Browsing HMS Scholarly Articles by Title
Now showing items 3684-3703 of 17918
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Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule
(National Academy of Sciences, 2001)The structural basis of the interaction between the CD4 coreceptor and a class II major histocompatibility complex (MHC) is described. The crystal structure of a complex containing the human CD4 N-terminal two-domain ... -
Crystal Structure of the N-terminal Domain of the Group B Streptococcus Alpha C Protein
(American Society for Biochemistry and Molecular Biology, 2005)Group B Streptococcus (GBS) is the leading cause of bacterial pneumonia, sepsis, and meningitis among neonates and an important cause of morbidity among pregnant women and immunocompromised adults. Invasive diseases due ... -
Crystal structures and dynamical properties of dense CO2
(National Academy of Sciences, 2016)Structural polymorphism in dense carbon dioxide (CO2) has attracted significant attention in high-pressure physics and chemistry for the past two decades. Here, we have performed high-pressure experiments and first-principles ... -
Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis
(National Academy of Sciences, 2004)The carcinogen 2-acetylaminofluorene forms two major DNA adducts: N-(2'-deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-AAF) and its deacetylated derivative, N-(2'-deoxyguanosin-8-yl)-2-aminofluorene (dG-AF). Although the ... -
Crystal Structures of Bovine CD1d Reveal Altered αGalCer Presentation and a Restricted A’ Pocket Unable to Bind Long-Chain Glycolipids
(Public Library of Science, 2012)NKT cells play important roles in immune surveillance. They rapidly respond to pathogens by detecting microbial glycolipids when presented by the non-classical MHC I homolog CD1d. Previously, ruminants were considered to ... -
Crystalline Cataract Caused by a Heterozygous Missense Mutation in γD-Crystallin (CRYGD)
(Molecular Vision, 2011)Purpose: To describe phenotypic characteristics of two pedigrees manifesting early onset crystalline cataract with mutations in the γD-crystallin gene (CRYGD). Methods: A detailed medical history was obtained from two ... -
Crystalline silica-induced leukotrieneB4-dependent inflammation promotes lung tumor growth
(2015)Chronic exposure to crystalline silica (CS) causes silicosis, an irreversible lung inflammatory disease that may eventually lead to lung cancer. In this study, we demonstrate that in K-rasLA1 mice, CS exposure markedly ... -
Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia
(The Rockefeller University Press, 2014)Despite extensive insights into the underlying genetics and biology of acute myeloid leukemia (AML), overall survival remains poor and new therapies are needed. We found that casein kinase 1 α (Csnk1a1), a serine-threonine ... -
CT Coronary Angiography: 256-Slice and 320-Detector Row Scanners
(Springer Nature, 2010)Multidetector computed tomography (MDCT) has rapidly evolved from 4-detector row systems in 1998 to 256-slice and 320-detector row CT systems. With smaller detector element size and faster gantry rotation speed, spatial ... -
CT-based radiomic signature predicts distant metastasis in lung adenocarcinoma
(Elsevier BV, 2015)Background and Purpose: Radiomics provides opportunities to quantify the tumor phenotype non-invasively by applying a large number of quantitative imaging features. This study evaluates computed-tomography (CT) radiomic ... -
CTCF Orchestrates Long-Range Cohesin-Driven V(D)J Recombinational Scanning
(Springer Nature Publishing Group, 2020-07-27)RAG endonuclease initiates V(D)J recombination in progenitor (pro)-B cells1. Upon binding a recombination center (RC)-based JH, RAG scans upstream chromatin via loop extrusion, potentially mediated by cohesin, to locate ... -
CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies
(Wiley-Blackwell, 2014)The neurofibromatoses (NF) are autosomal dominant genetic disorders that encompass the rare diseases NF1, NF2, and schwannomatosis. The NFs affect more people worldwide than Duchenne muscular dystrophy and Huntington's ... -
CTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Control
(Public Library of Science, 2012)Cytotoxic T lymphocyte (CTL) responses targeting specific HIV proteins, in particular Gag, have been associated with relative control of viral replication \(in\) \(vivo\). However, Gag-specific CTL can also be detected in ... -
CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition
(Lippincott Williams & Wilkins, 2016)The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) immune checkpoints are negative regulators of T-cell immune function. Inhibition of these targets, resulting in increased activation ... -
Cultural competency of health-care providers in a Swiss University Hospital: self-assessed cross-cultural skillfulness in a cross-sectional study
(BioMed Central, 2014)Background: As the diversity of the European population evolves, measuring providers’ skillfulness in cross-cultural care and understanding what contextual factors may influence this is increasingly necessary. Given limited ... -
Cultural context and impact of alcohol use in the Sundarban Delta, West Bengal, India
(Elsevier BV, 2006)Hazardous alcohol consumption is a worldwide problem with many locally distinctive features across cultures, but studies to guide policy in developing countries are notably lacking. This community study aimed to clarify ... -
Cultural dimensions of psychiatric diagnosis. A comparison of DSM-III-R and illness explanatory models in south India
(Royal College of Psychiatrists, 1995)BACKGROUND Cross-cultural research to examine the cultural validity of diagnostic categories and underlying concepts requires methods that integrate epidemiological and anthropological frameworks. METHOD The Explanatory ... -
Cultural elements underlying the community health representative – client relationship on Navajo Nation
(BioMed Central, 2017)Background: Navajo Nation Community Health Representatives (CHR) are trained community health workers (CHWs) who provide crucial services for patients and families. The success of the CHRs’ interventions depends on the ... -
Cultural epidemiology of neurasthenia spectrum disorders in four general hospital outpatient clinics of urban Pune, India
(SAGE Publications, 2011-07)Disorders emphasizing symptoms of fatigue and/or weakness, collectively termed Neurasthenia Spectrum Disorders (NSDs), typically emphasize a biological basis in the West and social origins in East Asia. In India, explanatory ... -
Cultural Epidemiology of Pandemic Influenza in Urban and Rural Pune, India: A Cross-Sectional, Mixed-Methods Study
(BMJ, 2014-12)Objective To identify and compare sociocultural features of pandemic influenza with reference to illness-related experience, meaning and behaviour in urban and rural areas of India. Design Cross-sectional, mixed-methods, ...