAP versus Oxygen in Obstructive Sleep Apnea 

      Gottlieb, Daniel; Punjabi, Naresh M.; Mehra, Reena; Patel, Sanjay R.; Quan, Stuart; Babineau, Denise C.; Tracy, Russell P.; Rueschman, Michael; Blumenthal, Roger S.; Lewis, Eldrin F.; Bhatt, Deepak; Redline, Susan (Massachusetts Medical Society, 2014-06-12)
      Background Obstructive sleep apnea is associated with hypertension, inflammation, and increased cardiovascular risk. Continuous positive airway pressure (CPAP) reduces blood pressure, but adherence is often suboptimal, ...

    • CPSF6 LICENSES HIV-1 INTEGRATION INTO POL II-PAUSED GENES REGULATED by P-TEFb and U2 snRNP 

      Singh, Parmit; Annamalai, Arun; Kvaratskhelia, Mamuka; Engelman, Alan (2023-05)
      Pre-mRNA splicing regulates promoter-proximal Pol II pausing and alternative polyadenylation (APA). Splicing inhibitors increase pausing and use of proximal polyadenylation sites (PAS) for comparatively long (>4 introns) ...

    • CR Cistrome: a ChIP-Seq database for chromatin regulators and histone modification linkages in human and mouse 

      Wang, Qixuan; Huang, Jinyan; Sun, Hanfei; Liu, Jing; Wang, Juan; Wang, Qian; Qin, Qian; Mei, Shenglin; Zhao, Chengchen; Yang, Xiaoqin; Liu, X. Shirley; Zhang, Yong (Oxford University Press, 2013)
      Diversified histone modifications (HMs) are essential epigenetic features. They play important roles in fundamental biological processes including transcription, DNA repair and DNA replication. Chromatin regulators (CRs), ...

    • CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer's disease 

      Byun, J; Son, S M; Cha, M-Y; Shong, M; Hwang, Y J; Kim, Y; Ryu, H; Moon, M; Kim, K-S; Mook-Jung, I (Nature Publishing Group, 2015)
      Mitochondrial dysfunction, often characterized by massive fission and other morphological abnormalities, is a well-known risk factor for Alzheimer's disease (AD). One causative mechanism underlying AD-associated mitochondrial ...

    • Craft and Science in the Treatment of Traumatized People 

      Herman, Judith Lewis (Informa UK Limited, 2008)

    • Craniectomy for Malignant Cerebral Infarction: Prevalence and Outcomes in US Hospitals 

      Walcott, Brian; Kuklina, Elena V.; Nahed, Brian Vala; George, Mary G.; Kahle, Kristopher; Simard, J. Marc; Asaad, Wael F.; Coumans, Jean-Valery C E (Public Library of Science (PLoS), 2011)
      Object: Randomized trials have demonstrated the efficacy of craniectomy for the treatment of malignant cerebral edema following ischemic stroke. We sought to determine the prevalence and outcomes related to this by using ...

    • Cranio-Spinal Migration of a Metallic Clip Placed During Arteriovenous Malformation Resection - A Case Report, Review of the Literature, and Management Strategies 

      Chen, Clark Chin-Chung; Zinn, Pascal Olivier; Kasper, Ekkehard Matthias; Ogilvy, Christopher S. (BioMed Central, 2010)
      Background: Microclip placement during AVM resection is generally accepted to be a safe practice in neurosurgery. Here, we describe an unusual complication involving cranio-spinal clip migration discovered five years after ...

    • Craniofacial features as assessed by lateral cephalometric measurements in children with Down syndrome 

      Allareddy, Veerasathpurush; Ching, Nicholas; Macklin, Eric A.; Voelz, Lauren; Weintraub, Gil; Davidson, Emily; Prock, Lisa Albers; Rosen, Dennis; Brunn, Richard; Skotko, Brian G. (Springer Berlin Heidelberg, 2016)
      Objective: The objective of the present study is to examine the craniofacial development of patients with Down syndrome (DS) and compare them with a neurotypical population. Methods: This study is a cross-sectional analysis ...

    • Craniofacial Measurements of Donors and Recipients Correlate with Aesthetic Outcome in Virtual Face Transplantation 

      S. Wallins, Joseph; Chandawarkar, Akash A.; Dobry, Allison; Diaz-Siso, J. Rodrigo; Bueno, Ericka M.; Caterson, Edward J.; Jania, Camille; Hevelone, Nathanael D.; Lipsitz, Stuart R.; Mukundan, Srinivasan; Pomahac, Bohdan (Wolters Kluwer Health, 2015)
      Background: Face transplantation is an increasingly feasible option for patients with severe disfigurement. Donors and recipients are currently matched based on immune compatibility, skin characteristics, age, and gender. ...

    • Cream Formulation Impact on Topical Administration of Engineered Colloidal Nanoparticles 

      Santini, Benedetta; Zanoni, Ivan; Marzi, Roberta; Cigni, Clara; Bedoni, Marzia; Gramatica, Furio; Palugan, Luca; Corsi, Fabio; Granucci, Francesca; Colombo, Miriam (Public Library of Science, 2015)
      In order to minimize the impact of systemic toxicity of drugs in the treatment of local acute and chronic inflammatory reactions, the achievement of reliable and efficient delivery of therapeutics in/through the skin is ...

    • Creating a Pilot Educational Psychiatry Website: Opportunities, Barriers, and Next Steps 

      Torous, John; O'Connor, Ryan; Franzen, Jamie; Snow, Caitlin; Boland, Robert; Kitts, Robert (JMIR Publications Inc., 2015)
      Background: While medical students and residents may be utilizing websites as online learning resources, medical trainees and educators now have the opportunity to create such educational websites and digital tools on their ...

    • Creating and Analyzing Pathway and Protein Interaction Compendia for Modelling Signal Transduction Networks 

      Kirouac, Daniel C; Saez-Rodriguez, Julio; Swantek, Jennifer; Burke, John M; Lauffenburger, Douglas A; Sorger, Peter Karl (BioMed Central, 2012)
      Background: Understanding the information-processing capabilities of signal transduction networks, how those networks are disrupted in disease, and rationally designing therapies to manipulate diseased states require ...

    • Creating boundaries to empower digital health technology 

      Hsin, Honor; Torous, John (Royal College of Psychiatrists, 2018-07)
      The potential of digital health tools such as smartphones and sensors to increase access to and enhance delivery of healthcare is well known. However, a lack of regulation and delineation between those technologies seeking ...

    • Creating Critical Consumers of Health and Science News: Teaching Science to the Non-Scientist Using Newsworthy Topics in the Life Sciences† 

      Coderre, Raymond W.; Uekermann, Kristen A.; Choi, Youngeun; Anderson, William J. (American Society of Microbiology, 2016)
      Scientists constantly make groundbreaking discoveries, some of which receive attention from the press. We designed a course intended for a lay audience that provides the scientific background to appreciate these reports ...

    • Creation and implementation of SAMPRO™: A school-based asthma management program 

      Lemanske, Robert F.; Kakumanu, Sujani; Shanovich, Kathleen; Antos, Nicholas; Cloutier, Michelle M.; Mazyck, Donna; Phipatanakul, Wanda; Schantz, Shirley; Szefler, Stanley; Vandlik, Renee; Williams, Paul (2016)
      Clinicians who care for children with asthma have an obligation to coordinate asthma care with the schools. Aside from routine clinical care of asthmatic children, providers must educate the family and child about the need ...

    • Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research 

      Wray, Selina; Self, Matthew; Lewis, Patrick A.; Taanman, Jan-Willem; Ryan, Natalie S.; Mahoney, Colin J.; Liang, Yuying; Devine, Michael J.; Sheerin, Una-Marie; Houlden, Henry; Morris, Huw R.; Healy, Daniel; Marti-Masso, Jose-Felix; Preza, Elisavet; Barker, Suzanne; Sutherland, Margaret; Corriveau, Roderick A.; D'Andrea, Michael; Schapira, Anthony H. V.; Uitti, Ryan J.; Guttman, Mark; Opala, Grzegorz; Jasinska-Myga, Barbara; Puschmann, Andreas; Nilsson, Christer; Espay, Alberto J.; Slawek, Jaroslaw; Gutmann, Ludwig; Boeve, Bradley F.; Boylan, Kevin; Stoessl, A. Jon; Ross, Owen A.; Maragakis, Nicholas J.; Van Gerpen, Jay; Gerstenhaber, Melissa; Gwinn, Katrina; Dawson, Ted M.; Marder, Karen S.; Clark, Lorraine N.; Przedborski, Serge E.; Finkbeiner, Steven; Rothstein, Jeffrey D.; Wszolek, Zbigniew K.; Rossor, Martin N.; Hardy, John; Isacson, Ole Stefan (Public Library of Science, 2012)
      Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation ...

    • The crisis of patient-physician trust and bioethics: lessons and inspirations from China 

      Nie, Jing-Bao; Li, Lun; Gillett, Grant; Tucker, Joseph D.; Kleinman, Arthur Michael (Wiley-Blackwell, 2017)
      Trust is indispensable not only for interpersonal relationships and social life, but for good quality healthcare. As manifested in the increasing violence and tension in patient-physician relationships, China has been ...