Browsing HMS Scholarly Articles by Title
Now showing items 3765-3784 of 17922
-
Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts
(The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease, 2014)Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification ... -
Cystic Papillary Pattern in Pancreatic Ductal Adenocarcinoma
(Ovid Technologies (Wolters Kluwer Health), 2012)INTRODUCTION: The prototypic pancreatic ductal adenocarcinoma shows small-caliber glands that are placed within an exuberant desmoplastic stromal reaction. A number of histologic patterns have been described, and the ... -
Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection
(Blackwell Publishing Ltd, 2012)As a leading cause of childhood mortality worldwide, selection pressure by Plasmodium falciparum continues to shape the human genome. Severe disturbances within the microcirculation result from the adhesion of infected ... -
Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report.
(Ovid Technologies (Wolters Kluwer Health), 2014)OBJECTIVE: Regulation of angiogenesis is critical for many diseases. Specifically, pathological retinal neovascularization, a major cause of blindness, is suppressed with dietary ω3-long-chain polyunsaturated fatty acids ... -
Cytochrome P450-Derived Eicosanoids: The Neglected Pathway in Cancer
(Springer US, 2010)Endogenously produced lipid autacoids are locally acting small molecule mediators that play a central role in the regulation of inflammation and tissue homeostasis. A well-studied group of autacoids are the products of ... -
Cytokine and Antioxidant Regulation in the Intestine of the Gray Mouse Lemur (Microcebus murinus) During Torpor
(Elsevier, 2015)During food shortages, the gray mouse lemur (Microcebus murinus) of Madagascar experiences daily torpor thereby reducing energy expenditures. The present study aimed to understand the impacts of torpor on the immune system ... -
Cytokine-induced killer cells efficiently kill stem-like cancer cells of nasopharyngeal carcinoma via the NKG2D-ligands recognition
(Impact Journals LLC, 2015)Cancer stem cells (CSCs) are considered to be the root cause for cancer treatment failure. Thus, there remains an urgent need for more potent and safer therapies against CSCs for curing cancer. In this study, the antitumor ... -
Cytokines and Growth Factors Positively and Negatively Regulate Interstitial Collagen Gene Expression in Human Vascular Smooth Muscle Cells
(American Heart Association, 1991)Human atheromas accumulate extracellular matrix proteins such as collagen types I and III. We tested whether cytokines or growth factors produced by cells found in human atherosclerotic plaques alter collagen gene expression ... -
Cytokines in Systemic Lupus Erythematosus
(Hindawi Publishing Corporation, 2010) -
Cytokines in Systemic Lupus Erythematosus 2011
(Hindawi Publishing Corporation, 2012) -
Cytological profiling: providing more haystacks for chemists' needles
(BioMed Central, 2005)Conventional high-throughput ‘chemical genetic’ screening seeks to identify small-molecule inhibitors of a specific protein or pathway. A recent study describes how unbiased screening of cellular morphology, followed by ... -
Cytomegalovirus Infection Causes an Increase of Arterial Blood Pressure
(Public Library of Science, 2009)Cytomegalovirus (CMV) infection is a common infection in adults (seropositive 60–99% globally), and is associated with cardiovascular diseases, in line with risk factors such as hypertension and atherosclerosis. Several ... -
Cytomegalovirus Reinfections Stimulate CD8 T-Memory Inflation
(Public Library of Science, 2016)Cytomegalovirus (CMV) has been shown to induce large populations of CD8 T-effector memory cells that unlike central memory persist in large quantities following infection, a phenomenon commonly termed “memory inflation”. ... -
Cytomegalovirus-Specific T Cells Persist at Very High Levels during Long-Term Antiretroviral Treatment of HIV Disease
(Public Library of Science, 2010)Background: In healthy, HIV seronegative, CMV seropositive adults, a large proportion of T cells are CMV-specific. High-level CMV-specific T cell responses are associated with accelerated immunologic aging (‘‘immunosenesence’’) ... -
Cytoplasmic CUG RNA Foci Are Insufficient to Elicit Key DM1 Features
(Public Library of Science, 2008)The genetic basis of myotonic dystrophy type I (DM1) is the expansion of a CTG tract located in the 3′ untranslated region of DMPK. Expression of mutant RNAs encoding expanded CUG repeats plays a central role in the ... -
The Cytoplasmic Tail of FPC Antagonizes the Full-Length Protein in the Regulation of mTOR Pathway
(Public Library of Science, 2014)FPC (fibrocystin or polyductin) is a single transmembrane receptor-like protein, responsible for the human autosomal recessive polycystic kidney disease (ARPKD). It was recently proposed that FPC undergoes a Notch-like ... -
Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses
(Springer Science and Business Media LLC, 2020-01-14)Base editors are widely used engineered proteins that introduce targeted point mutations into DNA without creating double-stranded DNA breaks. The application of base editors to study and treat genetic diseases is dependent ... -
A Cytosine Methytransferase Modulates the Cell Envelope Stress Response in the Cholera Pathogen
(Public Library of Science, 2015)DNA methylation is a key epigenetic regulator in all domains of life, yet the effects of most bacterial DNA methyltransferases on cellular processes are largely undefined. Here, we used diverse techniques, including bisulfite ... -
Cytosine specific DNA sequencing with hydrogen peroxide
(Oxford University Press (OUP), 1995) -
Cytoskeletal Mechanics of Proplatelet Maturation and Platelet Release
(Rockefeller University Press, 2010)Megakaryocytes generate platelets by remodeling their cytoplasm into long proplatelet extensions, which serve as assembly lines for platelet production. Although the mechanics of proplatelet elongation have been studied, ...