Browsing HMS Scholarly Articles by Title

Now showing items 3759-3778 of 17920

    • Cystathionine β-Synthase Inhibition Is a Potential Therapeutic Approach to Treatment of Ischemic Injury 

      Chan, Su Jing; Chai, Chou; Lim, Tze Wei; Yamamoto, Mie; Lo, Eng H; Lai, Mitchell Kim Peng; Wong, Peter Tsun Hon (SAGE Publications, 2015)
      Hydrogen sulfide (H2S) has been reported to exacerbate stroke outcome in experimental models. Cystathionine β-synthase (CBS) has been implicated as the predominant H2S-producing enzyme in central nervous system. When SH-SY5Y ...

    • Cystatin C deficiency in human atherosclerosis and aortic aneurysms 

      Shi, Guo-Ping; Sukhova, Galina K.; Grubb, Anders; Ducharme, Anique; Rhode, Luis H.; Lee, Richard Theodore; Ridker, Paul M.; Libby, Peter; Chapman, Harold A. (American Society for Clinical Investigation, 1999)
      The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves breakdown of the elastic laminae. Elastolytic cysteine proteases, including cathepsins S and K, are overexpressed at sites of arterial elastin ...

    • Cystatin C Deficiency Promotes Epidermal Dysplasia in K14-HPV16 Transgenic Mice 

      Yu, Weifang; Liu, Jian; Shi, Michael A.; Wang, Jianan; Xiang, Meixiang; Kitamoto, Shiro; Wang, Bing; Sukhova, Galina K.; Murphy, George F.; Orasanu, Gabriela; Grubb, Anders; Shi, Guo-Ping; Câmara, Niels Olsen Saraiva (Public Library of Science, 2010)
      Background: Cysteine protease cathepsins are important in extracellular matrix protein degradation, cell apoptosis, and angiogenesis. Mice lacking cathepsins are protected from tumor progression in several animal models, ...

    • Cystatin C is Downregulated in Prostate Cancer and Modulates Invasion of Prostate Cancer Cells via MAPK/Erk and Androgen Receptor Pathways 

      Wegiel, Barbara; Jiborn, Thomas; Abrahamson, Magnus; Helczynski, Leszek; Otterbein, Leo E.; Persson, Jenny Liao; Bjartell, Anders (Public Library of Science, 2009)
      Cystatin C is believed to prevent tumor progression by inhibiting the activities of a family of lysosomal cysteine proteases. However, little is known about the precise mechanism of cystatin C function in prostate cancer. ...

    • Cystatin C-Based Renal Function Changes After Antiretroviral Initiation: A Substudy of a Randomized Trial 

      Gupta, Samir K.; Kitch, Douglas; Tierney, Camlin; Daar, Eric S.; Sax, Paul E.; Melbourne, Kathleen; Ha, Belinda; McComsey, Grace A. (Oxford University Press, 2014)
      Background. The effects of antiretrovirals on cystatin C-based renal function estimates are unknown. Methods. We analyzed changes in renal function using creatinine and cystatin C-based estimating equations in 269 patients ...

    • Cysteinyl Leukotriene Antagonism Inhibits Bronchoconstriction in Respose to Hypertonic Saline Inhalation in Asthma 

      Kazani, S; Sadeh, J; Bunga, S; Wechsler, ME; Israel, Elliot
      Background: In asthma, cysteinyl leukotrienes (CysLTs) play varying roles in the bronchomotor response to multiple provocative stimuli. The contribution of CysLTs on the airway's response to hypertonic saline (HS) inhalation ...

    • Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts 

      Kanaoka, Yoshihide; Boyce, Joshua A. (The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease, 2014)
      Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification ...

    • Cystic Papillary Pattern in Pancreatic Ductal Adenocarcinoma 

      Kelly, Paul J.; Shinagare, Shweta; Sainani, Nisha I.; Hong, Xiao; Ferrone, Cristina Rosa; Yilmaz, Omer Hidir; Fernandez-Del Castillo, Carlos F.; Lauwers, Gregory Y.; Deshpande, Vikram (Ovid Technologies (Wolters Kluwer Health), 2012)
      INTRODUCTION: The prototypic pancreatic ductal adenocarcinoma shows small-caliber glands that are placed within an exuberant desmoplastic stromal reaction. A number of histologic patterns have been described, and the ...

    • Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection 

      Cserti-Gazdewich, Christine M; Dhabangi, Aggrey; Musoke, Charles; Ssewanyana, Isaac; Ddungu, Henry; Nakiboneka-Ssenabulya, Deborah; Nabukeera-Barungi, Nicolette; Mpimbaza, Arthur; Dzik, Walter Henry (Blackwell Publishing Ltd, 2012)
      As a leading cause of childhood mortality worldwide, selection pressure by Plasmodium falciparum continues to shape the human genome. Severe disturbances within the microcirculation result from the adhesion of infected ...

    • Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. 

      Shao, Zhuo; Fu, Zhong Jie; Stahl, A.; Joyal, Julie Anne; Hatton, Colin Paul; Juan, A.; Hurst, C.; Evans, L.; Cui, Z.; Pei, D.; Gong, Yan; Xu, D.; Tian, K.; Bogardus, H.; Edin, M. L.; Lih, F.; Sapieha, P.; Chen, Jing; Panigrahy, Dipak; Hellstrom, A.; Zeldin, D. C.; Smith, Lois Elaine Hodgson (Ovid Technologies (Wolters Kluwer Health), 2014)
      OBJECTIVE: Regulation of angiogenesis is critical for many diseases. Specifically, pathological retinal neovascularization, a major cause of blindness, is suppressed with dietary ω3-long-chain polyunsaturated fatty acids ...

    • Cytochrome P450-Derived Eicosanoids: The Neglected Pathway in Cancer 

      Panigrahy, Dipak; Kaipainen, Arja; Greene, Emily R.; Huang, Sui (Springer US, 2010)
      Endogenously produced lipid autacoids are locally acting small molecule mediators that play a central role in the regulation of inflammation and tissue homeostasis. A well-studied group of autacoids are the products of ...

    • Cytokine and Antioxidant Regulation in the Intestine of the Gray Mouse Lemur (Microcebus murinus) During Torpor 

      Tessier, Shannon N.; Katzenback, Barbara A.; Pifferi, Fabien; Perret, Martine; Storey, Kenneth B. (Elsevier, 2015)
      During food shortages, the gray mouse lemur (Microcebus murinus) of Madagascar experiences daily torpor thereby reducing energy expenditures. The present study aimed to understand the impacts of torpor on the immune system ...

    • Cytokine-induced killer cells efficiently kill stem-like cancer cells of nasopharyngeal carcinoma via the NKG2D-ligands recognition 

      Wei, Fang; Rong, Xiao-Xiang; Xie, Rao-Ying; Jia, Li-Ting; Wang, Hui-Yan; Qin, Yu-Juan; Chen, Lin; Shen, Hong-Fen; Lin, Xiao-Lin; Yang, Jie; Yang, Sheng; Hao, Wei-Chao; Chen, Yan; Xiao, Sheng-Jun; Zhou, Hui-Rong; Lin, Tao-Yan; Chen, Yu-Shuang; Sun, Yan; Yao, Kai-Tai; Xiao, Dong (Impact Journals LLC, 2015)
      Cancer stem cells (CSCs) are considered to be the root cause for cancer treatment failure. Thus, there remains an urgent need for more potent and safer therapies against CSCs for curing cancer. In this study, the antitumor ...

    • Cytokines and Growth Factors Positively and Negatively Regulate Interstitial Collagen Gene Expression in Human Vascular Smooth Muscle Cells 

      Amento, Edward P.; Ehsani, Niloofar; Palmer, Helen; Libby, Peter (American Heart Association, 1991)
      Human atheromas accumulate extracellular matrix proteins such as collagen types I and III. We tested whether cytokines or growth factors produced by cells found in human atherosclerotic plaques alter collagen gene expression ...

    • Cytokines in Systemic Lupus Erythematosus 

      Poole, Brian D.; Niewold, Timothy B.; Tsokos, George C.; Via, Charles S. (Hindawi Publishing Corporation, 2010)

    • Cytokines in Systemic Lupus Erythematosus 2011 

      Poole, Brian D.; Niewold, Timothy B.; Tsokos, George C. (Hindawi Publishing Corporation, 2012)

    • Cytological profiling: providing more haystacks for chemists' needles 

      Lorang, Janet; King, Randall Wharton (BioMed Central, 2005)
      Conventional high-throughput ‘chemical genetic’ screening seeks to identify small-molecule inhibitors of a specific protein or pathway. A recent study describes how unbiased screening of cellular morphology, followed by ...

    • Cytomegalovirus Infection Causes an Increase of Arterial Blood Pressure 

      Cheng, Jilin; Ke, Qingen; Jin, Zhuang; Wang, Haibin; Kocher, Olivier Nicolas; Morgan, James P.; Zhang, Jielin; Crumpacker, Clyde S. (Public Library of Science, 2009)
      Cytomegalovirus (CMV) infection is a common infection in adults (seropositive 60–99% globally), and is associated with cardiovascular diseases, in line with risk factors such as hypertension and atherosclerosis. Several ...

    • Cytomegalovirus Reinfections Stimulate CD8 T-Memory Inflation 

      Trgovcich, Joanne; Kincaid, Michelle; Thomas, Alicia; Griessl, Marion; Zimmerman, Peter; Dwivedi, Varun; Bergdall, Valerie; Klenerman, Paul; Cook, Charles H. (Public Library of Science, 2016)
      Cytomegalovirus (CMV) has been shown to induce large populations of CD8 T-effector memory cells that unlike central memory persist in large quantities following infection, a phenomenon commonly termed “memory inflation”. ...

    • Cytomegalovirus-Specific T Cells Persist at Very High Levels during Long-Term Antiretroviral Treatment of HIV Disease 

      Naeger, David M.; Martin, Jeffrey Michael; Sinclair, Elizabeth; Hunt, Peter K.; Bangsberg, David Roy; Hecht, Frederick; Hsue, Priscilla; McCune, Joseph M.; Deeks, Steven G. (Public Library of Science, 2010)
      Background: In healthy, HIV seronegative, CMV seropositive adults, a large proportion of T cells are CMV-specific. High-level CMV-specific T cell responses are associated with accelerated immunologic aging (‘‘immunosenesence’’) ...