Browsing HMS Scholarly Articles by Title
Now showing items 4143-4162 of 17922
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Development of Metabolic Indicators of Burn Injury: Very Low Density Lipoprotein (VLDL) and Acetoacetate Are Highly Correlated to Severity of Burn Injury in Rats
(MDPI, 2012)Hypermetabolism is a significant sequela to severe trauma such as burns, as well as critical illnesses such as cancer. It persists in parallel to, or beyond, the original pathology for many months as an often-fatal ... -
Development of Multinuclear Polymeric Nanoparticles as Robust Protein Nanocarriers
(Wiley-Blackwell, 2014)One limitation of current biodegradable polymeric nanoparticles is their inability to effectively encapsulate and sustainably release proteins while maintaining protein bioactivity. Here we report the engineering of a ... -
Development of paroxysmal nocturnal hemoglobinuria in CALR-positive myeloproliferative neoplasm
(Dove Medical Press, 2016)Paroxysmal nocturnal hemoglobinuria (PNH), a disease characterized by intravascular hemolysis, thrombosis, and bone marrow failure, is associated with mutations in the PIG-A gene, resulting in a deficiency of glycosylpho ... -
Development of phenotype algorithms using electronic medical records and incorporating natural language processing
(BMJ Publishing Group Ltd., 2015)Electronic medical records are emerging as a major source of data for clinical and translational research studies, although phenotypes of interest need to be accurately defined first. This article provides an overview of ... -
Development of Preterm and Full-Term Infant Ability on AB, Recall Memory, Transparent Barrier Detour, and Means-End Tasks
(Society for Research in Child Development, 1996)10 preterm and 10 full-term infants were tested longitudinally from 28 to 60 weeks of age on a modified version of the AB task, a nonreaching AB task, a Barrier Detour task, a Means-End task, and Perseveration in the ... -
Development of proteasome inhibitors as research tools and cancer drugs
(The Rockefeller University Press, 2012)The proteasome is the primary site for protein degradation in mammalian cells, and proteasome inhibitors have been invaluable tools in clarifying its cellular functions. The anticancer agent bortezomib inhibits the major ... -
Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice
(Ivyspring International Publisher, 2016)Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome associated with ribosomal protein (RP) gene mutations. Recent studies have also demonstrated an increased risk of cancer predisposition among DBA ... -
Development of Specific Aspects of Spirituality during a 6-Month Intensive Yoga Practice
(Hindawi Publishing Corporation, 2012)The majority of research on yoga focuses on its psychophysiological and therapeutic benefits, while the spiritual aspects are rarely addressed. Changes of specific aspects of spirituality were thus investigated among 160 ... -
Development of Stereotactic Mass Spectrometry for Brain Tumor Surgery
(Oxford University Press (OUP), 2011)BACKGROUND: Surgery remains the first and most important treatment modality for the majority of solid tumors. Across a range of brain tumor types and grades, postoperative residual tumor has a great impact on prognosis. ... -
Development of the SAFE Checklist Tool for Assessing Site-Level Threats to Child Protection: Use of Delphi Methods and Application to Two Sites in India
(Public Library of Science, 2015)Background: The child protection community is increasingly focused on developing tools to assess threats to child protection and the basic security needs and rights of children and families living in adverse circumstances. ... -
Development of the Serious Illness Care Program: a randomised controlled trial of a palliative care communication intervention
(BMJ Publishing Group, 2015)Introduction: Ensuring that patients receive care that is consistent with their goals and values is a critical component of high-quality care. This article describes the protocol for a cluster randomised controlled trial ... -
Development, Calibration and Performance of an HIV Transmission Model Incorporating Natural History and Behavioral Patterns: Application in South Africa
(Public Library of Science, 2014)Understanding HIV transmission dynamics is critical to estimating the potential population-wide impact of HIV prevention and treatment interventions. We developed an individual-based simulation model of the heterosexual ... -
Development, roll-out and impact of Xpert MTB/RIF for tuberculosis: what lessons have we learnt and how can we do better?
(European Respiratory Society, 2016)The global roll-out of Xpert MTB/RIF (Cepheid Inc., Sunnyvale, CA, USA) has changed the diagnostic landscape of tuberculosis (TB). More than 16 million tests have been performed in 122 countries since 2011, and detection ... -
Developmental and Molecular Characterization of Mutations in the Drosophila-Raf Serine/Threonine Protein Kinase
(The Company of Biologists, 1993-05-01)Formation of the tail region of the Drosophila larva requires the activities of the terminal class genes. Genetic and molecular analyses of these genes suggests that localized activation of the receptor tyrosine kinase ... -
The developmental basis of adult arrhythmia: atrial fibrillation as a paradigm
(Frontiers Media S.A., 2013)Normal cardiac rhythm is one of the most fundamental physiologic phenomena, emerging early in the establishment of the vertebrate body plan. The developmental pathways underlying the patterning and maintenance of stable ... -
Developmental biology: Our fly cousins' gut
(Nature Research (part of Springer Nature), 2008) -
Developmental Controls are Re-Expressed during Induction of Neurogenesis in the Neocortex of Young Adult Mice
(Frontiers Research Foundation, 2012)Whether induction of low-level neurogenesis in normally non-neurogenic regions of the adult brain mimics aspects of developmental neurogenesis is currently unknown. Previously, we and others identified that biophysically ... -
Developmental correlates and predictors of emotional availability in mother–child interaction: A longitudinal study from infancy to middle childhood
(Cambridge University Press (CUP), 2012)In this investigation we examined the developmental correlates and predictors of maternal emotional availability in interactions with their 7-year-old children among a sample of families at psychosocial risk. We found ... -
Developmental Decrease of Neuronal Chloride Concentration Is Independent of Trauma in Thalamocortical Brain Slices
(Public Library of Science, 2016)The intraneuronal chloride concentration ([Cl-]i) is paramount for determining the polarity of signaling at GABAA synapses in the central nervous system. Sectioning hippocampal brain slices increases [Cl-]i in the superficial ... -
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
(National Academy of Sciences, 2003)SIRT1 is a mammalian homolog of the Saccharomyces cerevisiae chromatin silencing factor Sir2. Dominant-negative and overexpression studies have implicated a role for SIRT1 in deacetylating the p53 tumor suppressor protein ...