Browsing HMS Scholarly Articles by Title

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    • Current update on retinopathy of prematurity: screening and treatment 

      Chen, Jing; Stahl, Andreas; Hellstrom, Ann; Smith, Lois Elaine Hodgson (Ovid Technologies (Wolters Kluwer Health), 2011)
      PURPOSE OF REVIEW: Despite current treatments, retinopathy of prematurity (ROP) remains a major cause of blindness in premature infants and the incidence is increasing with increased survival of infants born at very early ...

    • Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2 

      Medina, Igor; Friedel, Perrine; Rivera, Claudio; Kahle, Kristopher T.; Kourdougli, Nazim; Uvarov, Pavel; Pellegrino, Christophe (Frontiers Media S.A., 2014)
      In the mammalian central nervous system (CNS), the inhibitory strength of chloride (Cl−)-permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular Cl− concentration ([Cl−]i). Lowering [Cl−]i ...

    • Customized Care 2020: How Medical Sequencing and Network Biology Will Enable Personalized Medicine 

      Boguski, Mark S.; Arnaout, Ramy; Hill, Colin (Biology Reports Ltd, 2009)
      Applications of next-generation nucleic acid sequencing technologies will lead to the development of precision diagnostics that will, in turn, be a major technology enabler of precision medicine. Terabyte-scale, multidimensional ...

    • Customized Prediction of Short Length of Stay Following Elective Cardiac Surgery in Elderly Patients Using a Genetic Algorithm 

      Lee, Joon; Govindan, Sapna; Celi, Leo A.; Khabbaz, Kamal R.; Subramaniam, Balachundhar (2013)
      Objective: To develop a customized short LOS (<6 days) prediction model for geriatric patients receiving cardiac surgery, using local data and a computational feature selection algorithm. Design: Utilization of a machine ...

    • Cutpoints for Low Appendicular Lean Mass That Identify Older Adults With Clinically Significant Weakness 

      Cawthon, Peggy M.; Peters, Katherine W.; Shardell, Michelle D.; McLean, Robert R.; Dam, Thuy-Tien L.; Kenny, Anne M.; Fragala, Maren S.; Harris, Tamara B.; Kiel, Douglas P.; Guralnik, Jack M.; Ferrucci, Luigi; Kritchevsky, Stephen B.; Vassileva, Maria T.; Studenski, Stephanie A.; Alley, Dawn E. (Oxford University Press, 2014)
      Background. Low lean mass is potentially clinically important in older persons, but criteria have not been empirically validated. As part of the FNIH (Foundation for the National Institutes of Health) Sarcopenia Project, ...

    • Cuz1/Ynl155w, a Zinc-dependent Ubiquitin-binding Protein, Protects Cells from Metalloid-induced Proteotoxicity 

      Hanna, John; Waterman, David; Isasa, Marta; Elsasser, Suzanne; Shi, Yuan; Gygi, Steven; Finley, Daniel (American Society for Biochemistry and Molecular Biology, 2014)
      Background: Protein misfolding, a universal threat to cells, is dealt with by the ubiquitin-proteasome system. Results: Ynl155w is a zinc-dependent ubiquitin-binding protein, interacts with proteasome and Cdc48, and is ...

    • CXCR3 Controls T-Cell Accumulation in Fat Inflammation 

      Rocha, V. Z.; Folco, Eduardo; Ozdemir, Cafer; Sheikine, Y.; Christen, T.; Sukhova, Galina K.; Tang, E. H. C.; Bittencourt, M. S.; Santos, R. D.; Luster, Andrew David; Cohen, David E; Libby, Peter (Ovid Technologies (Wolters Kluwer Health), 2014)
      Objective—Obesity associates with increased numbers of inflammatory cells in adipose tissue (AT), including T cells, but the mechanism of T-cell recruitment remains unknown. This study tested the hypothesis that the chemokine ...

    • A Cyberday in the Life 

      Bates, David (American Medical Association (AMA), 1996-03-13)
      At 9 PM Sunday, February 5,2006, Dr Susan Scott returned home from a weekend of cross-country skiing, tucked her chil¬ dren in bed, sank down on the couch in front of her large-screen three-dimensional information center ...

    • Cyclic AMP Responsive Element Binding Proteins Are Involved in ‘Emergency’ Granulopoiesis through the Upregulation of CCAAT/Enhancer Binding Protein β 

      Hirai, Hideyo; Kamio, Naoka; Huang, Gang; Matsusue, Akiko; Ogino, Shinpei; Kimura, Nobuhiko; Satake, Sakiko; Ashihara, Eishi; Imanishi, Jiro; Tenen, Daniel Geoffrey; Maekawa, Taira (Public Library of Science, 2013)
      In contrast to the definitive role of the transcription factor, CCAAT/Enhancer binding protein α (C/EBPα), in steady-state granulopoiesis, previous findings have suggested that granulopoiesis during emergency situations, ...

    • A Cyclic-di-GMP Receptor Required for Bacterial Exopolysaccharide Production 

      Lee, Vincent T.; Matewish, Jody M; Kessler, Jennifer L; Hyodo, Mamoru; Hayakawa, Yoshihiro; Lory, Stephen (Blackwell Publishing Ltd, 2007)
      Bis-(3′,5′)-cyclic-dimeric-guanosine monophosphate (c-di-GMP) has been shown to be a global regulatory molecule that modulates the reciprocal responses of bacteria to activate either virulence pathways or biofilm formation. ...

    • Cyclin A2 promotes DNA repair in the brain during both development and aging 

      Gygli, Patrick E.; Chang, Joshua C.; Gokozan, Hamza N.; Catacutan, Fay P.; Schmidt, Theresa A.; Kaya, Behiye; Goksel, Mustafa; Baig, Faisal S.; Chen, Shannon; Griveau, Amelie; Michowski, Wojciech; Wong, Michael; Palanichamy, Kamalakannan; Sicinski, Piotr; Nelson, Randy J.; Czeisler, Catherine; Otero, José J. (Impact Journals LLC, 2016)
      Various stem cell niches of the brain have differential requirements for Cyclin A2. Cyclin A2 loss results in marked cerebellar dysmorphia, whereas forebrain growth is retarded during early embryonic development yet achieves ...

    • Cyclin D activates the Rb tumor suppressor by mono-phosphorylation 

      Narasimha, Anil M; Kaulich, Manuel; Shapiro, Gary S; Choi, Yoon J; Sicinski, Piotr; Dowdy, Steven F (eLife Sciences Publications, Ltd, 2014)
      The widely accepted model of G1 cell cycle progression proposes that cyclin D:Cdk4/6 inactivates the Rb tumor suppressor during early G1 phase by progressive multi-phosphorylation, termed hypo-phosphorylation, to release ...

    • Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells 

      Das, Gaurav; Choi, Yoon; Sicinski, Piotr; Levine, Edward M (BioMed Central, 2009)
      Background: Maintaining the correct balance of proliferation versus differentiation in retinal progenitor cells (RPCs) is essential for proper development of the retina. The cell cycle regulator cyclin D1 is expressed in ...

    • Cyclin D1 Provides a Link Between Development and Oncogenesis in the Retina and Breast 

      Sicinski, Piotr; Donaher, Joana Liu; Parker, Susan B.; Li, Tiansen; Fazeli, Amin; Gardner, Humphrey; Haslam, Sandra Z.; Bronson, Roderick T.; Elledge, Stephen; Weinberg, Robert A. (Elsevier BV, 1995-08)

    • Cyclin D1 Represses Gluconeogenesis via Inhibition of the Transcriptional Coactivator PGC1α 

      Bhalla, Kavita; Liu, Wan-Ju; Thompson, Keyata; Anders, Lars; Devarakonda, Srikripa; Dewi, Ruby; Buckley, Stephanie; Hwang, Bor-Jang; Polster, Brian; Dorsey, Susan G.; Sun, Yezhou; Sicinski, Piotr; Girnun, Geoffrey D. (American Diabetes Association, 2014)
      Hepatic gluconeogenesis is crucial to maintain normal blood glucose during periods of nutrient deprivation. Gluconeogenesis is controlled at multiple levels by a variety of signal transduction and transcriptional pathways. ...

    • Cyclin D1-CDK4 Controls Glucose Metabolism Independently of Cell Cycle Progression 

      Lee, Yoonjin; Dominy, John E.; Choi, Yoon Jong; Jurczak, Michael; Tolliday, Nicola; Camporez, Joao Paulo; Chim, Helen; Lim, Ji-Hong; Ruan, Hai-Bin; Yang, Xiaoyong; Vazquez, Francisca; Sicinski, Piotr; Shulman, Gerald I.; Puigserver, Pere (2014)
      Insulin constitutes a major evolutionarily conserved hormonal axis for maintaining glucose homeostasis1-3; dysregulation of this axis causes diabetes2,4. PGC-1α links insulin signaling to the expression of glucose and lipid ...

    • Cyclin D2 is Essential for the Compensatory Beta-Cell Hyperplastic Response to Insulin Resistance in Rodents 

      Georgia, Senta; Hinault, Charlotte; Kawamori, Dan; Hu, Jiang; Meyer, John; Kanji, Murtaza; Bhushan, Anil; Kulkarni, Rohit Narayan (American Diabetes Association, 2010)
      OBJECTIVE: A major determinant of the progression from insulin resistance to the development of overt type 2 diabetes is a failure to mount an appropriate compensatory β-cell hyperplastic response to maintain normoglycemia. ...

    • Cyclin F Disruption Compromises Placental Development and Affects Normal Cell Cycle Execution 

      Tetzlaff, Michael T.; Bai, Chang; Finegold, Milton; Wilson, John; Harper, J. Wade; Mahon, Kathleen A.; Elledge, Stephen J. (American Society for Microbiology, 2004)
      Human cyclin F was originally isolated as a cDNA capable of suppressing the temperature sensitivity of a Saccharomyces cerevisiae cdc4-1 mutant. Its tightly regulated expression and high conservation in the evolutionary ...

    • Cyclin-dependent kinase 11p110 (CDK11p110) is crucial for human breast cancer cell proliferation and growth 

      Zhou, Yubing; Han, Chao; Li, Duolu; Yu, Zujiang; Li, Fengmei; Li, Feng; An, Qi; Bai, Huili; Zhang, Xiaojian; Duan, Zhenfeng; Kan, Quancheng (Nature Publishing Group, 2015)
      Cyclin-dependent kinases (CDKs) play important roles in the development of many types of cancers by binding with their paired cyclins. However, the function of CDK11 larger protein isomer, CDK11p110, in the tumorigenesis ...

    • Cyclin-Dependent Kinase 4/6 Inhibition in Cancer Therapy 

      Johnson, Neil; Shapiro, Geoffrey Ira (Landes Bioscience, 2012)