Browsing HMS Scholarly Articles by Title
Now showing items 4173-4192 of 17922
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Dextran-Coated Iron Oxide Nanoparticles: a Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics and Therapy
(American Chemical Society, 2011)Advances in our understanding of the genetic basis of disease susceptibility coupled with prominent successes for molecular targeted therapies have resulted in an emerging strategy of personalized medicine. This approach ... -
Dextroamphetamine (but Not Atomoxetine) Induces Reanimation from General Anesthesia: Implications for the Roles of Dopamine and Norepinephrine in Active Emergence
(Public Library of Science, 2015)Methylphenidate induces reanimation (active emergence) from general anesthesia in rodents, and recent evidence suggests that dopaminergic neurotransmission is important in producing this effect. Dextroamphetamine causes ... -
The Deyo-Charlson and Elixhauser-van Walraven Comorbidity Indices as predictors of mortality in critically ill patients
(BMJ Publishing Group, 2015)Objectives: Our primary objective was to compare the utility of the Deyo-Charlson Comorbidity Index (DCCI) and Elixhauser-van Walraven Comorbidity Index (EVCI) to predict mortality in intensive care unit (ICU) patients. ... -
DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors
(American Chemical Society, 2014)Drug-resistance acquisition through kinase gate-keeper mutations is a major hurdle in the clinic. Here, we determined the first crystal structures of the human FGFR4 kinase domain (FGFR4K) alone and complexed with ponatinib, ... -
Di(2-ethylhexyl) Phthalate Metabolites May Alter Thyroid Hormone Levels in Men
(National Institute of Environmental Health Sciences, 2007)Background: Phthalates are used extensively in many personal-care and consumer products, resulting in widespread nonoccupational human exposure through multiple routes and media. A limited number of animal studies suggest ... -
Diabetes and Lipid Screening Among Patients in Primary Care: A Cohort Study
(BioMed Central, 2008)Background: Obesity is associated with increased cardiovascular diseases and diabetes mellitus. Guidelines call for intensified glucose and lipid screening among overweight and obese patients. Data on compliance with these ... -
Diabetes and mortality in patients with prostate cancer: a meta-analysis
(Springer International Publishing, 2016)Background: There are conflicting results as to the association between pre-existing diabetes and the risk of mortality in patients with prostate cancer. The purpose of this study is to estimate the influence of pre-existing ... -
Diabetes and Sepsis: Preclinical Findings and Clinical Relevance
(American Diabetes Association, 2011) -
Diabetes and the Risk of Developing Parkinson’s Disease in Denmark
(American Diabetes Association, 2011)Objective: Insulin contributes to normal brain function. Previous studies have suggested associations between midlife diabetes and neurodegenerative diseases, including Parkinson’s disease. Using Danish population registers, ... -
Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I
(Oxford University Press, 2013)Hyperglycemia and insulin resistance are key players in the development of atherosclerosis and its complications. A large body of evidence suggest that metabolic abnormalities cause overproduction of reactive oxygen species ... -
Diabetes Care for Emerging Adults: Recommendations for Transition From Pediatric to Adult Diabetes Care Systems
(American Diabetes Association, 2011) -
Diabetes Disrupts the Response of Retinal Endothelial Cells to the Angiomodulator Lysophosphatidic Acid
(American Diabetes Association, 2012)The objectives of this study were to investigate how diabetes mellitus (DM) influences responsiveness of retinal neovessels to lysophosphatidic acid (LPA) and to elucidate the underlying mechanism. To this end, we used an ... -
Diabetes Mellitus Increases the Risk of Active Tuberculosis: A Systematic Review of 13 Observational Studies
(Public Library of Science, 2008)BackgroundSeveral studies have suggested that diabetes mellitus ( DM) increases the risk of active tuberculosis (TB). The rising prevalence of DM in TB- endemic areas may adversely affect TB control. We conducted a systematic ... -
Diabetes regulates fructose absorption through thioredoxin-interacting protein
(eLife Sciences Publications, Ltd, 2016)Metabolic studies suggest that the absorptive capacity of the small intestine for fructose is limited, though the molecular mechanisms controlling this process remain unknown. Here we demonstrate that thioredoxin-interacting ... -
Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells
(Springer Science and Business Media LLC, 2019-02-13)Cell identity switches, where terminally-differentiated cells convert into different cell-types when stressed, represent a widespread regenerative strategy in animals, yet they are poorly documented in mammals. In mice, ... -
Diabetes Risk Perception and Intention to Adopt Healthy Lifestyles Among Primary Care Patients
(American Diabetes Association, 2009)OBJECTIVE—To examine perceived risk of developing diabetes in primary care patients. RESEARCH DESIGN AND METHODS—We recruited 150 nondiabetic primary care patients. We made standard clinical measurements, collected fasting ... -
Diabetes, Obesity, and Hypertension May Enhance Associations between Air Pollution and Markers of Systemic Inflammation
(National Institute of Environmental Health Sciences, 2006)Airborne particulate matter (PM) may lead to increased cardiac risk through an inflammatory pathway. Therefore, we investigated associations between ambient PM and markers of systemic inflammation among repeated measures ... -
Diabetes-Specific Nutrition Algorithm: A Transcultural Program to Optimize Diabetes and Prediabetes Care
(Current Science Inc., 2012)Type 2 diabetes (T2D) and prediabetes have a major global impact through high disease prevalence, significant downstream pathophysiologic effects, and enormous financial liabilities. To mitigate this disease burden, ... -
Diabetic Microvascular Complications: Possible Targets for Improved Macrovascular Outcomes
(Dove Medical Press, 2010)The results of recent outcome trials challenge hypotheses that tight control of both glycohemoglobin and blood pressure diminishes macrovascular events and survival among type 2 diabetic patients. Relevant questions exist ... -
Diabetic Peripheral Neuropathy as a Predictor of Asymptomatic Myocardial Ischemia in Type 2 Diabetes Mellitus: A Cross-Sectional Study
(Springer Healthcare, 2016)Introduction: Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes and has been associated with cardiovascular disease, the leading cause of mortality in diabetes. As asymptomatic ...